Pyridone 6, a pan-Janus-activated kinase inhibitor, suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression

It has been reported that Janus tyrosine kinase (JAK)-dependent signaling pathways play a critical role in the pathogenesis of numerous malignancies and immune reactions, and inhibition of JAK has been implicated in cell growth inhibition. The role which JAK has on osteoclast differentiation and ant...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2009-01, Vol.32 (1), p.45-50
Hauptverfasser:	Kwak, Han Bok, Kim, Hun Soo, Lee, Myeung Su, Kim, Kwang-Jin, Choi, Eun-Yong, Choi, Min-Kyu, Kim, Jeong-Joong, Cho, Hae Joong, Kim, Jeong Woo, Bae, Ji-Myung, Kim, Yun-Kyung, Park, Byoung Hyun, Ha, Hyunil, Chun, Churl Hong, Oh, Jaemin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzimidazoles - pharmacology Bone Marrow Cells - drug effects Bone Resorption - drug therapy Cell Differentiation - drug effects Cell Line, Transformed Dose-Response Relationship, Drug Down-Regulation - drug effects Enzyme Inhibitors - pharmacology Macrophages - drug effects Mice NF-kappa B - metabolism NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism Osteoclasts - drug effects Osteoclasts - physiology Proto-Oncogene Proteins c-fos - metabolism Pyridones - pharmacology RANK Ligand - metabolism Signal Transduction - drug effects
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