Lack of immunological or molecular evidence for a role of mouse mammary tumor retrovirus in primary biliary cirrhosis

Recent observations, including a pilot clinical trial, have suggested that a human mouse mammary tumor virus (MMTV) causes primary biliary cirrhosis (PBC). We attempted to confirm such data. We obtained sera from 101 patients (53 with PBC and 48 controls), fixed liver sections from 10 patients (8 PB...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2004-08, Vol.127 (2), p.493-501
Hauptverfasser:	Selmi, Carlo, Ross, Susan R, Ansari, Aftab A, Invernizzi, Pietro, Podda, Mauro, Coppel, Ross L, Gershwin, M Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibodies, Viral - blood Antigens, Viral, Tumor - genetics Base Sequence Female Humans Liver - virology Liver Cirrhosis, Biliary - virology Lymphocytes - virology Mammary Tumor Virus, Mouse - genetics Mammary Tumor Virus, Mouse - immunology Mammary Tumor Virus, Mouse - isolation & purification Middle Aged Molecular Sequence Data Retroviridae Infections - complications Retroviridae Infections - diagnosis Retroviridae Infections - immunology Tumor Virus Infections - complications Tumor Virus Infections - diagnosis Tumor Virus Infections - immunology Viral Core Proteins - genetics
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