TRAF6‐dependent NF‐kB transcriptional activity during mouse development
Nuclear factor‐kappa B (NF‐kB) transcriptional activity is induced by numerous stimuli. To identify tissues exhibiting NF‐kB transcriptional activity during development, we analyzed transgenic reporter mice that express β‐galactosidase from an NF‐kB–responsive element. We report that NF‐kB activatio...
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| Veröffentlicht in: | Developmental dynamics 2004-09, Vol.231 (1), p.122-127 |
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| creator | Dickson, Kathleen M. Bhakar, Asha L. Barker, Philip A. |
| description | Nuclear factor‐kappa B (NF‐kB) transcriptional activity is induced by numerous stimuli. To identify tissues exhibiting NF‐kB transcriptional activity during development, we analyzed transgenic reporter mice that express β‐galactosidase from an NF‐kB–responsive element. We report that NF‐kB activation is widespread and present in numerous epithelial structures and within vasculature. Several regions of the developing central nervous system, including the roof plate and floor plate of the midbrain, show prominent NF‐kB activation. To assess the role of the TRAF6 adaptor protein in developmental NF‐kB activity, we analyzed NF‐kB activation in reporter mice rendered null for TRAF6. Deletion of TRAF6 resulted in the loss of NF‐kB activity in epithelia, in vasculature, and in roof and floor plate but had no effect on NF‐kB activity developing telencephalon, choroid plexus, cochlear canal, and thymus. These data indicate that NF‐kB transcriptional activity is present in a broad range of structures during development and that TRAF6 plays a critical role mediating developmental NF‐kB activation in many but not all tissues. Developmental Dynamics 231:122–127, 2004. © 2004 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/dvdy.20110 |
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To identify tissues exhibiting NF‐kB transcriptional activity during development, we analyzed transgenic reporter mice that express β‐galactosidase from an NF‐kB–responsive element. We report that NF‐kB activation is widespread and present in numerous epithelial structures and within vasculature. Several regions of the developing central nervous system, including the roof plate and floor plate of the midbrain, show prominent NF‐kB activation. To assess the role of the TRAF6 adaptor protein in developmental NF‐kB activity, we analyzed NF‐kB activation in reporter mice rendered null for TRAF6. Deletion of TRAF6 resulted in the loss of NF‐kB activity in epithelia, in vasculature, and in roof and floor plate but had no effect on NF‐kB activity developing telencephalon, choroid plexus, cochlear canal, and thymus. These data indicate that NF‐kB transcriptional activity is present in a broad range of structures during development and that TRAF6 plays a critical role mediating developmental NF‐kB activation in many but not all tissues. Developmental Dynamics 231:122–127, 2004. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 1058-8388</identifier><identifier>EISSN: 1097-0177</identifier><identifier>DOI: 10.1002/dvdy.20110</identifier><identifier>PMID: 15305292</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; beta-Galactosidase - metabolism ; Blood Vessels - cytology ; Blood Vessels - embryology ; Blood Vessels - metabolism ; Central Nervous System - cytology ; Central Nervous System - embryology ; Central Nervous System - metabolism ; Choroid Plexus - cytology ; Choroid Plexus - embryology ; Choroid Plexus - metabolism ; Cochlear Duct - cytology ; Cochlear Duct - embryology ; Cochlear Duct - metabolism ; endothelium ; epithelium ; Epithelium - embryology ; Epithelium - metabolism ; floor plate ; mammary gland ; Mesencephalon - cytology ; Mesencephalon - embryology ; Mesencephalon - metabolism ; Mice ; Mice, Transgenic ; NF-kappaB-Inducing Kinase ; Protein Serine-Threonine Kinases - metabolism ; roof plate ; telencephalon ; Telencephalon - cytology ; Telencephalon - embryology ; Telencephalon - metabolism ; Thymus Gland - cytology ; Thymus Gland - embryology ; Thymus Gland - metabolism ; TNF Receptor-Associated Factor 6 - metabolism ; TRAF</subject><ispartof>Developmental dynamics, 2004-09, Vol.231 (1), p.122-127</ispartof><rights>Copyright © 2004 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4270-533fd6643ccf2e5f041a9162f8c77c2c2849a50b229b169a7a48738fb866ecd13</citedby><cites>FETCH-LOGICAL-c4270-533fd6643ccf2e5f041a9162f8c77c2c2849a50b229b169a7a48738fb866ecd13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdvdy.20110$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdvdy.20110$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15305292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dickson, Kathleen M.