Alopecia areata with lymphocytic mural folliculitis affecting the isthmus in a thoroughbred mare
A 13‐year‐old, thoroughbred mare was presented with an 8‐year history of multifocal, generalized, noninflammatory alopecia and a 3‐month history of alopecia, erythema and scaling of the white star on the forehead and muzzle. Histopathological examination of biopsy samples from multiple sites on the...
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| Veröffentlicht in: | Veterinary dermatology 2004-08, Vol.15 (4), p.260-265 |
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| creator | Colombo, S Keen, J.A Brownstein, D.G Rhind, S.M McGorum, B.C Hill, P.B |
| description | A 13‐year‐old, thoroughbred mare was presented with an 8‐year history of multifocal, generalized, noninflammatory alopecia and a 3‐month history of alopecia, erythema and scaling of the white star on the forehead and muzzle. Histopathological examination of biopsy samples from multiple sites on the body (mane, neck, shoulder, flank and gluteal region) showed a subtle lymphocytic inflammatory infiltrate affecting and surrounding the anagen hair bulbs, consistent with a diagnosis of alopecia areata. The biopsy sample from the star on the forehead showed atrophic hair follicles with perifollicular and mural mononuclear folliculitis affecting the isthmus. Immunohistochemical staining with a CD3 marker confirmed the T‐lymphocytic origin of the inflammatory infiltrate in all the samples. The concurrent presence of lymphocytic infiltration at the bulbar and isthmic level of the hair follicles in the same horse is unusual. This finding may represent a variation of the histological appearance of alopecia areata. |
| doi_str_mv | 10.1111/j.1365-3164.2004.00392.x |
| format | Article |
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Histopathological examination of biopsy samples from multiple sites on the body (mane, neck, shoulder, flank and gluteal region) showed a subtle lymphocytic inflammatory infiltrate affecting and surrounding the anagen hair bulbs, consistent with a diagnosis of alopecia areata. The biopsy sample from the star on the forehead showed atrophic hair follicles with perifollicular and mural mononuclear folliculitis affecting the isthmus. Immunohistochemical staining with a CD3 marker confirmed the T‐lymphocytic origin of the inflammatory infiltrate in all the samples. The concurrent presence of lymphocytic infiltration at the bulbar and isthmic level of the hair follicles in the same horse is unusual. 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Histopathological examination of biopsy samples from multiple sites on the body (mane, neck, shoulder, flank and gluteal region) showed a subtle lymphocytic inflammatory infiltrate affecting and surrounding the anagen hair bulbs, consistent with a diagnosis of alopecia areata. The biopsy sample from the star on the forehead showed atrophic hair follicles with perifollicular and mural mononuclear folliculitis affecting the isthmus. Immunohistochemical staining with a CD3 marker confirmed the T‐lymphocytic origin of the inflammatory infiltrate in all the samples. The concurrent presence of lymphocytic infiltration at the bulbar and isthmic level of the hair follicles in the same horse is unusual. This finding may represent a variation of the histological appearance of alopecia areata.</description><subject>alopecia</subject><subject>alopecia areata</subject><subject>Alopecia Areata - complications</subject><subject>Alopecia Areata - diagnosis</subject><subject>Alopecia Areata - veterinary</subject><subject>Animals</subject><subject>Biopsy - veterinary</subject><subject>case studies</subject><subject>Diagnosis, Differential</subject><subject>disease diagnosis</subject><subject>Female</subject><subject>Folliculitis - complications</subject><subject>Folliculitis - diagnosis</subject><subject>Folliculitis - veterinary</subject><subject>hair follicles</subject><subject>histopathology</subject><subject>horse</subject><subject>horse diseases</subject><subject>Horse Diseases - diagnosis</subject><subject>Horse Diseases - pathology</subject><subject>Horses</subject><subject>immunohistochemistry</subject><subject>inflammation</subject><subject>lymphocytes</subject><subject>lymphocytic isthmic mural folliculitis</subject><subject>mares</subject><subject>medical treatment</subject><subject>skin