Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

In human neuroblastoma, amplification of the MYCN gene predicts poor prognosis and resistance to therapy. In a shRNA screen of genes that are highly expressed in MYCN-amplified tumors, we have identified AURKA as a gene that is required for the growth of MYCN-amplified neuroblastoma cells but largel...

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Veröffentlicht in:	Cancer cell 2009-01, Vol.15 (1), p.67-78
Hauptverfasser:	Otto, Tobias, Horn, Sebastian, Brockmann, Markus, Eilers, Ursula, Schüttrumpf, Lars, Popov, Nikita, Kenney, Anna Marie, Schulte, Johannes H., Beijersbergen, Roderick, Christiansen, Holger, Berwanger, Bernd, Eilers, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aurora Kinase A Aurora Kinases Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Proliferation CELLBIO F-Box Proteins - metabolism F-Box-WD Repeat-Containing Protein 7 Humans HUMDISEASE Neuroblastoma - genetics Neuroblastoma - metabolism Neuroblastoma - pathology Protein Binding Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism RNA Interference SIGNALING Ubiquitin-Protein Ligases - metabolism
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