Early clinical pregnancy loss rate in poor responder patients does not change compared to age-matched normoresponders
Objective To investigate the early clinical pregnancy loss rate (ECPLR) of singleton gestations in poor responder (PR) patients. Design A retrospective study. Setting Private assisted reproductive technology center. Patient(s) A total of 2,157 singleton clinical pregnancies were identified, 195 from...
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| Veröffentlicht in: | Fertility and sterility 2009, Vol.91 (1), p.106-109 |
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| creator | Kumbak, Banu, M.D Ulug, Ulun, M.D Erzik, Burcak, M.D Akbas, Hande, M.D Bahceci, Mustafa, M.D |
| description | Objective To investigate the early clinical pregnancy loss rate (ECPLR) of singleton gestations in poor responder (PR) patients. Design A retrospective study. Setting Private assisted reproductive technology center. Patient(s) A total of 2,157 singleton clinical pregnancies were identified, 195 from PR and 1,962 from normoresponder (NR) patients. Poor response was accepted as retrieval of four or fewer oocytes. Patients who yielded more than five oocytes were accepted as NR control group. Intervention(s) Patients were age stratified as ≤35, 36–39, and ≥40 years. Main Outcome Measure(s) Comparative evaluation of ECPLR in PR and NR patients according to age. Results Out of 195 singleton clinical pregnancies achieved in poor responders, 31% resulted in early clinical pregnancy loss; ECPLR were 22%, 32%, and 59% in the ≤35, 36–39, and ≥40 year age groups, respectively. When ECPLR in singleton gestations of PR patients was compared with that of NR patients according to age, no significant differences were found for all age groups. Conclusion(s) Early clinical pregnancy loss rate was not found to differ significantly between PR and NR patients at all age groups. Therefore, PR patients should be counseled about their lower probability of clinical pregnancy but similar ECPLR compared with their age-matched NR counterparts. |
| doi_str_mv | 10.1016/j.fertnstert.2007.11.009 |
| format | Article |
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Design A retrospective study. Setting Private assisted reproductive technology center. Patient(s) A total of 2,157 singleton clinical pregnancies were identified, 195 from PR and 1,962 from normoresponder (NR) patients. Poor response was accepted as retrieval of four or fewer oocytes. Patients who yielded more than five oocytes were accepted as NR control group. Intervention(s) Patients were age stratified as ≤35, 36–39, and ≥40 years. Main Outcome Measure(s) Comparative evaluation of ECPLR in PR and NR patients according to age. Results Out of 195 singleton clinical pregnancies achieved in poor responders, 31% resulted in early clinical pregnancy loss; ECPLR were 22%, 32%, and 59% in the ≤35, 36–39, and ≥40 year age groups, respectively. When ECPLR in singleton gestations of PR patients was compared with that of NR patients according to age, no significant differences were found for all age groups. Conclusion(s) Early clinical pregnancy loss rate was not found to differ significantly between PR and NR patients at all age groups. Therefore, PR patients should be counseled about their lower probability of clinical pregnancy but similar ECPLR compared with their age-matched NR counterparts.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2007.11.009</identifier><identifier>PMID: 18249385</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Abortion, Spontaneous - epidemiology ; Abortion, Spontaneous - genetics ; Adult ; Age Factors ; Aneuploidy ; Biological and medical sciences ; clinical abortion ; Diseases of mother, fetus and pregnancy ; early pregnancy loss ; Female ; Fertilization in Vitro - methods ; Fertilization in Vitro - statistics & numerical data ; Gynecology. Andrology. Obstetrics ; Humans ; ICSI ; Internal Medicine ; IVF ; Male ; Medical sciences ; Obstetrics and Gynecology ; Oocyte Retrieval - methods ; Poor responder ; Pregnancy ; Pregnancy Outcome ; Pregnancy. Fetus. Placenta ; Prognosis ; Turkey ; Ultrasonography, Prenatal</subject><ispartof>Fertility