Upstream and downstream of mTOR

The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has emerged as a major effector of cell growth and proliferation via the regulation of protein synthesis. Work in the last decade clearly demonstrates that TOR controls protein synthesis through a stunning number of d...

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Veröffentlicht in:	Genes & development 2004-08, Vol.18 (16), p.1926-1945
Hauptverfasser:	Hay, Nissim, Sonenberg, Nahum
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division - physiology Energy Metabolism Growth Substances - physiology Neoplasms - physiopathology Peptide Initiation Factors - physiology Phosphorylation Protein Biosynthesis - physiology Protein Kinases - genetics Protein Kinases - physiology Ribosomal Protein S6 Kinases - physiology TOR Serine-Threonine Kinases Transcription, Genetic - physiology
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