Three-dimensional power Doppler ultrasound scanning for the prediction of endometrial cancer in women with postmenopausal bleeding and thickened endometrium
Objective The purpose of this study was to evaluate the role of 3-dimensional power Doppler angiography (3D-PDA) to discriminate between benign and malignant endometrial disease in women with postmenopausal bleeding and thickened endometrium. Study Design Ninety-nine postmenopausal women (median age...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2009, Vol.200 (1), p.44.e1-44.e6 |
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| creator | Alcazar, Juan Luis, MD Galvan, Rosendo, MD |
| description | Objective The purpose of this study was to evaluate the role of 3-dimensional power Doppler angiography (3D-PDA) to discriminate between benign and malignant endometrial disease in women with postmenopausal bleeding and thickened endometrium. Study Design Ninety-nine postmenopausal women (median age, 63.1 years; range, 48-84 years) with uterine bleeding and a thickened endometrium (≥ 5 mm) at baseline transvaginal sonography were assessed by 3D-PDA before endometrial biopsy. Endometrial volume, vascularity index (VI), flow index, and vascularity-flow index were calculated with the virtual organ computer-aided analysis method. Results Histologic diagnoses were endometrial cancer (44 cases), hyperplasia (13 cases), polyp (23 cases), cystic atrophy (14 cases), and submucous myoma (5 cases). Endometrial volume, VI, and vascularity-flow index were significantly higher in malignant vs benign conditions. Receiver operating characteristic analysis revealed that VI was the best parameter for the prediction of endometrial cancer. Conclusion The findings show that 3D-PDA may be useful for the prediction of endometrial cancer in women with postmenopausal bleeding and thickened endometrium at baseline sonography. |
| doi_str_mv | 10.1016/j.ajog.2008.08.027 |
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Study Design Ninety-nine postmenopausal women (median age, 63.1 years; range, 48-84 years) with uterine bleeding and a thickened endometrium (≥ 5 mm) at baseline transvaginal sonography were assessed by 3D-PDA before endometrial biopsy. Endometrial volume, vascularity index (VI), flow index, and vascularity-flow index were calculated with the virtual organ computer-aided analysis method. Results Histologic diagnoses were endometrial cancer (44 cases), hyperplasia (13 cases), polyp (23 cases), cystic atrophy (14 cases), and submucous myoma (5 cases). Endometrial volume, VI, and vascularity-flow index were significantly higher in malignant vs benign conditions. Receiver operating characteristic analysis revealed that VI was the best parameter for the prediction of endometrial cancer. Conclusion The findings show that 3D-PDA may be useful for the prediction of endometrial cancer in women with postmenopausal bleeding and thickened endometrium at baseline sonography.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2008.08.027</identifier><identifier>PMID: 18976731</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>3-dimensional ultrasound scanning ; Aged ; Aged, 80 and over ; Angiography - methods ; Biological and medical sciences ; Biopsy ; Cardiovascular system ; Doppler analysis ; endometrial cancer ; Endometrial Neoplasms - diagnostic imaging ; Endometrial Neoplasms - pathology ; Endometrium - diagnostic imaging ; Endometrium - pathology ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Histocytochemistry ; Humans ; Imaging, Three-Dimensional - methods ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Middle Aged ; Obstetrics and Gynecology ; Postmenopause ; Prospective Studies ; ROC Curve ; Tumors ; Ultrasonic investigative techniques ; Ultrasonography, Doppler, Color - methods ; Uterine Hemorrhage - diagnostic imaging ; Uterine Hemorrhage - pathology</subject><ispartof>American journal of obstetrics and gynecology, 2009, Vol.200 (1), p.44.e1-44.e6</ispartof><rights>Mosby, Inc.</rights><rights>2009 Mosby, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-a97e7a9b9552cd887b1bcaf29e6b1da99912544f1286ce75e7890d73baced20a3</citedby><cites>FETCH-LOGICAL-c439t-a97e7a9b9552cd887b1bcaf29e6b1da99912544f1286ce75e7890d73baced20a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002937808009290$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3536,4009,4035,4036,23910,23911,25119,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21017519$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18976731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alcazar, Juan Luis, MD</creatorcontrib><creatorcontrib>Galvan, Rosendo, MD</creatorcontrib><title>Three-dimensional power Doppler ultrasound scanning for the prediction of endometrial cancer in women with postmenopausal bleeding and thickened endometrium</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective The purpose of this study was to evaluate the role of 3-dimensional power Doppler angiography (3D-PDA) to discriminate between benign and malignant endometrial disease in women with postmenopausal bleeding and thickened endometrium. Study Design Ninety-nine postmenopausal women (median age, 63.1 years; range, 48-84 years) with uterine bleeding and a thickened endometrium (≥ 5 mm) at baseline transvaginal sonography were assessed by 3D-PDA before endometrial biopsy. Endometrial volume, vascularity index (VI), flow index, and vascularity-flow index were calculated with the virtual organ computer-aided analysis method. Results Histologic diagnoses were endometrial cancer (44 cases), hyperplasia (13 cases), polyp (23 cases), cystic atrophy (14 cases), and submucous myoma (5 cases). Endometrial volume, VI, and vascularity-flow index were significantly higher in malignant vs benign conditions. Receiver operating characteristic analysis revealed that VI was the best parameter for the prediction of endometrial cancer. Conclusion The findings show that 3D-PDA may be useful for the prediction of endometrial cancer in women with postmenopausal bleeding and thickened endometrium at baseline sonography.