Effect of sex steroids on colonic distension-induced delay of gastric emptying in rats
Background and Aim: The objective of the present study was to examine the effect of gonadal hormones on gastric motor response to non‐noxious and noxious stimuli of colonic distension. Methods: Male Wistar albino rats were used. Under ketamine anesthesia some rats underwent castration (n = 24), wh...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2004-09, Vol.19 (9), p.975-981 |
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| container_title | Journal of gastroenterology and hepatology |
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| creator | GÜNAL, ÖMER BOZKURT, AYHAN DENIZ, MUSTAFA SUNGUR, MUSTAFA YEǦ, BERRAK Ç |
| description | Background and Aim: The objective of the present study was to examine the effect of gonadal hormones on gastric motor response to non‐noxious and noxious stimuli of colonic distension.
Methods: Male Wistar albino rats were used. Under ketamine anesthesia some rats underwent castration (n = 24), while the rest of the rats were sham‐operated (n = 67) and divided into different groups (n = 7–8 per group). On the 15th day of surgery, liquid gastric emptying studies were commenced.
Results: Non‐noxious (P |
| doi_str_mv | 10.1111/j.1440-1746.2004.03409.x |
| format | Article |
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Methods: Male Wistar albino rats were used. Under ketamine anesthesia some rats underwent castration (n = 24), while the rest of the rats were sham‐operated (n = 67) and divided into different groups (n = 7–8 per group). On the 15th day of surgery, liquid gastric emptying studies were commenced.
Results: Non‐noxious (P < 0.05) or noxious (P < 0.01) colonic distension inhibited gastric emptying rate. Estradiol pretreatment (20 µg/kg per day, for 5 days, s.c.) inhibited gastric motility, while estradiol pretreatment or castration of the rats prior to noxious distension prevented the delay in gastric emptying. In contrast, blockade of testosterone receptors had no effect on the delay in gastric emptying induced by either modes of distension.
Conclusions: The results suggest that sex steroids have a modulatory role on the feedback control of gastric motility induced by noxious colonic distension.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/j.1440-1746.2004.03409.x</identifier><identifier>PMID: 15304112</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Analysis of Variance ; Animals ; Biological and medical sciences ; castration ; cologastric reflex ; Colon - physiopathology ; Dilatation, Pathologic - physiopathology ; Electromyography ; Estradiol - pharmacology ; Gastric Emptying - drug effects ; Gastroenterology. Liver. Pancreas. Abdomen ; Male ; Medical sciences ; Orchiectomy ; Rats ; Rats, Wistar ; sex steroids ; viscerovisceral reflex</subject><ispartof>Journal of gastroenterology and hepatology, 2004-09, Vol.19 (9), p.975-981</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5249-a158883790ae11a4d687eef34aff1c273e7b9f83841d59f80092368e32f9b5823</citedby><cites>FETCH-LOGICAL-c5249-a158883790ae11a4d687eef34aff1c273e7b9f83841d59f80092368e32f9b5823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1746.2004.03409.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1746.2004.03409.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16108611$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15304112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GÜNAL, ÖMER</creatorcontrib><creatorcontrib>BOZKURT, AYHAN</creatorcontrib><creatorcontrib>DENIZ, MUSTAFA</creatorcontrib><creatorcontrib>SUNGUR, MUSTAFA</creatorcontrib><creatorcontrib>YEǦ, BERRAK Ç</creatorcontrib><title>Effect of sex steroids on colonic distension-induced delay of gastric emptying in rats</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim: The objective of the present study was to examine the effect of gonadal hormones on gastric motor response to non‐noxious and noxious stimuli of colonic distension.
Methods: Male Wistar albino rats were used. Under ketamine anesthesia some rats underwent castration (n = 24), while the rest of the rats were sham‐operated (n = 67) and divided into different groups (n = 7–8 per group). On the 15th day of surgery, liquid gastric emptying studies were commenced.
Results: Non‐noxious (P < 0.05) or noxious (P < 0.01) colonic distension inhibited gastric emptying rate. Estradiol pretreatment (20 µg/kg per day, for 5 days, s.c.) inhibited gastric motility, while estradiol pretreatment or castration of the rats prior to noxious distension prevented the delay in gastric emptying. In contrast, blockade of testosterone receptors had no effect on the delay in gastric emptying induced by either modes of distension.
