A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects
Objective: The aim of the present study was to examine if absence of a common allele in a microsatellite polymorphism in the insulin-like growth factor I ( IGF-I) promoter was associated with type 2 diabetes and alterations in quantitative traits in glucose-tolerant subjects. Methods: The IGF-I prom...
Gespeichert in:
| Veröffentlicht in: | Clinical biochemistry 2004-08, Vol.37 (8), p.660-665 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 665 |
|---|---|
| container_issue | 8 |
| container_start_page | 660 |
| container_title | Clinical biochemistry |
| container_volume | 37 |
| creator | Nielsen, Eva-Maria D Hansen, Lars Lajer, Maria Andersen, Kirstine L Echwald, Søren M Urhammer, Søren A Hansen, Torben Pedersen, Oluf |
| description | Objective: The aim of the present study was to examine if absence of a common allele in a microsatellite polymorphism in the insulin-like growth factor I (
IGF-I) promoter was associated with type 2 diabetes and alterations in quantitative traits in glucose-tolerant subjects.
Methods: The
IGF-I promoter polymorphism was investigated in a case-control study comprising 694 type 2 diabetic patients and 218 glucose-tolerant control subjects, and in two genotype-quantitative trait studies involving 208 glucose-tolerant first-degree offspring of type 2 diabetic patients and 218 unrelated middle-aged subjects with normal glucose tolerance.
Results: No associations were found between the lack of the common promoter allele and type 2 diabetes (
P = 0.25) or estimates of glucose metabolism in glucose-tolerant subjects. Presence of the wild-type allele was associated with an increase in fasting serum triglyceride levels in the group of 208 glucose-tolerant first-degree offspring of type 2 diabetic patients (
P = 0.002). This finding was replicated in an independent sample of 218 unrelated middle-aged subjects with normal glucose tolerance (
P = 0.007).
Conclusion: The present study provides evidence that the common wild-type allele of the
IGF-I promoter polymorphism is associated with increased levels of fasting serum triglyceride in glucose-tolerant whites. |
| doi_str_mv | 10.1016/j.clinbiochem.2004.03.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66774809</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0009912004000931</els_id><sourcerecordid>66774809</sourcerecordid><originalsourceid>FETCH-LOGICAL-c404t-c7c28d392f5aececb76e39d4dc171f0412dbb4db95eb8cbfbcd1f97bd79bb9be3</originalsourceid><addsrcrecordid>eNqNkcGO0zAQhi0EYsvCKyBz4ZZgO24cH1cVu1RaiQucrXg8aV05cbGdRX2LfWRSWglucBqN9P0zmvkI-cBZzRlvPx1qCH6yPsIex1owJmvW1IzLF2TFO9VUQjfNS7JijOlKc8FuyJucD0srZNe-Jjd83TDRMrUiz3cU4jjGiR5jOI0xHfc-j9RPtOyRHlMcY8FE4_C73z7cV1u6wwlpn3ME3xfM9Kcv-yUBCfuMjg59Ln7a0YxpHmlJfhdOgMk7pAGfMOTz9F2YIWasSgyY-qnQPNsDQslvyauhDxnfXest-X7_-dvmS_X49WG7uXusQDJZKlAgOtdoMax7BASrWmy0kw644gOTXDhrpbN6jbYDO1hwfNDKOqWt1RabW_LxMne58ceMuZjRZ8AQ-gnjnE3bKiU7pv8JcqWYFFosoL6AkGLOCQdzTH7s08lwZs7ezMH85c2cvRnWmMXbkn1_XTLbEd2f5FXUAmwuwPI_fPKYTAaPE6DzaXmbcdH_x5pfPSi0Uw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17704292</pqid></control><display><type>article</type><title>A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Nielsen, Eva-Maria D ; Hansen, Lars ; Lajer, Maria ; Andersen, Kirstine L ; Echwald, Søren M ; Urhammer, Søren A ; Hansen, Torben ; Pedersen, Oluf</creator><creatorcontrib>Nielsen, Eva-Maria D ; Hansen, Lars ; Lajer, Maria ; Andersen, Kirstine L ; Echwald, Søren M ; Urhammer, Søren A ; Hansen, Torben ; Pedersen, Oluf</creatorcontrib><description>Objective: The aim of the present study was to examine if absence of a common allele in a microsatellite polymorphism in the insulin-like growth factor I (
IGF-I) promoter was associated with type 2 diabetes and alterations in quantitative traits in glucose-tolerant subjects.
Methods: The
IGF-I promoter polymorphism was investigated in a case-control study comprising 694 type 2 diabetic patients and 218 glucose-tolerant control subjects, and in two genotype-quantitative trait studies involving 208 glucose-tolerant first-degree offspring of type 2 diabetic patients and 218 unrelated middle-aged subjects with normal glucose tolerance.
