Subphysiologic Apolipoprotein E (ApoE) Plasma Levels Inhibit Neointimal Formation After Arterial Injury in ApoE-Deficient Mice

OBJECTIVE—Apolipoprotein E (apoE) reduces mouse atherosclerosis progression independent of plasma cholesterol level effects. A mouse artery injury model was used to examine whether apoE exhibits beneficial lipid-independent effects on neointimal formation. METHODS AND RESULTS—ApoE-deficient (apoE−/−...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2004-08, Vol.24 (8), p.1460-1465
Hauptverfasser:	Wientgen, Hilke, Thorngate, Fayanne E, Omerhodzic, Sabina, Rolnitzky, Linda, Fallon, John T, Williams, David L, Fisher, Edward A
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - analysis Actins - deficiency Animals Apolipoproteins E - blood Apolipoproteins E - deficiency Apolipoproteins E - genetics Apolipoproteins E - physiology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cholesterol - blood Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Femoral Artery - injuries Femoral Artery - pathology Foam Cells - pathology Hyperplasia Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Tunica Intima - pathology
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