Macrophages within NSCLC tumour islets are predominantly of a cytotoxic M1 phenotype associated with extended survival

There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. The primary aim of the present study was to determine the immunological phenotype of NSCLC-associated macrophages. CD68(+) macrophages expressing ma...

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Veröffentlicht in:	The European respiratory journal 2009-01, Vol.33 (1), p.118-126
Hauptverfasser:	Ohri, C. M, Shikotra, A, Green, R. H, Waller, D. A, Bradding, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antigens, Differentiation, Myelomonocytic - metabolism Biological and medical sciences Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Cohort Studies Female HLA-DR Antigens - metabolism Humans Leukocyte L1 Antigen Complex - metabolism Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Macrophages, Alveolar - metabolism Male Medical sciences Nitric Oxide Synthase Type II - metabolism Pneumology Retrospective Studies Survival Rate Tumor Necrosis Factor-alpha - metabolism Tumors of the respiratory system and mediastinum Vascular Endothelial Growth Factor A - metabolism
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