</creatorcontrib><creatorcontrib>Bhakar, Asha L.</creatorcontrib><creatorcontrib>Barker, Philip A.</creatorcontrib><title>TRAF6‐dependent NF‐kB transcriptional activity during mouse development</title><title>Developmental dynamics</title><addtitle>Dev Dyn</addtitle><description>Nuclear factor‐kappa B (NF‐kB) transcriptional activity is induced by numerous stimuli. To identify tissues exhibiting NF‐kB transcriptional activity during development, we analyzed transgenic reporter mice that express β‐galactosidase from an NF‐kB–responsive element. We report that NF‐kB activation is widespread and present in numerous epithelial structures and within vasculature. Several regions of the developing central nervous system, including the roof plate and floor plate of the midbrain, show prominent NF‐kB activation. To assess the role of the TRAF6 adaptor protein in developmental NF‐kB activity, we analyzed NF‐kB activation in reporter mice rendered null for TRAF6. Deletion of TRAF6 resulted in the loss of NF‐kB activity in epithelia, in vasculature, and in roof and floor plate but had no effect on NF‐kB activity developing telencephalon, choroid plexus, cochlear canal, and thymus. These data indicate that NF‐kB transcriptional activity is present in a broad range of structures during development and that TRAF6 plays a critical role mediating developmental NF‐kB activation in many but not all tissues. Developmental Dynamics 231:122–127, 2004. © 2004 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>beta-Galactosidase - metabolism</subject><subject>Blood Vessels - cytology</subject><subject>Blood Vessels - embryology</subject><subject>Blood Vessels - metabolism</subject><subject>Central Nervous System - cytology</subject><subject>Central Nervous System - embryology</subject><subject>Central Nervous System - metabolism</subject><subject>Choroid Plexus - cytology</subject><subject>Choroid Plexus - embryology</subject><subject>Choroid Plexus - metabolism</subject><subject>Cochlear Duct - cytology</subject><subject>Cochlear Duct - embryology</subject><subject>Cochlear Duct - metabolism</subject><subject>endothelium</subject><subject>epithelium</subject><subject>Epithelium - embryology</subject><subject>Epithelium - metabolism</subject><subject>floor plate</subject><subject>mammary gland</subject><subject>Mesencephalon - cytology</subject><subject>Mesencephalon - embryology</subject><subject>Mesencephalon - metabolism</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>NF-kappaB-Inducing Kinase</subject><subject>Protein Serine-Threonine Kinases - metabolism</subject><subject>roof plate</subject><subject>telencephalon</subject><subject>Telencephalon - cytology</subject><subject>Telencephalon - embryology</subject><subject>Telencephalon - metabolism</subject><subject>Thymus Gland - cytology</subject><subject>Thymus Gland - embryology</subject><subject>Thymus Gland - metabolism</subject><subject>TNF Receptor-Associated Factor 6 - metabolism</subject><subject>TRAF</subject><issn>1058-8388</issn><issn>1097-0177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1KwzAUgIMobk5vfADplRdC50naJunl3JyKQ0Gm4FVIk1Sq_TNpJ73zEXxGn8TODbzzKifwnY_Dh9AxhjEGIOd6pbsxAYxhBw0xxMwHzNjueo64zwPOB-jAuVcA4DTE-2iAowAiEpMhul0-TOb0-_NLm9qU2pSNdzfvv28XXmNl6ZTN6iarSpl7UjXZKms6T7c2K1-8omqd8bRZmbyqi37zEO2lMnfmaPuO0OP8cjm99hf3VzfTycJXIWHgR0GQakrDQKmUmCiFEMsYU5JyxZgiivAwlhEkhMQJprFkMuQs4GnCKTVK42CETjfe2lbvrXGNKDKnTJ7L0vQ3CUoZ4zGEPXi2AZWtnLMmFbXNCmk7gUGs04l1OvGbrodPttY2KYz-Q7etegBvgI8sN90_KjF7mj1vpD8PX3rM</recordid><startdate>200409</startdate><enddate>200409</enddate><creator>Dickson, Kathleen M.</creator><creator>Bhakar, Asha L.