Helicobacter pylori mutants defective in the clpP ATP-dependant protease and the chaperone clpA display reduced macrophage and murine survival

The ATP-dependent caseinolytic proteases (Clp) are important in resistance against environmental stresses, antibiotic treatments and host immune defences for a number of pathogenic bacteria. ClpP is the proteolytic subunit, whilst ClpA acts both as a chaperone and as an ATPase driving the degradatio...

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Veröffentlicht in:	Microbial pathogenesis 2009, Vol.46 (1), p.53-57
Hauptverfasser:	Loughlin, Michael F., Arandhara, Victoria, Okolie, Charles, Aldsworth, Timothy G., Jenks, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Bacteriology Biological and medical sciences Cell Line Clp protease Disease Models, Animal Endopeptidase Clp - genetics Endopeptidase Clp - metabolism Fundamental and applied biological sciences. Psychology Helicobacter Infections - microbiology Helicobacter Infections - mortality Helicobacter pylori Helicobacter pylori - enzymology Helicobacter pylori - genetics Helicobacter pylori - growth & development Helicobacter pylori - pathogenicity Humans In vivo survival Macrophages - microbiology Mice Microbiology Miscellaneous Molecular Chaperones - genetics Molecular Chaperones - metabolism Mutation Stress resistance Virulence
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