Laparoscopic rectal cancer surgery with and without neoadjuvant chemo-irradiation: a comparative study
Objectives To evaluate the perioperative short-term outcomes of laparoscopic rectal cancer surgery in patients after neoadjuvant chemo-irradiation. Patients and methods This is a comparative cohort study designed to compare the perioperative and short-term outcomes of laparoscopic rectal cancer surg...
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| Veröffentlicht in: | Surgical endoscopy 2009, Vol.23 (1), p.147-152 |
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| creator | Cheung, Hester Y. S. Chung, C. C. Wong, James C. H. Yau, Kevin K. K. Li, Michael K. W. |
| description | Objectives
To evaluate the perioperative short-term outcomes of laparoscopic rectal cancer surgery in patients after neoadjuvant chemo-irradiation.
Patients and methods
This is a comparative cohort study designed to compare the perioperative and short-term outcomes of laparoscopic rectal cancer surgery in patients with and without neoadjuvant therapy. Patients undergoing elective laparoscopic rectal cancer surgery after neoadjuvant chemo-irradiation formed the study group; those receiving surgery without neoadjuvant therapy and in whom the final histology confirmed either transmural or node-positive diseases were selected as controls.
Results
Fifty-two patients in the neoadjuvant group were compared with 138 patients in the control group. Both groups were comparable in terms of American Society of Anesthesiologists (ASA) grading and gender distribution. Median operating time was significantly longer in the neoadjuvant group (155 versus 135 mins,
p
= 0.09, Mann–Whitney
U
test). No significant difference was observed in terms of blood loss, conversion rates, postoperative morbidity, length of hospital stay or sphincter preservation rates. Overall 5-year survival rates in the two groups remained similar.
Conclusions
Our data confirmed that, aside from a slightly longer operating time, laparoscopic rectal cancer surgery in patients with neoadjuvant chemo-irradiation is safe with no increased morbidity. Based on our experience, patients after neoadjuvant therapy should not be deterred from the minimally invasive approach. |
| doi_str_mv | 10.1007/s00464-008-0081-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66779962</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66779962</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-f698f32dee14fb1c5f552e3949d6c532f465d377f4224acf8039450c087199283</originalsourceid><addsrcrecordid>eNp1kU2LFDEQhoMo7rj6A7xIEPTWWpWPTsebLH7BgBc9h2w6cXvo7oxJ98rsr7fGGVwQPBRJqKfeqrzF2HOENwhg3lYA1aoGoDsGNncP2AaVFI0Q2D1kG7ASGmGsumBPat0B4Rb1Y3aBXQfCSL1haev3vuQa8n4IvMSw-JEHP4dYeF3Lj1gO_New3HA_938ueV34HLPvd-utnxcebuKUm6EU3w9-GfL8jnse8kSq9LyNvC5rf3jKHiU_1vjsfF6y7x8_fLv63Gy_fvpy9X7bBGnt0qTWdkmKPkZU6RqDTlqLKK2yfRu0FEm1upfGJCWE8iF1QDkNATqD1opOXrLXJ919yT_XWBc3DTXEcfQ081pd2xpjbSsIfPkPuMtrmWk2J9BqQGOBIDxBgRyqJSa3L8Pky8EhuOMG3GkDjtw_Bro7qnlxFl6vp9jfV5wtJ-DVGfA1-DEVMnuofzmBSJ-yijhx4iqlZlrE_YT_7_4b1Yye0w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219501790</pqid></control><display><type>article</type><title>Laparoscopic rectal cancer surgery with and without neoadjuvant chemo-irradiation: a comparative study</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Cheung, Hester Y. S. ; Chung, C. C. ; Wong, James C. H. ; Yau, Kevin K. K. ; Li, Michael K. W.</creator><creatorcontrib>Cheung, Hester Y. S. ; Chung, C. C. ; Wong, James C. H. ; Yau, Kevin K. K. ; Li, Michael K. W.</creatorcontrib><description>Objectives
To evaluate the perioperative short-term outcomes of laparoscopic rectal cancer surgery in patients after neoadjuvant chemo-irradiation.
Patients and methods
This is a comparative cohort study designed to compare the perioperative and short-term outcomes of laparoscopic rectal cancer surgery in patients with and without neoadjuvant therapy. Patients undergoing elective laparoscopic rectal cancer surgery after neoadjuvant chemo-irradiation formed the study group; those receiving surgery without neoadjuvant therapy and in whom the final histology confirmed either transmural or node-positive diseases were selected as controls.
