A Simple Mycobacterial Monomycolated Glycerol Lipid Has Potent Immunostimulatory Activity

It is a long held belief that the strong immunostimulatory activity of the Mycobacterium bovis bacillus Calmette-Guérin vaccine and Freund's complete adjuvant is due to specific mycobacterial cell envelope components, such as lipids and polysaccharides. Implicated mycobacterial lipids include,...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-01, Vol.182 (1), p.424-432
Hauptverfasser:	Andersen, Claire S, Agger, Else Marie, Rosenkrands, Ida, Gomes, Jessica M, Bhowruth, Veemal, Gibson, Kevin J. C, Petersen, Rune V, Minnikin, David E, Besra, Gurdyal S, Andersen, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - pharmacology Animals BCG Vaccine - administration & dosage BCG Vaccine - immunology Cells, Cultured Cord Factors - administration & dosage Cord Factors - immunology Corynebacterium diphtheriae - immunology Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - microbiology Female Glycerol - immunology Glycolipids - immunology Humans Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Mycobacterium bovis - chemistry Mycobacterium bovis - immunology Mycobacterium tuberculosis - immunology Mycolic Acids - administration & dosage Mycolic Acids - immunology Th1 Cells - immunology Th1 Cells - metabolism Th1 Cells - microbiology
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