Modified myocardial performance index for evaluation of fetal cardiac function in pre‐eclampsia
Objective To assess cardiac function by means of the modified myocardial performance index (Mod‐MPI) in fetuses of pre‐eclamptic mothers without intrauterine growth restriction and to compare this with values from normal controls. Methods A cross‐sectional study was conducted including a total of 72...
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| Veröffentlicht in: | Ultrasound in obstetrics & gynecology 2009-01, Vol.33 (1), p.51-57 |
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| creator | Api, O. Emeksiz, M. Balcin Api, M. Uǧurel, V. Unal, O. |
| description | Objective
To assess cardiac function by means of the modified myocardial performance index (Mod‐MPI) in fetuses of pre‐eclamptic mothers without intrauterine growth restriction and to compare this with values from normal controls.
Methods
A cross‐sectional study was conducted including a total of 72 fetuses at between 26 and 40 weeks' gestation. Forty fetuses of healthy mothers were assigned as the control group (Group I) while 15 fetuses of mildly pre‐eclamptic mothers constituted Group II and 17 fetuses of severely pre‐eclamptic mothers constituted Group III. Two‐dimensional gray‐scale and Doppler fetal echocardiography was used to exclude cardiac anomalies and calculate the Mod‐MPI.
Results
The mean ± SD Mod‐MPI values of Groups I, II and III were 0.43 ± 0.045, 0.44 ± 0.064 and 0.44 ± 0.064, respectively (P = 0.680). The mean aortic peak systolic velocity (PSV), the mean mitral valve early ventricular filling (E‐wave) and active atrial filling (A‐wave) peak velocities were significantly lower in fetuses of severely pre‐eclamptic mothers than in fetuses of mildly pre‐eclamptic mothers and control fetuses.
Conclusion
The fetal global myocardial function assessed by Mod‐MPI does not seem to change in mild or severe pre‐eclampsia. The lower mitral E‐wave and A‐wave peak velocities and the lower aortic PSV seem to reflect the increased cardiac afterload against which the fetal heart has to work, rather than systolic or diastolic cardiac dysfunction, in the fetuses of severely pre‐eclamptic mothers. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/uog.6272 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66788724</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66788724</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4142-6b21ce48541974fc7ce68930594bce2c5ba222cfeb2213b8ac57b2b282818623</originalsourceid><addsrcrecordid>eNqF0M1O3DAQB3CrApUtrcQTIF9AvYTaE8cfxwoBrQTiQs-R44yRqyQO9qawtz5Cn7FPgmFX7anqaTSa38xIf0KOODvjjMGnJd6fSVDwhqy4kKZiijV7ZMWMZJWSBg7Iu5y_M8akqOVbcsAN07K0K2JvYh98wJ6Om-hs6oMd6IzJxzTaySENU49PtLQUf9hhsesQJxo99bgucrvhqF8m9zoJE50T_v75C91gxzkH-57seztk_LCrh-Tu8uLu_Et1fXv19fzzdeUEF1DJDrhDoRvBjRLeKYdSm5o1RnQOwTWdBQDnsQPgdaeta1QHHWjQXEuoD8np9uyc4sOCed2OITscBjthXHIrpdJagfgvBFZr1TBd4MctdCnmnNC3cwqjTZuWs_Yl9rbE3r7EXujx7ubSjdj_hbucCzjZAZudHXwq2Yb8xwEzplaNLK7auscw4OafD9tvt1evj58Bo4uZ-g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20387508</pqid></control><display><type>article</type><title>Modified myocardial performance index for evaluation of fetal cardiac function in pre‐eclampsia</title><source>MEDLINE</source><source>Wiley Online Library Free Content</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Api, O. ; Emeksiz, M. Balcin ; Api, M. ; Uǧurel, V. ; Unal, O.</creator><creatorcontrib>Api, O. ; Emeksiz, M. Balcin ; Api, M. ; Uǧurel, V. ; Unal, O.</creatorcontrib><description>Objective
To assess cardiac function by means of the modified myocardial performance index (Mod‐MPI) in fetuses of pre‐eclamptic mothers without intrauterine growth restriction and to compare this with values from normal controls.
Methods
A cross‐sectional study was conducted including a total of 72 fetuses at between 26 and 40 weeks' gestation. Forty fetuses of healthy mothers were assigned as the control group (Group I) while 15 fetuses of mildly pre‐eclamptic mothers constituted Group II and 17 fetuses of severely pre‐eclamptic mothers constituted Group III. Two‐dimensional gray‐scale and Doppler fetal echocardiography was used to exclude cardiac anomalies and calculate the Mod‐MPI.
Results
The mean ± SD Mod‐MPI values of Groups I, II and III were 0.43 ± 0.045, 0.44 ± 0.064 and 0.44 ± 0.064, respectively (P = 0.680). The mean aortic peak systolic velocity (PSV), the mean mitral valve early ventricular filling (E‐wave) and active atrial filling (A‐wave) peak velocities were significantly lower in fetuses of severely pre‐eclamptic mothers than in fetuses of mildly pre‐eclamptic mothers and control fetuses.
