Immune recognition of self in immunity against cancer
Most antigens expressed by human cancer cells and recognized by host T cells and antibodies are nonmutated self antigens - molecules also expressed on the surface of normal cells. These self antigens are ineffective at triggering immune responses against cancer cells, which provides one explanation...
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| Veröffentlicht in: | The Journal of clinical investigation 2004-08, Vol.114 (4), p.468-471 |
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| container_title | The Journal of clinical investigation |
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| creator | Houghton, Alan N Guevara-Patiño, José A |
| description | Most antigens expressed by human cancer cells and recognized by host T cells and antibodies are nonmutated self antigens - molecules also expressed on the surface of normal cells. These self antigens are ineffective at triggering immune responses against cancer cells, which provides one explanation for the difficulties in trying to immunize against human cancer. A new study describes how tumors can avoid recognition by the immune system and how enhancing the affinity of the interaction between a self antigen and the MHC-I molecule may lead to cancer immunity. |
| doi_str_mv | 10.1172/JCI22685 |
| format | Article |
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| ispartof | The Journal of clinical investigation, 2004-08, Vol.114 (4), p.468-471 |
| issn | 0021-9738 1558-8238 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antibodies, Neoplasm - immunology Antigens, Neoplasm - immunology Autoantigens - immunology Bacteria - pathogenicity Biomedical research Humans Major Histocompatibility Complex - immunology Models, Immunological Neoplasms - immunology Peptides - genetics Peptides - immunology Self Tolerance T-Lymphocytes - immunology |
| title | Immune recognition of self in immunity against cancer |
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