Amyloid Precursor Protein Is a Primary Androgen Target Gene That Promotes Prostate Cancer Growth

Androgen receptor (AR) is a critical transcription factor that regulates various target genes and contributes to the pathophysiology of prostate cancer hormone dependently. Here, we identify amyloid precursor protein (APP) as a primary androgen target through chromatin immunoprecipitation (ChIP) com...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009, Vol.69 (1), p.137-142
Hauptverfasser:	TAKAYAMA, Ken-Ichi, TSUTSUMI, Shuichi, SHIRAHIGE, Katsuhiko, SASANO, Hironobu, TAKAHASHI, Satoru, KITAMURA, Tadaichi, OUCHI, Yasuyoshi, ABURATANI, Hiroyuki, INOUE, Satoshi, SUZUKI, Takashi, HORIE-INOUE, Kuniko, IKEDA, Kazuhiro, KANESHIRO, Kiyofumi, FUJIMURA, Tetsuya, KUMAGAI, Jinpei, URANO, Tomohiko, SAKAKI, Yoshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Aged Amyloid beta-Protein Precursor - biosynthesis Amyloid beta-Protein Precursor - genetics Androgens - physiology Animals Antineoplastic agents Binding Sites Biological and medical sciences Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Cell Growth Processes - physiology Chromatin Immunoprecipitation Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Histones - metabolism Humans Male Male genital diseases Medical sciences Mice Middle Aged Neoplasms, Hormone-Dependent - genetics Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Nephrology. Urinary tract diseases Pharmacology. Drug treatments Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protease Nexins Receptors, Androgen - genetics Receptors, Androgen - metabolism Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics Tumors Tumors of the urinary system Urinary tract. Prostate gland
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