Brain Natriuretic Peptide and Exercise Capacity in Lung Fibrosis and Pulmonary Hypertension
Pulmonary hypertension (PH) can develop in lung fibrosis, and contributes to increased morbidity and mortality. Noninvasive parameters in the evaluation of PH in lung disease could aid in the management of these subjects. In this study, we aimed to characterize the role of brain natriuretic peptide...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2004-08, Vol.170 (4), p.360-365 |
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| creator | Leuchte, Hanno H Neurohr, Claus Baumgartner, Rainer Holzapfel, Michael Giehrl, Wolfgang Vogeser, Michael Behr, Jurgen |
| description | Pulmonary hypertension (PH) can develop in lung fibrosis, and contributes to increased morbidity and mortality. Noninvasive parameters in the evaluation of PH in lung disease could aid in the management of these subjects. In this study, we aimed to characterize the role of brain natriuretic peptide (BNP) and the six-minute walk distance (6-MWD) in the assessment of pulmonary hypertension (PH) in subjects with lung fibrosis. Subjects with lung fibrosis and elevated BNP levels (n = 20) had significantly more severe PH during right heart catheterization than those with lung fibrosis, and normal BNP levels (mean pulmonary arterial pressure (40.85 +/- 3.2 mm Hg vs. 23.42+/-1.44 mm Hg, respectively) (n = 19) (p < 0.001). Significant correlations between lung volumes and BNP concentrations were not observed. A weak correlation existed between capillary pO(2) and 6-MWD (r = 0.42; p < 0.001). The presence of moderate-severe PH was associated with significant reduction of the 6-MWD. BNP concentrations predicted moderate-severe PH with 100% sensitivity and high specificity (89%). We conclude that BNP is an excellent marker for the presence of PH in patients with lung fibrosis. In addition, our data suggest that PH contributes significantly to exercise limitation in patients with severe lung fibrosis, raising the possibility that treatment of PH may be beneficial in these patients. |
| doi_str_mv | 10.1164/rccm.200308-1142OC |
| format | Article |
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Noninvasive parameters in the evaluation of PH in lung disease could aid in the management of these subjects. In this study, we aimed to characterize the role of brain natriuretic peptide (BNP) and the six-minute walk distance (6-MWD) in the assessment of pulmonary hypertension (PH) in subjects with lung fibrosis. Subjects with lung fibrosis and elevated BNP levels (n = 20) had significantly more severe PH during right heart catheterization than those with lung fibrosis, and normal BNP levels (mean pulmonary arterial pressure (40.85 +/- 3.2 mm Hg vs. 23.42+/-1.44 mm Hg, respectively) (n = 19) (p < 0.001). Significant correlations between lung volumes and BNP concentrations were not observed. A weak correlation existed between capillary pO(2) and 6-MWD (r = 0.42; p < 0.001). The presence of moderate-severe PH was associated with significant reduction of the 6-MWD. BNP concentrations predicted moderate-severe PH with 100% sensitivity and high specificity (89%). We conclude that BNP is an excellent marker for the presence of PH in patients with lung fibrosis. In addition, our data suggest that PH contributes significantly to exercise limitation in patients with severe lung fibrosis, raising the possibility that treatment of PH may be beneficial in these patients.</description><identifier>ISSN: 1073-449X</identifier><identifier>ISSN: 0003-0805</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.200308-1142OC</identifier><identifier>PMID: 15087298</identifier><language>eng</language><publisher>New York, NY: Am Thoracic Soc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Biomarkers - blood ; Exercise Tolerance ; Female ; Humans ; Hypertension, Pulmonary - blood ; Hypertension, Pulmonary - classification ; Hypertension, Pulmonary - physiopathology ; Intensive care medicine ; Male ; Medical sciences ; Middle Aged ; Natriuretic Peptide, Brain - blood ; Pulmonary Fibrosis - blood ; Pulmonary