EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy

EpCAM (epithelial cell adhesion molecule) is a cell surface molecule that is known to be highly expressed in colon and other epithelial carcinomas. EpCAM is involved in cell-to-cell adhesion and has been the target of antibody therapy in several clinical trials. To assess the value of EpCAM as a nov...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-08, Vol.64 (16), p.5818-5824
Hauptverfasser:	OSTA, Walid A, YIAN CHEN, MIKHITARIAN, Kaidi, MITAS, Michael, SALEM, Mohamed, HANNUN, Yusuf A, COLE, David J, GILLANDERS, William E
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha Catenin Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - genetics Antineoplastic agents beta Catenin Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - therapy Cadherins - biosynthesis Cadherins - genetics Cell Adhesion Molecules - antagonists & inhibitors Cell Adhesion Molecules - biosynthesis Cell Adhesion Molecules - genetics Cell Division - genetics Cell Line, Tumor Cell Movement - genetics Cytoskeletal Proteins - biosynthesis Cytoskeletal Proteins - genetics Epithelial Cell Adhesion Molecule Female Gene Expression Regulation, Neoplastic - genetics Gene Silencing Genetic Therapy - methods Humans Lymph Nodes - metabolism Lymph Nodes - pathology Lymphatic Metastasis Medical sciences Neoplasm Invasiveness Pharmacology. Drug treatments RNA, Small Interfering - genetics Trans-Activators - biosynthesis Trans-Activators - genetics Transcription, Genetic Tumors
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