$Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system$

Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system

Clinical trials have indicated that immunoablation followed by autologous hematopoietic stem cell transplantation (ASCT) has the potential to induce clinical remission in patients with refractory systemic lupus erythematosus (SLE), but the mechanisms have remained unclear. We now report the results...

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Veröffentlicht in:	Blood 2009-01, Vol.113 (1), p.214-223
Hauptverfasser:	Alexander, Tobias, Thiel, Andreas, Rosen, Oliver, Massenkeil, Gero, Sattler, Arne, Kohler, Siegfried, Mei, Henrik, Radtke, Hartmut, Gromnica-Ihle, Erika, Burmester, Gerd-Rüdiger, Arnold, Renate, Radbruch, Andreas, Hiepe, Falk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies - blood Atrophy Autoantigens - immunology B-Lymphocytes - cytology B-Lymphocytes - immunology CD4 Antigens - metabolism Female Forkhead Transcription Factors - metabolism Hematopoietic Stem Cell Transplantation Humans Immune Tolerance - immunology Immunologic Memory - immunology Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - therapy Male Middle Aged Neutrophils - cytology Neutrophils - immunology Prospective Studies Receptors, Antigen, T-Cell - metabolism Regeneration - immunology Remission Induction T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Thymus Gland - immunology Thymus Gland - pathology Thymus Gland - physiology Transplantation, Autologous Young Adult
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