Central Leptin Regulates Total Ceramide Content and Sterol Regulatory Element Binding Protein-1C Proteolytic Maturation in Rat White Adipose Tissue

Obesity and type 2 diabetes are associated with insulin and leptin resistance, and increased ceramide contents in target tissues. Because the adipose tissue has become a central focus in these diseases, and leptin-induced increases in insulin sensitivity may be related to effects of leptin on lipid...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-01, Vol.150 (1), p.169-178
Hauptverfasser:	Bonzón-Kulichenko, Elena, Schwudke, Dominik, Gallardo, Nilda, Moltó, Eduardo, Fernández-Agulló, Teresa, Shevchenko, Andrej, Andrés, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Animals Autonomic nervous system Biological and medical sciences Body fat Body Weight Ceramide kinase Ceramides - metabolism Cholesterol Esters - metabolism Denervation Diabetes mellitus (non-insulin dependent) Energy Intake Enzymes Fundamental and applied biological sciences. Psychology Gene expression Injections, Intraventricular Insulin Kinases Lactosylceramide a-2,3-sialyltransferase Leptin Leptin - administration & dosage Leptin - pharmacology Lipid metabolism Lipids Lipids - physiology Male Mass spectrometry Mass spectroscopy Maturation Metabolism Nervous system Phosphorylation Protein turnover Proteins Proteolysis Rats Rats, Wistar Shotguns Sphingomyelin STAT3 Transcription Factor - drug effects STAT3 Transcription Factor - metabolism Sterol Regulatory Element Binding Protein 1 - drug effects Sterol Regulatory Element Binding Protein 1 - metabolism Sterol regulatory element-binding protein Sterols Transcription Vertebrates: endocrinology
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