Cytotoxic Activity of Maytanprine Isolated from Maytenus diversifolia in Human Leukemia K562 Cells

We examined the cytotoxic effect of maytanprine isolated from the methanol extract of Maytenus diversifolia on human leukemia K562 cells using a flow cytometer and compared its cytotoxicity with that of maytansine, a potent cytotoxic maytansinoid. Maytanprine at concentrations of 0.03 nM or more (up...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2004, Vol.27(8), pp.1236-1240
Hauptverfasser:	Nakao, Hiromi, Senokuchi, Kaori, Umebayashi, Chisato, Kanemaru, Kaori, Masuda, Toshiya, Oyama, Yasuo, Yonemori, Shigetomo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Cell Division - drug effects cytotoxicity Flow Cytometry human leukemia K562 cell Humans K562 Cells maytanprine Maytansine - analogs & derivatives Maytansine - isolation & purification Maytansine - pharmacology Maytenus diversifolia
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