Gallbladder myocytes are short and cholecystokinin-resistant in obese diabetic mice

Obesity is associated with diabetes and gallstone formation. Obese leptin-deficient (Lepob) and leptin-resistant (Lepdb) mice are hyperglycemic and have enlarged gallbladders with diminished response in vitro to cholecystokinin (CCK) and acetylcholine (ACh). Whether this phenomenon is secondary to h...

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Veröffentlicht in:	Surgery 2004-08, Vol.136 (2), p.431-436
Hauptverfasser:	Graewin, Shannon J., Lee, Keun-Ho, Kiely, James M., Svatek, Carol L., Nakeeb, Attila, Pitt, Henry A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Biological and medical sciences Blood Glucose - analysis Body Weight Cholecystokinin - pharmacology Diabetes Mellitus - physiopathology Female Gallbladder - cytology Gallbladder - drug effects General aspects Leptin - deficiency Medical sciences Metabolic diseases Mice Mice, Inbred C57BL Mice, Obese Muscle Contraction - drug effects Myocytes, Smooth Muscle - drug effects Obesity
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