Intrathecal cdk5 inhibitor, roscovitine, attenuates morphine antinociceptive tolerance in rats
To investigate the effect of cyclin-dependent kinase 5 (Cdk5) inhibitor roscovitine on the morphine antinociceptive tolerance development in rats. Tail-flick test as pain threshold measurement and intrathecal injection techniques were used. Intrathecal roscovitine infusion alone produced an antinoci...
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| Veröffentlicht in: | Acta pharmacologica Sinica 2004-08, Vol.25 (8), p.1027-1030 |
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| container_title | Acta pharmacologica Sinica |
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| creator | Wang, Cheng-Haung Lee, Tsung-Hsing Tsai, Yi-Jung Liu, Jong-Kang Chen, Yann-Jang Yang, Lin-Cheng Lu, Cheng-Yuang |
| description | To investigate the effect of cyclin-dependent kinase 5 (Cdk5) inhibitor roscovitine on the morphine antinociceptive tolerance development in rats.
Tail-flick test as pain threshold measurement and intrathecal injection techniques were used.
Intrathecal roscovitine infusion alone produced an antinociceptive effect. Tolerance was induced by continuous intrathecal infusion of morphine 5 microg/h for 5 d. Co-administration of intrathecal roscovitine 1 microg/h for 5 d enhanced the morphine antinociceptive effect in tolerant rats. It also caused a shift in the morphine antinociceptive dose-response curve to the left when co-administered with morphine during tolerance induction, and caused a 67 % reduction in the increase in the ED50 of morphine (dose producing 50 % of the maximum response).
Cdk5 modulation is involved in the antinociceptive tolerance of morphine. Intrathecal roscovitine administration could attenuate this tolerance development. |
| format | Article |
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Tail-flick test as pain threshold measurement and intrathecal injection techniques were used.
Intrathecal roscovitine infusion alone produced an antinociceptive effect. Tolerance was induced by continuous intrathecal infusion of morphine 5 microg/h for 5 d. Co-administration of intrathecal roscovitine 1 microg/h for 5 d enhanced the morphine antinociceptive effect in tolerant rats. It also caused a shift in the morphine antinociceptive dose-response curve to the left when co-administered with morphine during tolerance induction, and caused a 67 % reduction in the increase in the ED50 of morphine (dose producing 50 % of the maximum response).
Cdk5 modulation is involved in the antinociceptive tolerance of morphine. Intrathecal roscovitine administration could attenuate this tolerance development.</description><identifier>ISSN: 1671-4083</identifier><identifier>PMID: 15301735</identifier><language>eng</language><publisher>United States</publisher><subject>Analgesics, Opioid - pharmacology ; Animals ; Cyclin-Dependent Kinase 5 ; Cyclin-Dependent Kinases - antagonists & inhibitors ; Drug Tolerance ; Injections, Spinal ; Male ; Morphine - pharmacology ; Pain Measurement ; Pain Threshold - drug effects ; Purines - administration & dosage ; Purines - pharmacology ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Acta pharmacologica Sinica, 2004-08, Vol.25 (8), p.1027-1030</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15301735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Cheng-Haung</creatorcontrib><creatorcontrib>Lee, Tsung-Hsing</creatorcontrib><creatorcontrib>Tsai, Yi-Jung</creatorcontrib><creatorcontrib>Liu, Jong-Kang</creatorcontrib><creatorcontrib>Chen, Yann-Jang</creatorcontrib><creatorcontrib>Yang, Lin-Cheng</creatorcontrib><creatorcontrib>Lu, Cheng-Yuang</creatorcontrib><title>Intrathecal cdk5 inhibitor, roscovitine, attenuates morphine antinociceptive tolerance in rats</title><title>Acta pharmacologica Sinica</title><addtitle>Acta Pharmacol Sin</addtitle><description>To investigate the effect of cyclin-dependent kinase 5 (Cdk5) inhibitor roscovitine on the morphine antinociceptive tolerance development in rats.
Tail-flick test as pain threshold measurement and intrathecal injection techniques were used.
Intrathecal roscovitine infusion alone produced an antinociceptive effect. Tolerance was induced by continuous intrathecal infusion of morphine 5 microg/h for 5 d. Co-administration of intrathecal roscovitine 1 microg/h for 5 d enhanced the morphine antinociceptive effect in tolerant rats. It also caused a shift in the morphine antinociceptive dose-response curve to the left when co-administered with morphine during tolerance induction, and caused a 67 % reduction in the increase in the ED50 of morphine (dose producing 50 % of the maximum response).