Results: No associations were found between the lack of the common promoter allele and type 2 diabetes (
P = 0.25) or estimates of glucose metabolism in glucose-tolerant subjects. Presence of the wild-type allele was associated with an increase in fasting serum triglyceride levels in the group of 208 glucose-tolerant first-degree offspring of type 2 diabetic patients (
P = 0.002). This finding was replicated in an independent sample of 218 unrelated middle-aged subjects with normal glucose tolerance (
P = 0.007).
Conclusion: The present study provides evidence that the common wild-type allele of the
IGF-I promoter polymorphism is associated with increased levels of fasting serum triglyceride in glucose-tolerant whites.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2004.03.014</identifier><identifier>PMID: 15302607</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Alleles ; Case-Control Studies ; Female ; Genetic epidemiology ; Genotype ; Glucose - metabolism ; Humans ; IGF-I ; Insulin-Like Growth Factor I - genetics ; Insulin-Like Growth Factor I - metabolism ; Male ; Microsatellite ; Microsatellite Repeats ; Middle Aged ; Polymorphism, Genetic ; Polymorphisms ; Promoter Regions, Genetic ; Serum triglyceride ; Triglycerides - blood ; Type 2 diabetes</subject><ispartof>Clinical biochemistry, 2004-08, Vol.37 (8), p.660-665</ispartof><rights>2004 The Canadian Society of Clinical Chemists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-c7c28d392f5aececb76e39d4dc171f0412dbb4db95eb8cbfbcd1f97bd79bb9be3</citedby><cites>FETCH-LOGICAL-c404t-c7c28d392f5aececb76e39d4dc171f0412dbb4db95eb8cbfbcd1f97bd79bb9be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009912004000931$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15302607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nielsen, Eva-Maria D</creatorcontrib><creatorcontrib>Hansen, Lars</creatorcontrib><creatorcontrib>Lajer, Maria</creatorcontrib><creatorcontrib>Andersen, Kirstine L</creatorcontrib><creatorcontrib>Echwald, Søren M</creatorcontrib><creatorcontrib>Urhammer, Søren A</creatorcontrib><creatorcontrib>Hansen, Torben</creatorcontrib><creatorcontrib>Pedersen, Oluf</creatorcontrib><title>A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>Objective: The aim of the present study was to examine if absence of a common allele in a microsatellite polymorphism in the insulin-like growth factor I (
IGF-I) promoter was associated with type 2 diabetes and alterations in quantitative traits in glucose-tolerant subjects.
Methods: The
IGF-I promoter polymorphism was investigated in a case-control study comprising 694 type 2 diabetic patients and 218 glucose-tolerant control subjects, and in two genotype-quantitative trait studies involving 208 glucose-tolerant first-degree offspring of type 2 diabetic patients and 218 unrelated middle-aged subjects with normal glucose tolerance.
Results: No associations were found between the lack of the common promoter allele and type 2 diabetes (
P = 0.25) or estimates of glucose metabolism in glucose-tolerant subjects. Presence of the wild-type allele was associated with an increase in fasting serum triglyceride levels in the group of 208 glucose-tolerant first-degree offspring of type 2 diabetic patients (
P = 0.002). This finding was replicated in an independent sample of 218 unrelated middle-aged subjects with normal glucose tolerance (
P = 0.007).
Conclusion: The present study provides evidence that the common wild-type allele of the
IGF-I promoter polymorphism is associated with increased levels of fasting serum triglyceride in glucose-tolerant whites.</description><subject>Aged</subject><subject>Alleles</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Genetic epidemiology</subject><subject>Genotype</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>IGF-I</subject><subject>Insulin-Like Growth Factor I - genetics</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Male</subject><subject>Microsatellite</subject><subject>Microsatellite Repeats</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphisms</subject><subject>Promoter Regions, Genetic</subject><subject>Serum triglyceride</subject><subject>Triglycerides - blood</subject><subject>Type 2 diabetes</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcGO0zAQhi0EYsvCKyBz4ZZgO24cH1cVu1RaiQucrXg8aV05cbGdRX2LfWRSWglucBqN9P0zmvkI-cBZzRlvPx1qCH6yPsIex1owJmvW1IzLF2TFO9VUQjfNS7JijOlKc8FuyJucD0srZNe-Jjd83TDRMrUiz3cU4jjGiR5jOI0xHfc-j9RPtOyRHlMcY8FE4_C73z7cV1u6wwlpn3ME3xfM9Kcv-yUBCfuMjg59Ln7a0YxpHmlJfhdOgMk7pAGfMOTz9F2YIWasSgyY-qnQPNsDQslvyauhDxnfXest-X7_-dvmS_X49WG7uXusQDJZKlAgOtdoMax7BASrWmy0kw644gOTXDhrpbN6jbYDO1hwfNDKOqWt1RabW_LxMne58ceMuZjRZ8AQ-gnjnE3bKiU7pv8JcqWYFFosoL6AkGLOCQdzTH7s08lwZs7ezMH85c2cvRnWmMXbkn1_XTLbEd2f5FXUAmwuwPI_fPKYTAaPE6DzaXmbcdH_x5pfPSi0Uw</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Nielsen, Eva-Maria