Fibrosis - complications ; Pulmonary Fibrosis - physiopathology ; Respiratory Function Tests ; Sensitivity and Specificity</subject><ispartof>American journal of respiratory and critical care medicine, 2004-08, Vol.170 (4), p.360-365</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Thoracic Society Aug 15, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-ecc8c5128da3828feeb458650fa5930b1fce5bde0e3a69e6c9d1fa3e82209aae3</citedby><cites>FETCH-LOGICAL-c487t-ecc8c5128da3828feeb458650fa5930b1fce5bde0e3a69e6c9d1fa3e82209aae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4011,4012,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16001111$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15087298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leuchte, Hanno H</creatorcontrib><creatorcontrib>Neurohr, Claus</creatorcontrib><creatorcontrib>Baumgartner, Rainer</creatorcontrib><creatorcontrib>Holzapfel, Michael</creatorcontrib><creatorcontrib>Giehrl, Wolfgang</creatorcontrib><creatorcontrib>Vogeser, Michael</creatorcontrib><creatorcontrib>Behr, Jurgen</creatorcontrib><title>Brain Natriuretic Peptide and Exercise Capacity in Lung Fibrosis and Pulmonary Hypertension</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Pulmonary hypertension (PH) can develop in lung fibrosis, and contributes to increased morbidity and mortality. Noninvasive parameters in the evaluation of PH in lung disease could aid in the management of these subjects. In this study, we aimed to characterize the role of brain natriuretic peptide (BNP) and the six-minute walk distance (6-MWD) in the assessment of pulmonary hypertension (PH) in subjects with lung fibrosis. Subjects with lung fibrosis and elevated BNP levels (n = 20) had significantly more severe PH during right heart catheterization than those with lung fibrosis, and normal BNP levels (mean pulmonary arterial pressure (40.85 +/- 3.2 mm Hg vs. 23.42+/-1.44 mm Hg, respectively) (n = 19) (p < 0.001). Significant correlations between lung volumes and BNP concentrations were not observed. A weak correlation existed between capillary pO(2) and 6-MWD (r = 0.42; p < 0.001). The presence of moderate-severe PH was associated with significant reduction of the 6-MWD. BNP concentrations predicted moderate-severe PH with 100% sensitivity and high specificity (89%). We conclude that BNP is an excellent marker for the presence of PH in patients with lung fibrosis. In addition, our data suggest that PH contributes significantly to exercise limitation in patients with severe lung fibrosis, raising the possibility that treatment of PH may be beneficial in these patients.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Exercise Tolerance</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - blood</subject><subject>Hypertension, Pulmonary - classification</subject><subject>Hypertension, Pulmonary - physiopathology</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Pulmonary Fibrosis - blood</subject><subject>Pulmonary Fibrosis - complications</subject><subject>Pulmonary Fibrosis - physiopathology</subject><subject>Respiratory Function Tests</subject><subject>Sensitivity and Specificity</subject><issn>1073-449X</issn><issn>0003-0805</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkctrFEEQhwdRzEP_AQ8yCAY8TOz346hLYoTF5KAgeGhqemqSXuZl9wy6_729zkLAi33pPnz166r6iuIVJZeUKvE-et9fMkI4MRWlgt1unhSnVHJZCavJ0_wmmldC2O8nxVlKO0IoM5Q8L06oJEYza06LHx8jhKH8AnMMS8Q5-PIOpzk0WMLQlFe_MfqQsNzABD7M-zLD22W4L69DHccU0l_sbun6cYC4L2_2E8YZhxTG4UXxrIUu4cvjfV58u776urmptrefPm8-bCsvjJ4r9N54mVtrgBtmWsRaSKMkaUFaTmraepR1gwQ5KIvK24a2wNEwRiwA8vPiYs2d4vhzwTS7PiSPXQcDjktySmktleT_BanWlBolMvjmH3A3LnHIQzhqrVRMEJshtkI-LyJFbN0UQ5-X4ChxB0HuIMitgtwqKBe9PiYvdY_NY8nRSAbeHgFIHro2wpAFPHIqW8wnc-9W7iHcP_wKEV3qoetyLHWwO_xMNXHCcUX4H6TeqIk</recordid><startdate>20040815</startdate><enddate>20040815</enddate><creator>Leuchte, Hanno H</creator><creator>Neurohr, Claus</creator><creator>Baumgartner, Rainer</creator><creator>Holzapfel, Michael</creator><creator>Giehrl, Wolfgang</creator><creator>Vogeser, Michael</creator><creator>Behr, Jurgen</creator><general>Am