Antibiotic‐treated infections in intensive care patients in the UK
Summary The purpose of this audit was to study reasons for starting antibiotic therapy, duration of antibiotic treatment, reasons for changing antibiotics and the agreement between clinical suspicion and microbiological results in intensive care practice. We conducted a multicentre observational aud...
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| Veröffentlicht in: | Anaesthesia 2004-09, Vol.59 (9), p.885-890 |
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| creator | Cuthbertson, B. H. Thompson, M. Sherry, A. Wright, M. M. Bellingan, G. J. |
| description | Summary
The purpose of this audit was to study reasons for starting antibiotic therapy, duration of antibiotic treatment, reasons for changing antibiotics and the agreement between clinical suspicion and microbiological results in intensive care practice. We conducted a multicentre observational audit of 316 patients. Data on demographic details, site, treatment and nature of infection were collected. The median duration of antibiotic therapy was 7 days. Infections were community‐acquired in 160 patients (55%). Antibiotics were started on clinical suspicion of infection in 237 patients (75%). Pulmonary infections were the most common, representing 52% of all proven infections. Gram‐negative organisms were the most common cause of proven infections (n = 90 (50%)). The antibiotic spectrum was narrowed in light of microbiology results in 78 patients (43%) and changed due to antibiotic resistance in 38 patients (21%). We conclude that the mean duration of treatment contrasts with existing published guidelines, highlighting the need for further studies on duration and efficacy of treatment in intensive care. |
| doi_str_mv | 10.1111/j.1365-2044.2004.03742.x |
| format | Article |
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The purpose of this audit was to study reasons for starting antibiotic therapy, duration of antibiotic treatment, reasons for changing antibiotics and the agreement between clinical suspicion and microbiological results in intensive care practice. We conducted a multicentre observational audit of 316 patients. Data on demographic details, site, treatment and nature of infection were collected. The median duration of antibiotic therapy was 7 days. Infections were community‐acquired in 160 patients (55%). Antibiotics were started on clinical suspicion of infection in 237 patients (75%). Pulmonary infections were the most common, representing 52% of all proven infections. Gram‐negative organisms were the most common cause of proven infections (n = 90 (50%)). The antibiotic spectrum was narrowed in light of microbiology results in 78 patients (43%) and changed due to antibiotic resistance in 38 patients (21%). We conclude that the mean duration of treatment contrasts with existing published guidelines, highlighting the need for further studies on duration and efficacy of treatment in intensive care.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.2004.03742.x</identifier><identifier>PMID: 15310352</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anti-Bacterial Agents - administration & dosage ; Antibiotics ; Bacterial Infections - drug therapy ; Biological and medical sciences ; Community-Acquired Infections - drug therapy ; Critical Care - methods ; Cross Infection - drug therapy ; Drug Administration Schedule ; Female ; Guideline Adherence ; Humans ; Infection ; Intensive care ; Male ; Medical Audit ; Medical sciences ; Middle Aged ; Practice Guidelines as Topic ; Practice Patterns, Physicians' - statistics & numerical data ; United Kingdom</subject><ispartof>Anaesthesia, 2004-09, Vol.59 (9), p.885-890</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4772-748dea89d9f7ad6a4c394d689128d2bf630aef592067082d387d63b94de59c053</citedby><cites>FETCH-LOGICAL-c4772-748dea89d9f7ad6a4c394d689128d2bf630aef592067082d387d63b94de59c053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2044.2004.03742.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2044.2004.03742.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16024551$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15310352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cuthbertson, B. H.</creatorcontrib><creatorcontrib>Thompson, M.</creatorcontrib><creatorcontrib>Sherry, A.</creatorcontrib><creatorcontrib>Wright, M. M.</creatorcontrib><creatorcontrib>Bellingan, G. J.</creatorcontrib><creatorcontrib>Intensive Care Society</creatorcontrib><creatorcontrib>the Intensive Care Society</creatorcontrib><title>Antibiotic‐treated infections in intensive care patients in the UK</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
