Differential B cell expression of mouse Fc receptor homologs
Five Fc receptor homologs (FcRH1–5) possessing inhibitory and/or activating signaling motifs are differentially expressed during B cell differentiation in humans. In this analysis we describe their three mouse orthologs, moFcRH1, moFcRH2 and moFcRH3. The moFcRH genes are located in a chromosome 3 re...
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| Veröffentlicht in: | International immunology 2004-09, Vol.16 (9), p.1343-1353 |
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| creator | Davis, Randall S. Stephan, Robert P. Chen, Ching-Cheng Dennis, Glynn Cooper, Max D. |
| description | Five Fc receptor homologs (FcRH1–5) possessing inhibitory and/or activating signaling motifs are differentially expressed during B cell differentiation in humans. In this analysis we describe their three mouse orthologs, moFcRH1, moFcRH2 and moFcRH3. The moFcRH genes are located in a chromosome 3 region that is syntenic with the FcRH locus on human chromosome 1. They encode proteins with 2–5 Ig-like domains that share 20–61% extracellular identity with their human counterparts. One moFcRH1 isoform lacks a transmembrane domain as do both moFcRH2 isoforms. The other moFcRH1 isoform and two moFcRH3 isoforms have transmembrane domains and cytoplasmic ITIM and ITAM-like consensus sequences implying their inhibitory or activating signaling potential. Whereas the moFcRH1 and moFcRH3 orthologs are preferentially expressed at different stages in B cell differentiation, the structurally novel moFcRH2 gene is expressed in non-lymphoid tissues. The highly restricted pattern of moFcRH3 expression suggests this member of the phylogenetically conserved FcRH family may have an important immunoregulatory role in marginal zone B cells. |
| doi_str_mv | 10.1093/intimm/dxh137 |
| format | Article |
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In this analysis we describe their three mouse orthologs, moFcRH1, moFcRH2 and moFcRH3. The moFcRH genes are located in a chromosome 3 region that is syntenic with the FcRH locus on human chromosome 1. They encode proteins with 2–5 Ig-like domains that share 20–61% extracellular identity with their human counterparts. One moFcRH1 isoform lacks a transmembrane domain as do both moFcRH2 isoforms. The other moFcRH1 isoform and two moFcRH3 isoforms have transmembrane domains and cytoplasmic ITIM and ITAM-like consensus sequences implying their inhibitory or activating signaling potential. Whereas the moFcRH1 and moFcRH3 orthologs are preferentially expressed at different stages in B cell differentiation, the structurally novel moFcRH2 gene is expressed in non-lymphoid tissues. The highly restricted pattern of moFcRH3 expression suggests this member of the phylogenetically conserved FcRH family may have an important immunoregulatory role in marginal zone B cells.</description><identifier>ISSN: 0953-8178</identifier><identifier>ISSN: 1460-2377</identifier><identifier>EISSN: 1460-2377</identifier><identifier>DOI: 10.1093/intimm/dxh137</identifier><identifier>PMID: 15302849</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Amino Acid Sequence ; Animals ; B cell differentiation ; B-Lymphocytes - metabolism ; Cell Lineage ; Chromosome Mapping ; Fc receptors ; Humans ; immunoglobulin superfamily ; immunoreceptor tyrosine-based motifs ; Mice ; Molecular Sequence Data ; phylogeny ; Receptors, Fc - chemistry ; Receptors, Fc - genetics ; Receptors, Fc - physiology</subject><ispartof>International immunology, 2004-09, Vol.16 (9), p.1343-1353</ispartof><rights>Copyright Oxford University Press(England) Sep 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-475b33d0c632ed0c2a5b5f5e9776cdb648677d47445ea052a312baf24fcc69fd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15302849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davis, Randall S.</creatorcontrib><creatorcontrib>Stephan, Robert P.</creatorcontrib><creatorcontrib>Chen, Ching-Cheng</creatorcontrib><creatorcontrib>Dennis, Glynn</creatorcontrib><creatorcontrib>Cooper, Max D.</creatorcontrib><title>Differential B cell expression of mouse Fc receptor homologs</title><title>International immunology</title><addtitle>Int. Immunol</addtitle><description>Five Fc receptor homologs (FcRH1–5) possessing inhibitory and/or activating signaling motifs are differentially expressed during B cell differentiation in humans. In this analysis we describe their three mouse orthologs, moFcRH1, moFcRH2 and moFcRH3. The moFcRH genes are located in a chromosome 3 region that is syntenic with the FcRH locus on human chromosome 1. They encode proteins with 2–5 Ig-like domains that share 20–61% extracellular identity with their human counterparts. One moFcRH1 isoform lacks a transmembrane domain as do both moFcRH2 isoforms. The other moFcRH1 isoform and two moFcRH3 isoforms have transmembrane domains and cytoplasmic ITIM and ITAM-like consensus sequences implying their inhibitory or activating signaling potential. Whereas the moFcRH1 and moFcRH3 orthologs are preferentially expressed at different stages in B cell differentiation, the structurally novel moFcRH2 gene is expressed in non-lymphoid tissues. The highly restricted pattern of moFcRH3 expression suggests this member of the phylogenetically conserved FcRH family may have an important immunoregulatory role in marginal zone B cells.