Results
Fifty-two patients in the neoadjuvant group were compared with 138 patients in the control group. Both groups were comparable in terms of American Society of Anesthesiologists (ASA) grading and gender distribution. Median operating time was significantly longer in the neoadjuvant group (155 versus 135 mins,
p
= 0.09, Mann–Whitney
U
test). No significant difference was observed in terms of blood loss, conversion rates, postoperative morbidity, length of hospital stay or sphincter preservation rates. Overall 5-year survival rates in the two groups remained similar.
Conclusions
Our data confirmed that, aside from a slightly longer operating time, laparoscopic rectal cancer surgery in patients with neoadjuvant chemo-irradiation is safe with no increased morbidity. Based on our experience, patients after neoadjuvant therapy should not be deterred from the minimally invasive approach.</description><identifier>ISSN: 0930-2794</identifier><identifier>EISSN: 1432-2218</identifier><identifier>DOI: 10.1007/s00464-008-0081-z</identifier><identifier>PMID: 18802735</identifier><identifier>CODEN: SUREEX</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Abdominal Surgery ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents - administration & dosage ; Biological and medical sciences ; Cohort Studies ; Digestive system. Abdomen ; Dose Fractionation ; Drug Therapy, Combination ; Endoscopy ; Female ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Gynecology ; Hepatology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Laparoscopy ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoadjuvant Therapy ; Proctology ; Rectal Neoplasms - mortality ; Rectal Neoplasms - pathology ; Rectal Neoplasms - therapy ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery ; Survival Rate ; Treatment Outcome ; Tumors</subject><ispartof>Surgical endoscopy, 2009, Vol.23 (1), p.147-152</ispartof><rights>Springer Science+Business Media, LLC 2008</rights><rights>2009 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-f698f32dee14fb1c5f552e3949d6c532f465d377f4224acf8039450c087199283</citedby><cites>FETCH-LOGICAL-c399t-f698f32dee14fb1c5f552e3949d6c532f465d377f4224acf8039450c087199283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00464-008-0081-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00464-008-0081-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21103994$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18802735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheung, Hester Y. S.</creatorcontrib><creatorcontrib>Chung, C. C.</creatorcontrib><creatorcontrib>Wong, James C. H.</creatorcontrib><creatorcontrib>Yau, Kevin K. K.</creatorcontrib><creatorcontrib>Li, Michael K. W.</creatorcontrib><title>Laparoscopic rectal cancer surgery with and without neoadjuvant chemo-irradiation: a comparative study</title><title>Surgical endoscopy</title><addtitle>Surg Endosc</addtitle><addtitle>Surg Endosc</addtitle><description>Objectives
To evaluate the perioperative short-term outcomes of laparoscopic rectal cancer surgery in patients after neoadjuvant chemo-irradiation.
Patients and methods
This is a comparative cohort study designed to compare the perioperative and short-term outcomes of laparoscopic rectal cancer surgery in patients with and without neoadjuvant therapy. Patients undergoing elective laparoscopic rectal cancer surgery after neoadjuvant chemo-irradiation formed the study group; those receiving surgery without neoadjuvant therapy and in whom the final histology confirmed either transmural or node-positive diseases were selected as controls.
Results
Fifty-two patients in the neoadjuvant group were compared with 138 patients in the control group. Both groups were comparable in terms of American Society of Anesthesiologists (ASA) grading and gender distribution. Median operating time was significantly longer in the neoadjuvant group (155 versus 135 mins,
p
= 0.09, Mann–Whitney
U
test). No significant difference was observed in terms of blood loss, conversion rates, postoperative morbidity, length of hospital stay or sphincter preservation rates. Overall 5-year survival rates in the two groups remained similar.