</description><subject>3-dimensional ultrasound scanning</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angiography - methods</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Cardiovascular system</subject><subject>Doppler analysis</subject><subject>endometrial cancer</subject><subject>Endometrial Neoplasms - diagnostic imaging</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrium - diagnostic imaging</subject><subject>Endometrium - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obstetrics and Gynecology</subject><subject>Postmenopause</subject><subject>Prospective Studies</subject><subject>ROC Curve</subject><subject>Tumors</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography, Doppler, Color - methods</subject><subject>Uterine Hemorrhage - diagnostic imaging</subject><subject>Uterine Hemorrhage - pathology</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Ul2L1DAUDaK4s6N_wAfpi751TNJpk4AIy7p-wIIPrs8hTW530m2TmrQu-1_8sd4ygws-CJdcbjjnJJxzCXnF6I5R1rzrd6aPtztOqdytxcUTsmFUibKRjXxKNpRSXqpKyDNynnO_jlzx5-SMSSUaUbEN-X1zSACl8yOE7GMwQzHFe0jFxzhNA_ZlmJPJcQmuyNaE4MNt0cVUzAcopgTO2xlpRewKCC6OMCePGoi0SPahuMc7PP18QOE84xAns2TEtAMgHeUMas8Hb-8ggHuUWcYX5FlnhgwvT31Lfny6urn8Ul5_-_z18uK6tPtKzaVRAoRRraprbp2UomWtNR1X0LTMGaUU4_V-3zEuGwuiBiEVdaJqjQXHqam25O1Rd0rx5wJ51qPPFobBBIhL1k0jZFWhYVvCj0CbYs4JOj0lP5r0oBnVaya612smes1Er8VX0uuT-tKO4B4ppxAQ8OYEMGjx0CU0z-e_OI7ComYKce-POEAvfnlIOlsPaLTzCeysXfT__8eHf-h28MHji3fwALmPS8L4s2Y6c03193Vd1uWhklLFFa3-AHCIxDA</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Alcazar, Juan Luis, MD</creator><creator>Galvan, Rosendo, MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2009</creationdate><title>Three-dimensional power Doppler ultrasound scanning for the prediction of endometrial cancer in women with postmenopausal bleeding and thickened endometrium</title><author>Alcazar, Juan Luis, MD ; Galvan, Rosendo, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-a97e7a9b9552cd887b1bcaf29e6b1da99912544f1286ce75e7890d73baced20a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>3-dimensional ultrasound scanning</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angiography - methods</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Cardiovascular system</topic><topic>Doppler analysis</topic><topic>endometrial cancer</topic><topic>Endometrial Neoplasms - diagnostic imaging</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrium - diagnostic imaging</topic><topic>Endometrium - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obstetrics and Gynecology</topic><topic>Postmenopause</topic><topic>Prospective Studies</topic><topic>ROC Curve</topic><topic>Tumors</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography, Doppler, Color - methods</topic><topic>Uterine Hemorrhage - diagnostic imaging</topic><topic>Uterine Hemorrhage - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alcazar, Juan Luis, MD</creatorcontrib><creatorcontrib>Galvan, Rosendo, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alcazar, Juan Luis, MD</au><au>Galvan, Rosendo, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three-dimensional power Doppler ultrasound scanning for the prediction of endometrial cancer in women with postmenopausal bleeding and thickened endometrium</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2009</date><risdate>2009</risdate><volume>200</volume><issue>1</issue><spage>44.e1</spage><epage>44.e6</epage><pages>44.e1-44.e6</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective The purpose of this study was to evaluate the role of 3-dimensional power Doppler angiography (3D-PDA) to discriminate between benign and malignant endometrial disease in women with postmenopausal bleeding and thickened endometrium. Study Design Ninety-nine postmenopausal women (median age, 63.1 years; range, 48-84 years) with uterine bleeding and a thickened endometrium (≥ 5 mm) at baseline transvaginal sonography were assessed by 3D-PDA before endometrial biopsy. Endometrial volume, vascularity index (VI), flow index, and vascularity-flow index were calculated with the virtual organ computer-aided analysis method. Results Histologic diagnoses were endometrial cancer (44 cases), hyperplasia (13 cases), polyp (23 cases), cystic atrophy (14 cases), and submucous myoma (5 cases). Endometrial volume, VI, and vascularity-flow index were significantly higher in malignant vs benign conditions. Receiver operating characteristic analysis revealed that VI was the best parameter for the prediction of endometrial cancer. Conclusion The findings show that 3D-PDA may be useful for the prediction of endometrial cancer in women with postmenopausal bleeding and thickened endometrium at baseline sonography.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>18976731</pmid><doi>10.1016/j.ajog.2008.08.027</doi><tpages>2</tpages></addata></record> |
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| subjects | 3-dimensional ultrasound scanning Aged Aged, 80 and over Angiography - methods Biological and medical sciences Biopsy Cardiovascular system Doppler analysis endometrial cancer Endometrial Neoplasms - diagnostic imaging Endometrial Neoplasms - pathology Endometrium - diagnostic imaging Endometrium - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Histocytochemistry Humans Imaging, Three-Dimensional - methods Investigative techniques, diagnostic techniques (general aspects) Medical sciences Middle Aged Obstetrics and Gynecology Postmenopause Prospective Studies ROC Curve Tumors Ultrasonic investigative techniques Ultrasonography, Doppler, Color - methods Uterine Hemorrhage - diagnostic imaging Uterine Hemorrhage - pathology |
| title | Three-dimensional power Doppler ultrasound scanning for the prediction of endometrial cancer in women with postmenopausal bleeding and thickened endometrium |
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