CHAC1/MGC4504 Is a Novel Proapoptotic Component of the Unfolded Protein Response, Downstream of the ATF4-ATF3-CHOP Cascade

To understand pathways mediating the inflammatory responses of human aortic endothelial cells to oxidized phospholipids, we previously used a combination of genetics and genomics to model a coexpression network encompassing >1000 genes. CHAC1 (cation transport regulator-like protein 1), a novel g...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-01, Vol.182 (1), p.466-476
Hauptverfasser:	Mungrue, Imran N, Pagnon, Joanne, Kohannim, Omid, Gargalovic, Peter S, Lusis, Aldons J
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 3 - chemistry Activating Transcription Factor 3 - genetics Activating Transcription Factor 4 - chemistry Apoptosis Inducing Factor - physiology Apoptosis Regulatory Proteins - chemistry Apoptosis Regulatory Proteins - physiology Dithiothreitol - pharmacology Gene Expression Profiling HeLa Cells Humans Oligonucleotide Array Sequence Analysis Phosphatidylcholines - pharmacology Poly(ADP-ribose) Polymerases - physiology Protein Folding Signal Transduction - drug effects Signal Transduction - immunology Transcription Factor CHOP - chemistry Transcription Factor CHOP - genetics Tunicamycin - pharmacology Vesicular Transport Proteins - biosynthesis Vesicular Transport Proteins - chemistry Vesicular Transport Proteins - genetics Vesicular Transport Proteins - physiology
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