Reversal of diabetes in non-immunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejection

: Background: The functional response and immunobiology of primarily non‐vascularized islet cell xenografts remain poorly defined in non‐human primates. Methods: We transplanted 20 000 adult porcine islet equivalents/kg (purified and cultured for 48‐h) intraportally into six streptozotocin‐diabet...

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Veröffentlicht in:	Xenotransplantation (Københaven) 2004-09, Vol.11 (5), p.396-407
Hauptverfasser:	Kirchhof, Nicole, Shibata, Satoshi, Wijkstrom, Martin, Kulick, David M., Salerno, Christopher T., Clemmings, Sue M., Heremans, Yves, Galili, Uri, Sutherland, David E.R., Dalmasso, Agustin P., Hering, Bernhard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Blood Glucose Diabetes Mellitus, Experimental - surgery experimental transplantation Female graft infiltrating cells Graft Rejection - immunology histology and anatomy Immunoglobulin M - analysis islets Islets of Langerhans Transplantation - immunology Islets of Langerhans Transplantation - pathology Macaca mulatta morphology non-human primates pathology Swine Transplantation Conditioning transplantation immunology and immunobiology xenotransplantation
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