Conclusions
Our data confirmed that, aside from a slightly longer operating time, laparoscopic rectal cancer surgery in patients with neoadjuvant chemo-irradiation is safe with no increased morbidity. Based on our experience, patients after neoadjuvant therapy should not be deterred from the minimally invasive approach.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Digestive system. Abdomen</subject><subject>Dose Fractionation</subject><subject>Drug Therapy, Combination</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Gynecology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Laparoscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoadjuvant Therapy</subject><subject>Proctology</subject><subject>Rectal Neoplasms - mortality</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - therapy</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0930-2794</issn><issn>1432-2218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU2LFDEQhoMo7rj6A7xIEPTWWpWPTsebLH7BgBc9h2w6cXvo7oxJ98rsr7fGGVwQPBRJqKfeqrzF2HOENwhg3lYA1aoGoDsGNncP2AaVFI0Q2D1kG7ASGmGsumBPat0B4Rb1Y3aBXQfCSL1haev3vuQa8n4IvMSw-JEHP4dYeF3Lj1gO_New3HA_938ueV34HLPvd-utnxcebuKUm6EU3w9-GfL8jnse8kSq9LyNvC5rf3jKHiU_1vjsfF6y7x8_fLv63Gy_fvpy9X7bBGnt0qTWdkmKPkZU6RqDTlqLKK2yfRu0FEm1upfGJCWE8iF1QDkNATqD1opOXrLXJ919yT_XWBc3DTXEcfQ081pd2xpjbSsIfPkPuMtrmWk2J9BqQGOBIDxBgRyqJSa3L8Pky8EhuOMG3GkDjtw_Bro7qnlxFl6vp9jfV5wtJ-DVGfA1-DEVMnuofzmBSJ-yijhx4iqlZlrE_YT_7_4b1Yye0w</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Cheung, Hester Y. S.</creator><creator>Chung, C. C.</creator><creator>Wong, James C. H.</creator><creator>Yau, Kevin K. K.</creator><creator>Li, Michael K. 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W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-f698f32dee14fb1c5f552e3949d6c532f465d377f4224acf8039450c087199283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Digestive system. Abdomen</topic><topic>Dose Fractionation</topic><topic>Drug Therapy, Combination</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Gynecology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Laparoscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoadjuvant Therapy</topic><topic>Proctology</topic><topic>Rectal Neoplasms - mortality</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - therapy</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheung, Hester Y. S.</creatorcontrib><creatorcontrib>Chung, C. C.</creatorcontrib><creatorcontrib>Wong, James C. H.</creatorcontrib><creatorcontrib>Yau, Kevin K. K.</creatorcontrib><creatorcontrib>Li, Michael K. W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheung, Hester Y. S.</au><au>Chung, C. C.</au><au>Wong, James C. H.</au><au>Yau, Kevin K. K.</au><au>Li, Michael K. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laparoscopic rectal cancer surgery with and without neoadjuvant chemo-irradiation: a comparative study</atitle><jtitle>Surgical endoscopy</jtitle><stitle>Surg Endosc</stitle><addtitle>Surg Endosc</addtitle><date>2009</date><risdate>2009</risdate><volume>23</volume><issue>1</issue><spage>147</spage><epage>152</epage><pages>147-152</pages><issn>0930-2794</issn><eissn>1432-2218</eissn><coden>SUREEX</coden><abstract>Objectives
To evaluate the perioperative short-term outcomes of laparoscopic rectal cancer surgery in patients after neoadjuvant chemo-irradiation.
Patients and methods
This is a comparative cohort study designed to compare the perioperative and short-term outcomes of laparoscopic rectal cancer surgery in patients with and without neoadjuvant therapy. Patients undergoing elective laparoscopic rectal cancer surgery after neoadjuvant chemo-irradiation formed the study group; those receiving surgery without neoadjuvant therapy and in whom the final histology confirmed either transmural or node-positive diseases were selected as controls.
Results
Fifty-two patients in the neoadjuvant group were compared with 138 patients in the control group. Both groups were comparable in terms of American Society of Anesthesiologists (ASA) grading and gender distribution. Median operating time was significantly longer in the neoadjuvant group (155 versus 135 mins,
p
= 0.09, Mann–Whitney
U
test). No significant difference was observed in terms of blood loss, conversion rates, postoperative morbidity, length of hospital stay or sphincter preservation rates. Overall 5-year survival rates in the two groups remained similar.
Conclusions
Our data confirmed that, aside from a slightly longer operating time, laparoscopic rectal cancer surgery in patients with neoadjuvant chemo-irradiation is safe with no increased morbidity. Based on our experience, patients after neoadjuvant therapy should not be deterred from the minimally invasive approach.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>18802735</pmid><doi>10.1007/s00464-008-0081-z</doi><tpages>6</tpages></addata></record> |
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| ispartof | Surgical endoscopy, 2009, Vol.23 (1), p.147-152 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Abdominal Surgery Adult Aged Aged, 80 and over Antineoplastic Agents - administration & dosage Biological and medical sciences Cohort Studies Digestive system. Abdomen Dose Fractionation Drug Therapy, Combination Endoscopy Female Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen General aspects Gynecology Hepatology Humans Investigative techniques, diagnostic techniques (general aspects) Laparoscopy Male Medical sciences Medicine Medicine & Public Health Middle Aged Neoadjuvant Therapy Proctology Rectal Neoplasms - mortality Rectal Neoplasms - pathology Rectal Neoplasms - therapy Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Survival Rate Treatment Outcome Tumors |
| title | Laparoscopic rectal cancer surgery with and without neoadjuvant chemo-irradiation: a comparative study |
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