Genetic variation of the dihydrofolate reductase gene in Plasmodium vivax in Snoul, northeastern Cambodia

In Plasmodium vivax, pyrimethamine resistance is associated with amino acid substitutions Ser117Asn and Ser58Arg in dihydrofolate reductase (DHFR), which correspond to Ser108Asn and Cys59Arg in the Plasmodium falciparum homolog, respectively. Sequence variations within the DHFR domain of 32 P. vivax...

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Veröffentlicht in:	Acta tropica 2004-09, Vol.92 (1), p.1-6
Hauptverfasser:	de Pécoulas, Philippe Eldin, Tahar, Rachida, Yi, Poravuth, Thai, Khieng Heng, Basco, Leonardo K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifolate drugs Antimalarials - therapeutic use Biological and medical sciences Cambodia Chloroquine Drug resistance Drug Resistance, Microbial - genetics Genetic Variation - genetics Human protozoal diseases Humans Infectious diseases Malaria Malaria, Vivax - drug therapy Medical sciences Mutation Parasitic diseases Plasmodium falciparum Plasmodium vivax Plasmodium vivax - genetics Polymorphism, Genetic Protozoal diseases Pyrimethamine - therapeutic use Tetrahydrofolate Dehydrogenase - genetics
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