Thoracic Soc</general><general>American Lung Association</general><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20040815</creationdate><title>Brain Natriuretic Peptide and Exercise Capacity in Lung Fibrosis and Pulmonary Hypertension</title><author>Leuchte, Hanno H ; Neurohr, Claus ; Baumgartner, Rainer ; Holzapfel, Michael ; Giehrl, Wolfgang ; Vogeser, Michael ; Behr, Jurgen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-ecc8c5128da3828feeb458650fa5930b1fce5bde0e3a69e6c9d1fa3e82209aae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Exercise Tolerance</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - blood</topic><topic>Hypertension, Pulmonary - classification</topic><topic>Hypertension, Pulmonary - physiopathology</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Pulmonary Fibrosis - blood</topic><topic>Pulmonary Fibrosis - complications</topic><topic>Pulmonary Fibrosis - physiopathology</topic><topic>Respiratory Function Tests</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leuchte, Hanno H</creatorcontrib><creatorcontrib>Neurohr, Claus</creatorcontrib><creatorcontrib>Baumgartner, Rainer</creatorcontrib><creatorcontrib>Holzapfel, Michael</creatorcontrib><creatorcontrib>Giehrl, Wolfgang</creatorcontrib><creatorcontrib>Vogeser, Michael</creatorcontrib><creatorcontrib>Behr, Jurgen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leuchte, Hanno H</au><au>Neurohr, Claus</au><au>Baumgartner, Rainer</au><au>Holzapfel, Michael</au><au>Giehrl, Wolfgang</au><au>Vogeser, Michael</au><au>Behr, Jurgen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain Natriuretic Peptide and Exercise Capacity in Lung Fibrosis and Pulmonary Hypertension</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2004-08-15</date><risdate>2004</risdate><volume>170</volume><issue>4</issue><spage>360</spage><epage>365</epage><pages>360-365</pages><issn>1073-449X</issn><issn>0003-0805</issn><eissn>1535-4970</eissn><abstract>Pulmonary hypertension (PH) can develop in lung fibrosis, and contributes to increased morbidity and mortality. Noninvasive parameters in the evaluation of PH in lung disease could aid in the management of these subjects. In this study, we aimed to characterize the role of brain natriuretic peptide (BNP) and the six-minute walk distance (6-MWD) in the assessment of pulmonary hypertension (PH) in subjects with lung fibrosis. Subjects with lung fibrosis and elevated BNP levels (n = 20) had significantly more severe PH during right heart catheterization than those with lung fibrosis, and normal BNP levels (mean pulmonary arterial pressure (40.85 +/- 3.2 mm Hg vs. 23.42+/-1.44 mm Hg, respectively) (n = 19) (p < 0.001). Significant correlations between lung volumes and BNP concentrations were not observed. A weak correlation existed between capillary pO(2) and 6-MWD (r = 0.42; p < 0.001). The presence of moderate-severe PH was associated with significant reduction of the 6-MWD. BNP concentrations predicted moderate-severe PH with 100% sensitivity and high specificity (89%). We conclude that BNP is an excellent marker for the presence of PH in patients with lung fibrosis. In addition, our data suggest that PH contributes significantly to exercise limitation in patients with severe lung fibrosis, raising the possibility that treatment of PH may be beneficial in these patients.</abstract><cop>New York, NY</cop><pub>Am Thoracic Soc</pub><pmid>15087298</pmid><doi>10.1164/rccm.200308-1142OC</doi><tpages>6</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biomarkers - blood Exercise Tolerance Female Humans Hypertension, Pulmonary - blood Hypertension, Pulmonary - classification Hypertension, Pulmonary - physiopathology Intensive care medicine Male Medical sciences Middle Aged Natriuretic Peptide, Brain - blood Pulmonary Fibrosis - blood Pulmonary Fibrosis - complications Pulmonary Fibrosis - physiopathology Respiratory Function Tests Sensitivity and Specificity |
| title | Brain Natriuretic Peptide and Exercise Capacity in Lung Fibrosis and Pulmonary Hypertension |
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