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>B cell differentiation</subject><subject>B-Lymphocytes - metabolism</subject><subject>Cell Lineage</subject><subject>Chromosome Mapping</subject><subject>Fc receptors</subject><subject>Humans</subject><subject>immunoglobulin superfamily</subject><subject>immunoreceptor tyrosine-based motifs</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>phylogeny</subject><subject>Receptors, Fc - chemistry</subject><subject>Receptors, Fc - genetics</subject><subject>Receptors, Fc - physiology</subject><issn>0953-8178</issn><issn>1460-2377</issn><issn>1460-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP20AUhUeoCNLAsltkdcHOzbyvLbGhoeGhCFi0FepmNB7fAYOdSWccKfz7OkpUJDaszuJ--nTuIeQLo98YLcWkWfRN103q9RMTsEdGTGqacwHwiYxoqUReMCgOyeeUnimlgpfigBwyJSgvZDkiZxeN9xhxsNg2-545bNsM18uIKTVhkQWfdWGVMJu5LKLDZR9i9hS60IbHdET2vW0THu9yTH7NfvycXuXzu8vr6fk8d1KJPpegKiFq6rTgOAS3qlJeYQmgXV1pWWiAWoKUCi1V3ArGK-u59M7p0tdiTE633mUMf1eYetM1adPULnAoZ7SGQhcgPgQZAGMg6QB-fQc-h1VcDE8YVirKgaqNLd9CLoaUInqzjE1n46th1GzGN9vxzXb8gT_ZSVdVh_UbvVv7TdikHtf_7za-GA0ClLl6-GPub5j-Pbudmrn4B7VbkAQ</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Davis, Randall S.</creator><creator>Stephan, Robert P.</creator><creator>Chen, Ching-Cheng</creator><creator>Dennis, Glynn</creator><creator>Cooper, Max D.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Differential B cell expression of mouse Fc receptor homologs</title><author>Davis, Randall S. ; Stephan, Robert P. ; Chen, Ching-Cheng ; Dennis, Glynn ; Cooper, Max D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-475b33d0c632ed0c2a5b5f5e9776cdb648677d47445ea052a312baf24fcc69fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>B cell differentiation</topic><topic>B-Lymphocytes - metabolism</topic><topic>Cell Lineage</topic><topic>Chromosome Mapping</topic><topic>Fc receptors</topic><topic>Humans</topic><topic>immunoglobulin superfamily</topic><topic>immunoreceptor tyrosine-based motifs</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>phylogeny</topic><topic>Receptors, Fc - chemistry</topic><topic>Receptors, Fc - genetics</topic><topic>Receptors, Fc - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davis, Randall S.</creatorcontrib><creatorcontrib>Stephan, Robert P.</creatorcontrib><creatorcontrib>Chen, Ching-Cheng</creatorcontrib><creatorcontrib>Dennis, Glynn</creatorcontrib><creatorcontrib>Cooper, Max D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davis, Randall S.</au><au>Stephan, Robert P.</au><au>Chen, Ching-Cheng</au><au>Dennis, Glynn</au><au>Cooper, Max D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential B cell expression of mouse Fc receptor homologs</atitle><jtitle>International immunology</jtitle><addtitle>Int. Immunol</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>16</volume><issue>9</issue><spage>1343</spage><epage>1353</epage><pages>1343-1353</pages><issn>0953-8178</issn><issn>1460-2377</issn><eissn>1460-2377</eissn><abstract>Five Fc receptor homologs (FcRH1–5) possessing inhibitory and/or activating signaling motifs are differentially expressed during B cell differentiation in humans. In this analysis we describe their three mouse orthologs, moFcRH1, moFcRH2 and moFcRH3. The moFcRH genes are located in a chromosome 3 region that is syntenic with the FcRH locus on human chromosome 1. They encode proteins with 2–5 Ig-like domains that share 20–61% extracellular identity with their human counterparts. One moFcRH1 isoform lacks a transmembrane domain as do both moFcRH2 isoforms. The other moFcRH1 isoform and two moFcRH3 isoforms have transmembrane domains and cytoplasmic ITIM and ITAM-like consensus sequences implying their inhibitory or activating signaling potential. Whereas the moFcRH1 and moFcRH3 orthologs are preferentially expressed at different stages in B cell differentiation, the structurally novel moFcRH2 gene is expressed in non-lymphoid tissues. The highly restricted pattern of moFcRH3 expression suggests this member of the phylogenetically conserved FcRH family may have an important immunoregulatory role in marginal zone B cells.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>15302849</pmid><doi>10.1093/intimm/dxh137</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals B cell differentiation B-Lymphocytes - metabolism Cell Lineage Chromosome Mapping Fc receptors Humans immunoglobulin superfamily immunoreceptor tyrosine-based motifs Mice Molecular Sequence Data phylogeny Receptors, Fc - chemistry Receptors, Fc - genetics Receptors, Fc - physiology |
| title | Differential B cell expression of mouse Fc receptor homologs |
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