</creator><creator>Barker, Philip A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200409</creationdate><title>TRAF6‐dependent NF‐kB transcriptional activity during mouse development</title><author>Dickson, Kathleen M. ; Bhakar, Asha L. ; Barker, Philip A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4270-533fd6643ccf2e5f041a9162f8c77c2c2849a50b229b169a7a48738fb866ecd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>beta-Galactosidase - metabolism</topic><topic>Blood Vessels - cytology</topic><topic>Blood Vessels - embryology</topic><topic>Blood Vessels - metabolism</topic><topic>Central Nervous System - cytology</topic><topic>Central Nervous System - embryology</topic><topic>Central Nervous System - metabolism</topic><topic>Choroid Plexus - cytology</topic><topic>Choroid Plexus - embryology</topic><topic>Choroid Plexus - metabolism</topic><topic>Cochlear Duct - cytology</topic><topic>Cochlear Duct - embryology</topic><topic>Cochlear Duct - metabolism</topic><topic>endothelium</topic><topic>epithelium</topic><topic>Epithelium - embryology</topic><topic>Epithelium - metabolism</topic><topic>floor plate</topic><topic>mammary gland</topic><topic>Mesencephalon - cytology</topic><topic>Mesencephalon - embryology</topic><topic>Mesencephalon - metabolism</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>NF-kappaB-Inducing Kinase</topic><topic>Protein Serine-Threonine Kinases - metabolism</topic><topic>roof plate</topic><topic>telencephalon</topic><topic>Telencephalon - cytology</topic><topic>Telencephalon - embryology</topic><topic>Telencephalon - metabolism</topic><topic>Thymus Gland - cytology</topic><topic>Thymus Gland - embryology</topic><topic>Thymus Gland - metabolism</topic><topic>TNF Receptor-Associated Factor 6 - metabolism</topic><topic>TRAF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dickson, Kathleen M.</creatorcontrib><creatorcontrib>Bhakar, Asha L.</creatorcontrib><creatorcontrib>Barker, Philip A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dickson, Kathleen M.</au><au>Bhakar, Asha L.</au><au>Barker, Philip A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TRAF6‐dependent NF‐kB transcriptional activity during mouse development</atitle><jtitle>Developmental dynamics</jtitle><addtitle>Dev Dyn</addtitle><date>2004-09</date><risdate>2004</risdate><volume>231</volume><issue>1</issue><spage>122</spage><epage>127</epage><pages>122-127</pages><issn>1058-8388</issn><eissn>1097-0177</eissn><abstract>Nuclear factor‐kappa B (NF‐kB) transcriptional activity is induced by numerous stimuli. To identify tissues exhibiting NF‐kB transcriptional activity during development, we analyzed transgenic reporter mice that express β‐galactosidase from an NF‐kB–responsive element. We report that NF‐kB activation is widespread and present in numerous epithelial structures and within vasculature. Several regions of the developing central nervous system, including the roof plate and floor plate of the midbrain, show prominent NF‐kB activation. To assess the role of the TRAF6 adaptor protein in developmental NF‐kB activity, we analyzed NF‐kB activation in reporter mice rendered null for TRAF6. Deletion of TRAF6 resulted in the loss of NF‐kB activity in epithelia, in vasculature, and in roof and floor plate but had no effect on NF‐kB activity developing telencephalon, choroid plexus, cochlear canal, and thymus. These data indicate that NF‐kB transcriptional activity is present in a broad range of structures during development and that TRAF6 plays a critical role mediating developmental NF‐kB activation in many but not all tissues. Developmental Dynamics 231:122–127, 2004. © 2004 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15305292</pmid><doi>10.1002/dvdy.20110</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals beta-Galactosidase - metabolism Blood Vessels - cytology Blood Vessels - embryology Blood Vessels - metabolism Central Nervous System - cytology Central Nervous System - embryology Central Nervous System - metabolism Choroid Plexus - cytology Choroid Plexus - embryology Choroid Plexus - metabolism Cochlear Duct - cytology Cochlear Duct - embryology Cochlear Duct - metabolism endothelium epithelium Epithelium - embryology Epithelium - metabolism floor plate mammary gland Mesencephalon - cytology Mesencephalon - embryology Mesencephalon - metabolism Mice Mice, Transgenic NF-kappaB-Inducing Kinase Protein Serine-Threonine Kinases - metabolism roof plate telencephalon Telencephalon - cytology Telencephalon - embryology Telencephalon - metabolism Thymus Gland - cytology Thymus Gland - embryology Thymus Gland - metabolism TNF Receptor-Associated Factor 6 - metabolism TRAF |
| title | TRAF6‐dependent NF‐kB transcriptional activity during mouse development |
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