A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with complicated pathogenesis that poses challenges with respect to diagnosis and monitoring of disease progression. To identify a biomarker panel that elucidates ALS disease pathogenesis, distinguishes patients with ALS...

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Veröffentlicht in:	Neurology 2009-01, Vol.72 (1), p.14-19
Hauptverfasser:	MITCHELL, R. M, FREEMAN, W. M, RANDAZZO, W. T, STEPHENS, H. E, BEARD, J. L, SIMMONS, Z, CONNOR, J. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - genetics Amyotrophic Lateral Sclerosis - blood Amyotrophic Lateral Sclerosis - cerebrospinal fluid beta 2-Microglobulin - cerebrospinal fluid Biological and medical sciences Biomarkers - blood Biomarkers - cerebrospinal fluid Cytokines - blood Cytokines - cerebrospinal fluid Enzyme-Linked Immunosorbent Assay Female Genotype Hemochromatosis Protein Histocompatibility Antigens Class I - blood Histocompatibility Antigens Class I - cerebrospinal fluid Histocompatibility Antigens Class I - genetics Humans Intercellular Signaling Peptides and Proteins - blood Intercellular Signaling Peptides and Proteins - cerebrospinal fluid Male Medical sciences Membrane Proteins - blood Membrane Proteins - cerebrospinal fluid Membrane Proteins - genetics Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nervous System Diseases - blood Nervous System Diseases - cerebrospinal fluid Neurology Polymorphism, Genetic - genetics Statistics, Nonparametric
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