and sterility, 2009, Vol.91 (1), p.106-109</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2009 American Society for Reproductive Medicine</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-c00667ba448426296874cb2a6317fc4435941d980e3b0ffb67eda78fb61a7c6e3</citedby><cites>FETCH-LOGICAL-c507t-c00667ba448426296874cb2a6317fc4435941d980e3b0ffb67eda78fb61a7c6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S001502820703974X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,4009,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21002172$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18249385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumbak, Banu, M.D</creatorcontrib><creatorcontrib>Ulug, Ulun, M.D</creatorcontrib><creatorcontrib>Erzik, Burcak, M.D</creatorcontrib><creatorcontrib>Akbas, Hande, M.D</creatorcontrib><creatorcontrib>Bahceci, Mustafa, M.D</creatorcontrib><title>Early clinical pregnancy loss rate in poor responder patients does not change compared to age-matched normoresponders</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To investigate the early clinical pregnancy loss rate (ECPLR) of singleton gestations in poor responder (PR) patients. Design A retrospective study. Setting Private assisted reproductive technology center. Patient(s) A total of 2,157 singleton clinical pregnancies were identified, 195 from PR and 1,962 from normoresponder (NR) patients. Poor response was accepted as retrieval of four or fewer oocytes. Patients who yielded more than five oocytes were accepted as NR control group. Intervention(s) Patients were age stratified as ≤35, 36–39, and ≥40 years. Main Outcome Measure(s) Comparative evaluation of ECPLR in PR and NR patients according to age. Results Out of 195 singleton clinical pregnancies achieved in poor responders, 31% resulted in early clinical pregnancy loss; ECPLR were 22%, 32%, and 59% in the ≤35, 36–39, and ≥40 year age groups, respectively. When ECPLR in singleton gestations of PR patients was compared with that of NR patients according to age, no significant differences were found for all age groups. Conclusion(s) Early clinical pregnancy loss rate was not found to differ significantly between PR and NR patients at all age groups. Therefore, PR patients should be counseled about their lower probability of clinical pregnancy but similar ECPLR compared with their age-matched NR counterparts.</description><subject>Abortion, Spontaneous - epidemiology</subject><subject>Abortion, Spontaneous - genetics</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>clinical abortion</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>early pregnancy loss</subject><subject>Female</subject><subject>Fertilization in Vitro - methods</subject><subject>Fertilization in Vitro - statistics & numerical data</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>ICSI</subject><subject>Internal Medicine</subject><subject>IVF</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Obstetrics and Gynecology</subject><subject>Oocyte Retrieval - methods</subject><subject>Poor responder</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prognosis</subject><subject>Turkey</subject><subject>Ultrasonography, Prenatal</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQQC0Eokvbv4B8gVvC2Ens5IIEVaGVKnFokbhZjjPZeknsYDtI--_xapdW4oQP_pDejMdvTAhlUDJg4sOuHDEkF1OeSw4gS8ZKgO4F2bCmEUUjmuol2QCwpgDe8jPyJsYdAAgm-Wtyxlped1XbbMh6rcO0p2ayzho90SXg1mln9nTyMdKgE1Lr6OJ9oAHj4t2AgS46WXQp0sFjpM4nah612yI1fl50wIEmT_UWi1kn85iPzofZP8XHC_Jq1FPEy9N6Tr5_uX64uinuvn29vfp0V5gGZCpMLljIXtd1W3PBO9HK2vRci4rJ0dR11XQ1G7oWsOphHHshcdCyzRumpRFYnZP3x7xL8L9WjEnNNhqcJu3Qr1Hl7HkAy2B7BE3Izw44qiXYWYe9YqAOytVOPStXB-WKMZWV59C3pzvWfsbhOfDkOAPvToCOWfEYsl4bnzjOAHhuS-Y-HznMRn5bDCqabNngYAOapAZv_6eaj_8k-dvan7jHuPNrcNm4YipyBer-8EUOPwQkVJ2sf1R_AExEu-w</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Kumbak, Banu, M.D</creator><creator>Ulug, Ulun, M.D</creator><creator>Erzik, Burcak, M.D</creator><creator>Akbas, Hande, M.D</creator><creator>Bahceci, Mustafa, M.