Conclusions: The results suggest that sex steroids have a modulatory role on the feedback control of gastric motility induced by noxious colonic distension.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>castration</subject><subject>cologastric reflex</subject><subject>Colon - physiopathology</subject><subject>Dilatation, Pathologic - physiopathology</subject><subject>Electromyography</subject><subject>Estradiol - pharmacology</subject><subject>Gastric Emptying - drug effects</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Orchiectomy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>sex steroids</subject><subject>viscerovisceral reflex</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2PEyEYh4nRuHX1XzBc9DYj78DwcfBg1t1Ws1k9-HEklIENdQoVprH972Vss3uVC29engfe_EAIA2mhrnebFhgjDQjG244Q1hLKiGoPT9Di4eApWhAJfaMoqAv0opQNqSQR_XN0AT0lDKBboB_X3js74eRxcQdcJpdTGApOEds0phgsHkLtxhJSbEIc9tYNeHCjOc7OvSlTrozb7qZjiPc4RJzNVF6iZ96Mxb0675fo-831t6tVc_tl-enqw21j-46pxkAvpaRCEeMADBu4FM55yoz3YDtBnVgrL6lkMPS1IER1lEtHO6_WvezoJXp7uneX0--9K5PehmLdOJro0r5ozoVQgogKyhNocyolO693OWxNPmoges5Ub_QcnZ6j03Om-l-m-lDV1-c39uutGx7Fc4gVeHMGTLFm9NlEG8ojx4FIDlC59yfuTxjd8b8H0J-Xq7mqfnPy5w85PPgm_9JcUNHrn3dLzXjHbj7efdUr-hdB26BB</recordid><startdate>200409</startdate><enddate>200409</enddate><creator>GÜNAL, ÖMER</creator><creator>BOZKURT, AYHAN</creator><creator>DENIZ, MUSTAFA</creator><creator>SUNGUR, MUSTAFA</creator><creator>YEǦ, BERRAK Ç</creator><general>Blackwell Science Pty</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200409</creationdate><title>Effect of sex steroids on colonic distension-induced delay of gastric emptying in rats</title><author>GÜNAL, ÖMER ; BOZKURT, AYHAN ; DENIZ, MUSTAFA ; SUNGUR, MUSTAFA ; YEǦ, BERRAK Ç</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5249-a158883790ae11a4d687eef34aff1c273e7b9f83841d59f80092368e32f9b5823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>castration</topic><topic>cologastric reflex</topic><topic>Colon - physiopathology</topic><topic>Dilatation, Pathologic - physiopathology</topic><topic>Electromyography</topic><topic>Estradiol - pharmacology</topic><topic>Gastric Emptying - drug effects</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Orchiectomy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>sex steroids</topic><topic>viscerovisceral reflex</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GÜNAL, ÖMER</creatorcontrib><creatorcontrib>BOZKURT, AYHAN</creatorcontrib><creatorcontrib>DENIZ, MUSTAFA</creatorcontrib><creatorcontrib>SUNGUR, MUSTAFA</creatorcontrib><creatorcontrib>YEǦ, BERRAK Ç</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GÜNAL, ÖMER</au><au>BOZKURT, AYHAN</au><au>DENIZ, MUSTAFA</au><au>SUNGUR, MUSTAFA</au><au>YEǦ, BERRAK Ç</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of sex steroids on colonic distension-induced delay of gastric emptying in rats</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2004-09</date><risdate>2004</risdate><volume>19</volume><issue>9</issue><spage>975</spage><epage>981</epage><pages>975-981</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim: The objective of the present study was to examine the effect of gonadal hormones on gastric motor response to non‐noxious and noxious stimuli of colonic distension.
Methods: Male Wistar albino rats were used. Under ketamine anesthesia some rats underwent castration (n = 24), while the rest of the rats were sham‐operated (n = 67) and divided into different groups (n = 7–8 per group). On the 15th day of surgery, liquid gastric emptying studies were commenced.
Results: Non‐noxious (P < 0.05) or noxious (P < 0.01) colonic distension inhibited gastric emptying rate. Estradiol pretreatment (20 µg/kg per day, for 5 days, s.c.) inhibited gastric motility, while estradiol pretreatment or castration of the rats prior to noxious distension prevented the delay in gastric emptying. In contrast, blockade of testosterone receptors had no effect on the delay in gastric emptying induced by either modes of distension.
Conclusions: The results suggest that sex steroids have a modulatory role on the feedback control of gastric motility induced by noxious colonic distension.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>15304112</pmid><doi>10.1111/j.1440-1746.2004.03409.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Biological and medical sciences castration cologastric reflex Colon - physiopathology Dilatation, Pathologic - physiopathology Electromyography Estradiol - pharmacology Gastric Emptying - drug effects Gastroenterology. Liver. Pancreas. Abdomen Male Medical sciences Orchiectomy Rats Rats, Wistar sex steroids viscerovisceral reflex |
| title | Effect of sex steroids on colonic distension-induced delay of gastric emptying in rats |
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