Conclusion
The fetal global myocardial function assessed by Mod‐MPI does not seem to change in mild or severe pre‐eclampsia. The lower mitral E‐wave and A‐wave peak velocities and the lower aortic PSV seem to reflect the increased cardiac afterload against which the fetal heart has to work, rather than systolic or diastolic cardiac dysfunction, in the fetuses of severely pre‐eclamptic mothers. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.</description><identifier>ISSN: 0960-7692</identifier><identifier>EISSN: 1469-0705</identifier><identifier>DOI: 10.1002/uog.6272</identifier><identifier>PMID: 19086000</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cardiovascular system ; Cross-Sectional Studies ; Diseases of mother, fetus and pregnancy ; Doppler ; Female ; fetal cardiac function ; Fetal Heart - diagnostic imaging ; Fetal Heart - physiopathology ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; modified myocardial performance index ; Placental Circulation - physiology ; Pre-Eclampsia - diagnostic imaging ; Pre-Eclampsia - physiopathology ; Pregnancy ; Pregnancy. Fetus. Placenta ; pre‐eclampsia ; Ultrasonic investigative techniques ; Ultrasonography, Prenatal ; Vascular Resistance - physiology ; Young Adult</subject><ispartof>Ultrasound in obstetrics & gynecology, 2009-01, Vol.33 (1), p.51-57</ispartof><rights>Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.</rights><rights>2009 INIST-CNRS</rights><rights>Copyright (c) 2008 ISUOG.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4142-6b21ce48541974fc7ce68930594bce2c5ba222cfeb2213b8ac57b2b282818623</citedby><cites>FETCH-LOGICAL-c4142-6b21ce48541974fc7ce68930594bce2c5ba222cfeb2213b8ac57b2b282818623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fuog.6272$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fuog.6272$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,4024,27923,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20993756$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19086000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Api, O.</creatorcontrib><creatorcontrib>Emeksiz, M. Balcin</creatorcontrib><creatorcontrib>Api, M.</creatorcontrib><creatorcontrib>Uǧurel, V.</creatorcontrib><creatorcontrib>Unal, O.</creatorcontrib><title>Modified myocardial performance index for evaluation of fetal cardiac function in pre‐eclampsia</title><title>Ultrasound in obstetrics & gynecology</title><addtitle>Ultrasound Obstet Gynecol</addtitle><description>Objective
To assess cardiac function by means of the modified myocardial performance index (Mod‐MPI) in fetuses of pre‐eclamptic mothers without intrauterine growth restriction and to compare this with values from normal controls.
Methods
A cross‐sectional study was conducted including a total of 72 fetuses at between 26 and 40 weeks' gestation. Forty fetuses of healthy mothers were assigned as the control group (Group I) while 15 fetuses of mildly pre‐eclamptic mothers constituted Group II and 17 fetuses of severely pre‐eclamptic mothers constituted Group III. Two‐dimensional gray‐scale and Doppler fetal echocardiography was used to exclude cardiac anomalies and calculate the Mod‐MPI.
Results
The mean ± SD Mod‐MPI values of Groups I, II and III were 0.43 ± 0.045, 0.44 ± 0.064 and 0.44 ± 0.064, respectively (P = 0.680). The mean aortic peak systolic velocity (PSV), the mean mitral valve early ventricular filling (E‐wave) and active atrial filling (A‐wave) peak velocities were significantly lower in fetuses of severely pre‐eclamptic mothers than in fetuses of mildly pre‐eclamptic mothers and control fetuses.