D</creator><creator>Hansen, Lars</creator><creator>Lajer, Maria</creator><creator>Andersen, Kirstine L</creator><creator>Echwald, Søren M</creator><creator>Urhammer, Søren A</creator><creator>Hansen, Torben</creator><creator>Pedersen, Oluf</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040801</creationdate><title>A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects</title><author>Nielsen, Eva-Maria D ; Hansen, Lars ; Lajer, Maria ; Andersen, Kirstine L ; Echwald, Søren M ; Urhammer, Søren A ; Hansen, Torben ; Pedersen, Oluf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-c7c28d392f5aececb76e39d4dc171f0412dbb4db95eb8cbfbcd1f97bd79bb9be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Alleles</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Genetic epidemiology</topic><topic>Genotype</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>IGF-I</topic><topic>Insulin-Like Growth Factor I - genetics</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Male</topic><topic>Microsatellite</topic><topic>Microsatellite Repeats</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphisms</topic><topic>Promoter Regions, Genetic</topic><topic>Serum triglyceride</topic><topic>Triglycerides - blood</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nielsen, Eva-Maria D</creatorcontrib><creatorcontrib>Hansen, Lars</creatorcontrib><creatorcontrib>Lajer, Maria</creatorcontrib><creatorcontrib>Andersen, Kirstine L</creatorcontrib><creatorcontrib>Echwald, Søren M</creatorcontrib><creatorcontrib>Urhammer, Søren A</creatorcontrib><creatorcontrib>Hansen, Torben</creatorcontrib><creatorcontrib>Pedersen, Oluf</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nielsen, Eva-Maria D</au><au>Hansen, Lars</au><au>Lajer, Maria</au><au>Andersen, Kirstine L</au><au>Echwald, Søren M</au><au>Urhammer, Søren A</au><au>Hansen, Torben</au><au>Pedersen, Oluf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>37</volume><issue>8</issue><spage>660</spage><epage>665</epage><pages>660-665</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>Objective: The aim of the present study was to examine if absence of a common allele in a microsatellite polymorphism in the insulin-like growth factor I (
IGF-I) promoter was associated with type 2 diabetes and alterations in quantitative traits in glucose-tolerant subjects.
Methods: The
IGF-I promoter polymorphism was investigated in a case-control study comprising 694 type 2 diabetic patients and 218 glucose-tolerant control subjects, and in two genotype-quantitative trait studies involving 208 glucose-tolerant first-degree offspring of type 2 diabetic patients and 218 unrelated middle-aged subjects with normal glucose tolerance.
Results: No associations were found between the lack of the common promoter allele and type 2 diabetes (
P = 0.25) or estimates of glucose metabolism in glucose-tolerant subjects. Presence of the wild-type allele was associated with an increase in fasting serum triglyceride levels in the group of 208 glucose-tolerant first-degree offspring of type 2 diabetic patients (
P = 0.002). This finding was replicated in an independent sample of 218 unrelated middle-aged subjects with normal glucose tolerance (
P = 0.007).
Conclusion: The present study provides evidence that the common wild-type allele of the
IGF-I promoter polymorphism is associated with increased levels of fasting serum triglyceride in glucose-tolerant whites.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15302607</pmid><doi>10.1016/j.clinbiochem.2004.03.014</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9120 |
| ispartof | Clinical biochemistry, 2004-08, Vol.37 (8), p.660-665 |
| issn | 0009-9120 1873-2933 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66774809 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Alleles Case-Control Studies Female Genetic epidemiology Genotype Glucose - metabolism Humans IGF-I Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Male Microsatellite Microsatellite Repeats Middle Aged Polymorphism, Genetic Polymorphisms Promoter Regions, Genetic Serum triglyceride Triglycerides - blood Type 2 diabetes |
| title | A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T21%3A14%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20common%20polymorphism%20in%20the%20promoter%20of%20the%20IGF-I%20gene%20associates%20with%20increased%20fasting%20serum%20triglyceride%20levels%20in%20glucose-tolerant%20subjects&rft.jtitle=Clinical%20biochemistry&rft.au=Nielsen,%20Eva-Maria%20D&rft.date=2004-08-01&rft.volume=37&rft.issue=8&rft.spage=660&rft.epage=665&rft.pages=660-665&rft.issn=0009-9120&rft.eissn=1873-2933&rft_id=info:doi/10.1016/j.clinbiochem.2004.03.014&rft_dat=%3Cproquest_cross%3E66774809%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17704292&rft_id=info:pmid/15302607&rft_els_id=S0009912004000931&rfr_iscdi=true |