Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA4 gene

Type 1 diabetes (T1D) is a complex autoimmune disease. Several genetic loci have been implicated in the susceptibility to this illness. Evaluated was the role of the CTLA4 exon 1 A49G polymorphism and its role as a risk factor for T1D in our population. DNA from 190 patients with T1D and their famil...

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Veröffentlicht in:	Human immunology 2004-07, Vol.65 (7), p.719-724
Hauptverfasser:	Zalloua, Pierre A., Abchee, Antoine, Shbaklo, Hadia, Zreik, Tony G., Terwedow, Henry, Halaby, Georges, Azar, Sami T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age of Onset Antigens, CD Antigens, Differentiation - genetics Child Child, Preschool CTLA-4 Antigen CTLA4 Data Interpretation, Statistical diabetes Diabetes Mellitus, Type 1 - ethnology Diabetes Mellitus, Type 1 - genetics DNA - genetics DNA - isolation & purification early onset Exons - genetics Female Gene Frequency - genetics Genetic Predisposition to Disease - genetics Genotype Heterozygote HLA-DQ Antigens - genetics HLA-DQ beta-Chains Homozygote Humans Lebanon Male MHC Polymerase Chain Reaction Polymorphism, Single Nucleotide - genetics SNP
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