diseases</subject><subject>symptoms</subject><issn>0959-4493</issn><issn>1365-3164</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v3CAQxVGUqNmk_Qopp9zsDMbYIOUS5b8UqYemvRKM8ZoVXjZgK9lvH5xdNddyGQTvvRn9BiFMICfpXKxyQiuWUVKVeQFQ5gBUFPn7AVr8-zhECxBMZGUp6DE6iXEFALUQ9Bs6JowCE7RcoJcr5zdGW4VVMGpU-M2OPXbbYdN7vR2txsMUlMOdd87qydnRRqy6zujRrpd47A22ceyHKWK7xio9-OCnZd8E0-IhZX5HR51y0fzY11P0fHf7fP2QPf26f7y-eso05bzIeN1wJlqlRWGE5kQIInRRNQSAcOCcQUnKgrWk7gpOW87TDA1UVCnCWsboKTrfxW6Cf51MHOVgozbOqbXxU5RVVXNSwyzkO6EOPsZgOrkJNg26lQTkDFeu5MxQzgzlDFd-wpXvyXq27zE1g2m_jHuaSXC5E7xZZ7b_HSz_3tymS7L_3Nk75aVaBhvln98FEAppkSWta_oBNuaRbQ</recordid><startdate>200408</startdate><enddate>200408</enddate><creator>Colombo, S</creator><creator>Keen, J.A</creator><creator>Brownstein, D.G</creator><creator>Rhind, S.M</creator><creator>McGorum, B.C</creator><creator>Hill, P.B</creator><general>Blackwell Publishing, Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200408</creationdate><title>Alopecia areata with lymphocytic mural folliculitis affecting the isthmus in a thoroughbred mare</title><author>Colombo, S ; Keen, J.A ; Brownstein, D.G ; Rhind, S.M ; McGorum, B.C ; Hill, P.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-87b859dac92e9c819919c26b100180885041425d17f283d88affb063aa15d553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>alopecia</topic><topic>alopecia areata</topic><topic>Alopecia Areata - complications</topic><topic>Alopecia Areata - diagnosis</topic><topic>Alopecia Areata - veterinary</topic><topic>Animals</topic><topic>Biopsy - veterinary</topic><topic>case studies</topic><topic>Diagnosis, Differential</topic><topic>disease diagnosis</topic><topic>Female</topic><topic>Folliculitis - complications</topic><topic>Folliculitis - diagnosis</topic><topic>Folliculitis - veterinary</topic><topic>hair follicles</topic><topic>histopathology</topic><topic>horse</topic><topic>horse diseases</topic><topic>Horse Diseases - diagnosis</topic><topic>Horse Diseases - pathology</topic><topic>Horses</topic><topic>immunohistochemistry</topic><topic>inflammation</topic><topic>lymphocytes</topic><topic>lymphocytic isthmic mural folliculitis</topic><topic>mares</topic><topic>medical treatment</topic><topic>skin diseases</topic><topic>symptoms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colombo, S</creatorcontrib><creatorcontrib>Keen, J.A</creatorcontrib><creatorcontrib>Brownstein, D.G</creatorcontrib><creatorcontrib>Rhind, S.M</creatorcontrib><creatorcontrib>McGorum, B.C</creatorcontrib><creatorcontrib>Hill, P.B</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colombo, S</au><au>Keen, J.A</au><au>Brownstein, D.G</au><au>Rhind, S.M</au><au>McGorum, B.C</au><au>Hill, P.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alopecia areata with lymphocytic mural folliculitis affecting the isthmus in a thoroughbred mare</atitle><jtitle>Veterinary dermatology</jtitle><addtitle>Vet Dermatol</addtitle><date>2004-08</date><risdate>2004</risdate><volume>15</volume><issue>4</issue><spage>260</spage><epage>265</epage><pages>260-265</pages><issn>0959-4493</issn><eissn>1365-3164</eissn><abstract>A 13‐year‐old, thoroughbred mare was presented with an 8‐year history of multifocal, generalized, noninflammatory alopecia and a 3‐month history of alopecia, erythema and scaling of the white star on the forehead and muzzle. Histopathological examination of biopsy samples from multiple sites on the body (mane, neck, shoulder, flank and gluteal region) showed a subtle lymphocytic inflammatory infiltrate affecting and surrounding the anagen hair bulbs, consistent with a diagnosis of alopecia areata. The biopsy sample from the star on the forehead showed atrophic hair follicles with perifollicular and mural mononuclear folliculitis affecting the isthmus. Immunohistochemical staining with a CD3 marker confirmed the T‐lymphocytic origin of the inflammatory infiltrate in all the samples. The concurrent presence of lymphocytic infiltration at the bulbar and isthmic level of the hair follicles in the same horse is unusual. This finding may represent a variation of the histological appearance of alopecia areata.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing, Ltd</pub><pmid>15305934</pmid><doi>10.1111/j.1365-3164.2004.00392.x</doi><tpages>6</tpages></addata></record> |
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| subjects | alopecia alopecia areata Alopecia Areata - complications Alopecia Areata - diagnosis Alopecia Areata - veterinary Animals Biopsy - veterinary case studies Diagnosis, Differential disease diagnosis Female Folliculitis - complications Folliculitis - diagnosis Folliculitis - veterinary hair follicles histopathology horse horse diseases Horse Diseases - diagnosis Horse Diseases - pathology Horses immunohistochemistry inflammation lymphocytes lymphocytic isthmic mural folliculitis mares medical treatment skin diseases symptoms |
| title | Alopecia areata with lymphocytic mural folliculitis affecting the isthmus in a thoroughbred mare |
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