The purpose of this audit was to study reasons for starting antibiotic therapy, duration of antibiotic treatment, reasons for changing antibiotics and the agreement between clinical suspicion and microbiological results in intensive care practice. We conducted a multicentre observational audit of 316 patients. Data on demographic details, site, treatment and nature of infection were collected. The median duration of antibiotic therapy was 7 days. Infections were community‐acquired in 160 patients (55%). Antibiotics were started on clinical suspicion of infection in 237 patients (75%). Pulmonary infections were the most common, representing 52% of all proven infections. Gram‐negative organisms were the most common cause of proven infections (n = 90 (50%)). The antibiotic spectrum was narrowed in light of microbiology results in 78 patients (43%) and changed due to antibiotic resistance in 38 patients (21%). We conclude that the mean duration of treatment contrasts with existing published guidelines, highlighting the need for further studies on duration and efficacy of treatment in intensive care.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Antibiotics</subject><subject>Bacterial Infections - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Community-Acquired Infections - drug therapy</subject><subject>Critical Care - methods</subject><subject>Cross Infection - drug therapy</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Guideline Adherence</subject><subject>Humans</subject><subject>Infection</subject><subject>Intensive care</subject><subject>Male</subject><subject>Medical Audit</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Practice Guidelines as Topic</subject><subject>Practice Patterns, Physicians' - statistics & numerical data</subject><subject>United Kingdom</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1u1DAQgC0EokvhFapc2lvC-Df2pdKqlB9RwYWeLa89Ub3KJtvY258bj8Az8iQ43RU9wsjSjDTfjEcfIRWFhpZ4v24oV7JmIETDAEQDvBWseXhBFn8bL8kCAHjNBJgj8ialNQBlmurX5IhKToFLtiAflkOOqzjm6H___JUndBlDFYcOfY7jkEpZXsYhxTusvJuw2roccchPrXyD1fXXt-RV5_qE7w75mFx_vPxx8bm--v7py8XyqvaibVndCh3QaRNM17qgnPDciKC0KWcFtuoUB4edNAxUC5oFrtug-KowKI0HyY_J2X7vdhpvd5iy3cTkse_dgOMuWaVazcGwf4IMqFFSqwLqPeinMaUJO7ud4sZNj5aCnVXbtZ2N2tmonVXbJ9X2oYyeHP7YrTYYngcPbgtwegBc8q7vJjf4mJ45BUxISQt3vufuY4-P_32AXX5bXs4l_wNgOZlq</recordid><startdate>200409</startdate><enddate>200409</enddate><creator>Cuthbertson, B. H.</creator><creator>Thompson, M.</creator><creator>Sherry, A.</creator><creator>Wright, M. M.</creator><creator>Bellingan, G. J.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200409</creationdate><title>Antibiotic‐treated infections in intensive care patients in the UK</title><author>Cuthbertson, B. H. ; Thompson, M. ; Sherry, A. ; Wright, M. M. ; Bellingan, G. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4772-748dea89d9f7ad6a4c394d689128d2bf630aef592067082d387d63b94de59c053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Antibiotics</topic><topic>Bacterial Infections - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Community-Acquired Infections - drug therapy</topic><topic>Critical Care - methods</topic><topic>Cross Infection - drug therapy</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Guideline Adherence</topic><topic>Humans</topic><topic>Infection</topic><topic>Intensive care</topic><topic>Male</topic><topic>Medical Audit</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Practice Guidelines as Topic</topic><topic>Practice Patterns, Physicians' - statistics & numerical data</topic><topic>United Kingdom</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cuthbertson, B. H.</creatorcontrib><creatorcontrib>Thompson, M.</creatorcontrib><creatorcontrib>Sherry, A.</creatorcontrib><creatorcontrib>Wright, M. M.</creatorcontrib><creatorcontrib>Bellingan, G. J.</creatorcontrib><creatorcontrib>Intensive Care Society</creatorcontrib><creatorcontrib>the Intensive Care Society</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cuthbertson, B. H.</au><au>Thompson, M.</au><au>Sherry, A.</au><au>Wright, M. 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The purpose of this audit was to study reasons for starting antibiotic therapy, duration of antibiotic treatment, reasons for changing antibiotics and the agreement between clinical suspicion and microbiological results in intensive care practice. We conducted a multicentre observational audit of 316 patients. Data on demographic details, site, treatment and nature of infection were collected. The median duration of antibiotic therapy was 7 days. Infections were community‐acquired in 160 patients (55%). Antibiotics were started on clinical suspicion of infection in 237 patients (75%). Pulmonary infections were the most common, representing 52% of all proven infections. Gram‐negative organisms were the most common cause of proven infections (n = 90 (50%)). The antibiotic spectrum was narrowed in light of microbiology results in 78 patients (43%) and changed due to antibiotic resistance in 38 patients (21%). We conclude that the mean duration of treatment contrasts with existing published guidelines, highlighting the need for further studies on duration and efficacy of treatment in intensive care.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15310352</pmid><doi>10.1111/j.1365-2044.2004.03742.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anti-Bacterial Agents - administration & dosage Antibiotics Bacterial Infections - drug therapy Biological and medical sciences Community-Acquired Infections - drug therapy Critical Care - methods Cross Infection - drug therapy Drug Administration Schedule Female Guideline Adherence Humans Infection Intensive care Male Medical Audit Medical sciences Middle Aged Practice Guidelines as Topic Practice Patterns, Physicians' - statistics & numerical data United Kingdom |
| title | Antibiotic‐treated infections in intensive care patients in the UK |
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