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2009</creationdate><title>Early clinical pregnancy loss rate in poor responder patients does not change compared to age-matched normoresponders</title><author>Kumbak, Banu, M.D ; Ulug, Ulun, M.D ; Erzik, Burcak, M.D ; Akbas, Hande, M.D ; Bahceci, Mustafa, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-c00667ba448426296874cb2a6317fc4435941d980e3b0ffb67eda78fb61a7c6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Abortion, Spontaneous - epidemiology</topic><topic>Abortion, Spontaneous - genetics</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>clinical abortion</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>early pregnancy loss</topic><topic>Female</topic><topic>Fertilization in Vitro - methods</topic><topic>Fertilization in Vitro - statistics & numerical data</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>ICSI</topic><topic>Internal Medicine</topic><topic>IVF</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Obstetrics and Gynecology</topic><topic>Oocyte Retrieval - methods</topic><topic>Poor responder</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prognosis</topic><topic>Turkey</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumbak, Banu, M.D</creatorcontrib><creatorcontrib>Ulug, Ulun, M.D</creatorcontrib><creatorcontrib>Erzik, Burcak, M.D</creatorcontrib><creatorcontrib>Akbas, Hande, M.D</creatorcontrib><creatorcontrib>Bahceci, Mustafa, M.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumbak, Banu, M.D</au><au>Ulug, Ulun, M.D</au><au>Erzik, Burcak, M.D</au><au>Akbas, Hande, M.D</au><au>Bahceci, Mustafa, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early clinical pregnancy loss rate in poor responder patients does not change compared to age-matched normoresponders</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2009</date><risdate>2009</risdate><volume>91</volume><issue>1</issue><spage>106</spage><epage>109</epage><pages>106-109</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective To investigate the early clinical pregnancy loss rate (ECPLR) of singleton gestations in poor responder (PR) patients. Design A retrospective study. Setting Private assisted reproductive technology center. Patient(s) A total of 2,157 singleton clinical pregnancies were identified, 195 from PR and 1,962 from normoresponder (NR) patients. Poor response was accepted as retrieval of four or fewer oocytes. Patients who yielded more than five oocytes were accepted as NR control group. Intervention(s) Patients were age stratified as ≤35, 36–39, and ≥40 years. Main Outcome Measure(s) Comparative evaluation of ECPLR in PR and NR patients according to age. Results Out of 195 singleton clinical pregnancies achieved in poor responders, 31% resulted in early clinical pregnancy loss; ECPLR were 22%, 32%, and 59% in the ≤35, 36–39, and ≥40 year age groups, respectively. When ECPLR in singleton gestations of PR patients was compared with that of NR patients according to age, no significant differences were found for all age groups. Conclusion(s) Early clinical pregnancy loss rate was not found to differ significantly between PR and NR patients at all age groups. Therefore, PR patients should be counseled about their lower probability of clinical pregnancy but similar ECPLR compared with their age-matched NR counterparts.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18249385</pmid><doi>10.1016/j.fertnstert.2007.11.009</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 2009, Vol.91 (1), p.106-109 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Abortion, Spontaneous - epidemiology Abortion, Spontaneous - genetics Adult Age Factors Aneuploidy Biological and medical sciences clinical abortion Diseases of mother, fetus and pregnancy early pregnancy loss Female Fertilization in Vitro - methods Fertilization in Vitro - statistics & numerical data Gynecology. Andrology. Obstetrics Humans ICSI Internal Medicine IVF Male Medical sciences Obstetrics and Gynecology Oocyte Retrieval - methods Poor responder Pregnancy Pregnancy Outcome Pregnancy. Fetus. Placenta Prognosis Turkey Ultrasonography, Prenatal |
| title | Early clinical pregnancy loss rate in poor responder patients does not change compared to age-matched normoresponders |
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