double-spliced defective hepatitis B virus genome derived from hepatocellular carcinoma tissue enhanced replication of full-length virus

In hepatitis B virus (HBV) replication cycle, pregenomic RNA undergoes splicing and the reverse transcribed defective genomes can be packaged and released. Various types of spliced defective HBV genomes have been isolated from the sera and liver tissues of viral hepatitis B patients. To explore the...

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Veröffentlicht in:	Journal of medical virology 2009-02, Vol.81 (2), p.230-237
Hauptverfasser:	Ma, Zhang-Mei, Lin, Xu, Wang, Yong-Xiang, Tian, Xiao-Chen, Xie, You-Hua, Wen, Yu-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma, Hepatocellular - virology Cell Line Culture Media - chemistry defective variant Defective Viruses - genetics DNA, Viral - analysis DNA, Viral - genetics Fundamental and applied biological sciences. Psychology Genome, Viral - genetics Genotype Hepatitis B - blood Hepatitis B - genetics Hepatitis B - virology Hepatitis B e Antigens - analysis Hepatitis B Surface Antigens - analysis Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Human viral diseases Humans Infectious diseases Liver Neoplasms - virology Male Medical sciences Microbiology Miscellaneous Molecular Sequence Data replication RNA Splicing Viral diseases Virology Virus Replication - genetics Virus Replication - immunology X protein
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