Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389

E7389, a macrocyclic ketone analog of the marine natural product halichondrin B, currently is undergoing clinical trials for cancer. This fully synthetic agent exerts its highly potent in vitro and in vivo anticancer effects via tubulin-based antimitotic mechanisms, which are similar or identical to...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-08, Vol.64 (16), p.5760-5766
Hauptverfasser:	KUZNETSOV, Galina, TOWLE, Murray J, HONGSHENG CHENG, KAWAMURA, Takanori, TENDYKE, Karen, LIU, Diana, KISHI, Yoshito, YU, Melvin J, LITTLEFIELD, Bruce A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Caspase 3 Caspase 9 Caspases - metabolism Cell Line, Tumor Cell Membrane - drug effects Cell Membrane - physiology Cell Polarity - drug effects Cytochromes c - secretion Diploidy Enzyme Activation - drug effects Ethers, Cyclic - pharmacology Furans - pharmacology G2 Phase - drug effects Humans Ketones - pharmacology Male Medical sciences Mitochondria - drug effects Mitochondria - secretion Mitosis - drug effects Pharmacology. Drug treatments Phosphorylation - drug effects Poly(ADP-ribose) Polymerases - metabolism Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-bcl-2 - metabolism Tumors U937 Cells
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