Cdk5 modulation is involved in the antinociceptive tolerance of morphine. Intrathecal roscovitine administration could attenuate this tolerance development.</description><subject>Analgesics, Opioid - pharmacology</subject><subject>Animals</subject><subject>Cyclin-Dependent Kinase 5</subject><subject>Cyclin-Dependent Kinases - antagonists & inhibitors</subject><subject>Drug Tolerance</subject><subject>Injections, Spinal</subject><subject>Male</subject><subject>Morphine - pharmacology</subject><subject>Pain Measurement</subject><subject>Pain Threshold - drug effects</subject><subject>Purines - administration & dosage</subject><subject>Purines - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>1671-4083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtLxDAYRbNQnHH0L0hWrqaQx6RJlzL4GBhwo1tLkn6h0TapSTrgv7fguLpw7-Es7gVa01rSakcUX6HrnD8J4YzT5gqtqOCESi7W6OMQStKlB6sHbLsvgX3ovfElpi1OMdt48sUH2GJdCoRZF8h4jGnqlxLrsGzRegtT8SfAJQ6QdLCwWPCizTfo0ukhw-05N-j96fFt_1IdX58P-4djNTEiS8U6QgXsnCG848o6xjpjrDFUNcoJIghzRFJplGK1W-BGCUVqbQRVVOqO8A26__NOKX7PkEs7-mxhGHSAOOe2rqWsWSMW8O4MzmaErp2SH3X6af8f4b8x4V0e</recordid><startdate>200408</startdate><enddate>200408</enddate><creator>Wang, Cheng-Haung</creator><creator>Lee, Tsung-Hsing</creator><creator>Tsai, Yi-Jung</creator><creator>Liu, Jong-Kang</creator><creator>Chen, Yann-Jang</creator><creator>Yang, Lin-Cheng</creator><creator>Lu, Cheng-Yuang</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200408</creationdate><title>Intrathecal cdk5 inhibitor, roscovitine, attenuates morphine antinociceptive tolerance in rats</title><author>Wang, Cheng-Haung ; Lee, Tsung-Hsing ; Tsai, Yi-Jung ; Liu, Jong-Kang ; Chen, Yann-Jang ; Yang, Lin-Cheng ; Lu, Cheng-Yuang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p207t-2d015e4fb03d38cf22dbbcbb1898f50502f0717b8826f2d0985806ab51817ad03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analgesics, Opioid - pharmacology</topic><topic>Animals</topic><topic>Cyclin-Dependent Kinase 5</topic><topic>Cyclin-Dependent Kinases - antagonists & inhibitors</topic><topic>Drug Tolerance</topic><topic>Injections, Spinal</topic><topic>Male</topic><topic>Morphine - pharmacology</topic><topic>Pain Measurement</topic><topic>Pain Threshold - drug effects</topic><topic>Purines - administration & dosage</topic><topic>Purines - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Cheng-Haung</creatorcontrib><creatorcontrib>Lee, Tsung-Hsing</creatorcontrib><creatorcontrib>Tsai, Yi-Jung</creatorcontrib><creatorcontrib>Liu, Jong-Kang</creatorcontrib><creatorcontrib>Chen, Yann-Jang</creatorcontrib><creatorcontrib>Yang, Lin-Cheng</creatorcontrib><creatorcontrib>Lu, Cheng-Yuang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta pharmacologica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Cheng-Haung</au><au>Lee, Tsung-Hsing</au><au>Tsai, Yi-Jung</au><au>Liu, Jong-Kang</au><au>Chen, Yann-Jang</au><au>Yang, Lin-Cheng</au><au>Lu, Cheng-Yuang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrathecal cdk5 inhibitor, roscovitine, attenuates morphine antinociceptive tolerance in rats</atitle><jtitle>Acta pharmacologica Sinica</jtitle><addtitle>Acta Pharmacol Sin</addtitle><date>2004-08</date><risdate>2004</risdate><volume>25</volume><issue>8</issue><spage>1027</spage><epage>1030</epage><pages>1027-1030</pages><issn>1671-4083</issn><abstract>To investigate the effect of cyclin-dependent kinase 5 (Cdk5) inhibitor roscovitine on the morphine antinociceptive tolerance development in rats.
Tail-flick test as pain threshold measurement and intrathecal injection techniques were used.
Intrathecal roscovitine infusion alone produced an antinociceptive effect. Tolerance was induced by continuous intrathecal infusion of morphine 5 microg/h for 5 d. Co-administration of intrathecal roscovitine 1 microg/h for 5 d enhanced the morphine antinociceptive effect in tolerant rats. It also caused a shift in the morphine antinociceptive dose-response curve to the left when co-administered with morphine during tolerance induction, and caused a 67 % reduction in the increase in the ED50 of morphine (dose producing 50 % of the maximum response).
Cdk5 modulation is involved in the antinociceptive tolerance of morphine. Intrathecal roscovitine administration could attenuate this tolerance development.</abstract><cop>United States</cop><pmid>15301735</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Acta pharmacologica Sinica, 2004-08, Vol.25 (8), p.1027-1030 |
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| source | MEDLINE; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Analgesics, Opioid - pharmacology Animals Cyclin-Dependent Kinase 5 Cyclin-Dependent Kinases - antagonists & inhibitors Drug Tolerance Injections, Spinal Male Morphine - pharmacology Pain Measurement Pain Threshold - drug effects Purines - administration & dosage Purines - pharmacology Rats Rats, Sprague-Dawley |
| title | Intrathecal cdk5 inhibitor, roscovitine, attenuates morphine antinociceptive tolerance in rats |
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