Ovarian Hormones and Cognition in the Aged Female Rat: II. Progesterone Supplementation Reverses the Cognitive Enhancing Effects of Ovariectomy

The authors hypothesized that the progesterone component of some hormone replacement therapies in women is detrimental to cognition. A previous study showed that ovariectomy (ovx) in aged rats enhanced spatial working memory and decreased elevated progesterone levels ( H. A. Bimonte-Nelson, R. S. Si...

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Veröffentlicht in:	Behavioral neuroscience 2004-08, Vol.118 (4), p.707-714
Hauptverfasser:	Bimonte-Nelson, Heather A, Singleton, Rachel S, Williams, Brice J, Granholm, Ann-Charlotte E
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging - physiology Animal Animals Behavior, Animal Behavioral psychophysiology Biological and medical sciences Cognition Cognition & reasoning Cognition - drug effects Female Females Fundamental and applied biological sciences. Psychology Gonadal Hormones - physiology Hormone replacement therapy Hormone Therapy Hormones Hormones and behavior Learning Learning. Memory Maze Learning - drug effects Memory, Short-Term - drug effects Ovariectomy Ovariectomy - methods Ovaries Progesterone Progesterone - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred F344 Rodents Short Term Memory Spatial Behavior - drug effects Spatial Memory
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