Conclusion
The fetal global myocardial function assessed by Mod‐MPI does not seem to change in mild or severe pre‐eclampsia. The lower mitral E‐wave and A‐wave peak velocities and the lower aortic PSV seem to reflect the increased cardiac afterload against which the fetal heart has to work, rather than systolic or diastolic cardiac dysfunction, in the fetuses of severely pre‐eclamptic mothers. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Cross-Sectional Studies</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Doppler</subject><subject>Female</subject><subject>fetal cardiac function</subject><subject>Fetal Heart - diagnostic imaging</subject><subject>Fetal Heart - physiopathology</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>modified myocardial performance index</subject><subject>Placental Circulation - physiology</subject><subject>Pre-Eclampsia - diagnostic imaging</subject><subject>Pre-Eclampsia - physiopathology</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>pre‐eclampsia</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography, Prenatal</subject><subject>Vascular Resistance - physiology</subject><subject>Young Adult</subject><issn>0960-7692</issn><issn>1469-0705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M1O3DAQB3CrApUtrcQTIF9AvYTaE8cfxwoBrQTiQs-R44yRqyQO9qawtz5Cn7FPgmFX7anqaTSa38xIf0KOODvjjMGnJd6fSVDwhqy4kKZiijV7ZMWMZJWSBg7Iu5y_M8akqOVbcsAN07K0K2JvYh98wJ6Om-hs6oMd6IzJxzTaySENU49PtLQUf9hhsesQJxo99bgucrvhqF8m9zoJE50T_v75C91gxzkH-57seztk_LCrh-Tu8uLu_Et1fXv19fzzdeUEF1DJDrhDoRvBjRLeKYdSm5o1RnQOwTWdBQDnsQPgdaeta1QHHWjQXEuoD8np9uyc4sOCed2OITscBjthXHIrpdJagfgvBFZr1TBd4MctdCnmnNC3cwqjTZuWs_Yl9rbE3r7EXujx7ubSjdj_hbucCzjZAZudHXwq2Yb8xwEzplaNLK7auscw4OafD9tvt1evj58Bo4uZ-g</recordid><startdate>200901</startdate><enddate>200901</enddate><creator>Api, O.</creator><creator>Emeksiz, M. Balcin</creator><creator>Api, M.</creator><creator>Uǧurel, V.</creator><creator>Unal, O.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200901</creationdate><title>Modified myocardial performance index for evaluation of fetal cardiac function in pre‐eclampsia</title><author>Api, O. ; Emeksiz, M. Balcin ; Api, M. ; Uǧurel, V. ; Unal, O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4142-6b21ce48541974fc7ce68930594bce2c5ba222cfeb2213b8ac57b2b282818623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Cross-Sectional Studies</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Doppler</topic><topic>Female</topic><topic>fetal cardiac function</topic><topic>Fetal Heart - diagnostic imaging</topic><topic>Fetal Heart - physiopathology</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>modified myocardial performance index</topic><topic>Placental Circulation - physiology</topic><topic>Pre-Eclampsia - diagnostic imaging</topic><topic>Pre-Eclampsia - physiopathology</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>pre‐eclampsia</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography, Prenatal</topic><topic>Vascular Resistance - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Api, O.</creatorcontrib><creatorcontrib>Emeksiz, M. Balcin</creatorcontrib><creatorcontrib>Api, M.</creatorcontrib><creatorcontrib>Uǧurel, V.</creatorcontrib><creatorcontrib>Unal, O.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in obstetrics & gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Api, O.</au><au>Emeksiz, M. Balcin</au><au>Api, M.</au><au>Uǧurel, V.</au><au>Unal, O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modified myocardial performance index for evaluation of fetal cardiac function in pre‐eclampsia</atitle><jtitle>Ultrasound in obstetrics & gynecology</jtitle><addtitle>Ultrasound Obstet Gynecol</addtitle><date>2009-01</date><risdate>2009</risdate><volume>33</volume><issue>1</issue><spage>51</spage><epage>57</epage><pages>51-57</pages><issn>0960-7692</issn><eissn>1469-0705</eissn><abstract>Objective
To assess cardiac function by means of the modified myocardial performance index (Mod‐MPI) in fetuses of pre‐eclamptic mothers without intrauterine growth restriction and to compare this with values from normal controls.
Methods
A cross‐sectional study was conducted including a total of 72 fetuses at between 26 and 40 weeks' gestation. Forty fetuses of healthy mothers were assigned as the control group (Group I) while 15 fetuses of mildly pre‐eclamptic mothers constituted Group II and 17 fetuses of severely pre‐eclamptic mothers constituted Group III. Two‐dimensional gray‐scale and Doppler fetal echocardiography was used to exclude cardiac anomalies and calculate the Mod‐MPI.
Results
The mean ± SD Mod‐MPI values of Groups I, II and III were 0.43 ± 0.045, 0.44 ± 0.064 and 0.44 ± 0.064, respectively (P = 0.680). The mean aortic peak systolic velocity (PSV), the mean mitral valve early ventricular filling (E‐wave) and active atrial filling (A‐wave) peak velocities were significantly lower in fetuses of severely pre‐eclamptic mothers than in fetuses of mildly pre‐eclamptic mothers and control fetuses.
Conclusion
The fetal global myocardial function assessed by Mod‐MPI does not seem to change in mild or severe pre‐eclampsia. The lower mitral E‐wave and A‐wave peak velocities and the lower aortic PSV seem to reflect the increased cardiac afterload against which the fetal heart has to work, rather than systolic or diastolic cardiac dysfunction, in the fetuses of severely pre‐eclamptic mothers. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>19086000</pmid><doi>10.1002/uog.6272</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Free Content; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Biological and medical sciences Cardiovascular system Cross-Sectional Studies Diseases of mother, fetus and pregnancy Doppler Female fetal cardiac function Fetal Heart - diagnostic imaging Fetal Heart - physiopathology Gestational Age Gynecology. Andrology. Obstetrics Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences modified myocardial performance index Placental Circulation - physiology Pre-Eclampsia - diagnostic imaging Pre-Eclampsia - physiopathology Pregnancy Pregnancy. Fetus. Placenta pre‐eclampsia Ultrasonic investigative techniques Ultrasonography, Prenatal Vascular Resistance - physiology Young Adult |
| title | Modified myocardial performance index for evaluation of fetal cardiac function in pre‐eclampsia |
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