Effect of vitamin E on carotid artery elasticity and baroreflex gain in young, healthy adults
In this study we tested the hypothesis that dietary vitamin E supplementation can improve carotid artery elasticity and cardio-vagal baroreflex gain in young, healthy individuals. A total of 20 subjects were studied in a double-blind, placebo-controlled, randomized study. Subjects in the active trea...
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| Veröffentlicht in: | Autonomic neuroscience 2004-06, Vol.113 (1), p.63-70 |
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| creator | Studinger, Péter Mersich, Beatrix Lénárd, Zsuzsanna Somogyi, Anikó Kollai, Mark |
| description | In this study we tested the hypothesis that dietary vitamin E supplementation can improve carotid artery elasticity and cardio-vagal baroreflex gain in young, healthy individuals.
A total of 20 subjects were studied in a double-blind, placebo-controlled, randomized study. Subjects in the active treatment group received 700 IU/day vitamin E for 1 month. Each subject was studied three times: before, during and 1 month after treatment. Plasma vitamin E levels were determined using high-performance liquid chromatography. Carotid artery diameter was measured by ultrasound and radial artery pressure by tonometry. Baroreflex function was assessed by time and frequency domain spontaneous indices.
Plasma vitamin E levels increased by 123%, which was associated with a 20% increase in carotid artery compliance and a 30–60% increase in baroreflex indices. All these changes regressed 1 month after cessation of vitamin E supplementation. Significant correlations were observed across conditions (control, treatment and recovery), among plasma vitamin E concentrations, carotid artery compliance and distensibility values and two of the baroreflex gain indices in the treatment group.
Our results demonstrate that vitamin E supplementation can increase carotid artery compliance and baroreflex gain in young, apparently healthy adults. |
| doi_str_mv | 10.1016/j.autneu.2004.05.003 |
| format | Article |
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A total of 20 subjects were studied in a double-blind, placebo-controlled, randomized study. Subjects in the active treatment group received 700 IU/day vitamin E for 1 month. Each subject was studied three times: before, during and 1 month after treatment. Plasma vitamin E levels were determined using high-performance liquid chromatography. Carotid artery diameter was measured by ultrasound and radial artery pressure by tonometry. Baroreflex function was assessed by time and frequency domain spontaneous indices.
Plasma vitamin E levels increased by 123%, which was associated with a 20% increase in carotid artery compliance and a 30–60% increase in baroreflex indices. All these changes regressed 1 month after cessation of vitamin E supplementation. Significant correlations were observed across conditions (control, treatment and recovery), among plasma vitamin E concentrations, carotid artery compliance and distensibility values and two of the baroreflex gain indices in the treatment group.
Our results demonstrate that vitamin E supplementation can increase carotid artery compliance and baroreflex gain in young, apparently healthy adults.</description><identifier>ISSN: 1566-0702</identifier><identifier>EISSN: 1872-7484</identifier><identifier>DOI: 10.1016/j.autneu.2004.05.003</identifier><identifier>PMID: 15296796</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Analysis of Variance ; Baroreflex ; Baroreflex - drug effects ; Baroreflex - physiology ; Biological and medical sciences ; Carotid artery ; Carotid Artery, Common - diagnostic imaging ; Carotid Artery, Common - drug effects ; Carotid Artery, Common - physiology ; Double-Blind Method ; Elasticity - drug effects ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ ; Pilot Projects ; Ultrasonography ; Ultrasound ; Vertebrates: nervous system and sense organs ; Vitamin E ; Vitamin E - pharmacology</subject><ispartof>Autonomic neuroscience, 2004-06, Vol.113 (1), p.63-70</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-dbf6f9e96aae86a123631388c6ebd561ad9a7a54bbbe4a9289110294b72a57a53</citedby><cites>FETCH-LOGICAL-c388t-dbf6f9e96aae86a123631388c6ebd561ad9a7a54bbbe4a9289110294b72a57a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.autneu.2004.05.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16008922$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15296796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Studinger, Péter</creatorcontrib><creatorcontrib>Mersich, Beatrix</creatorcontrib><creatorcontrib>Lénárd, Zsuzsanna</creatorcontrib><creatorcontrib>Somogyi, Anikó</creatorcontrib><creatorcontrib>Kollai, Mark</creatorcontrib><title>Effect of vitamin E on carotid artery elasticity and baroreflex gain in young, healthy adults</title><title>Autonomic neuroscience</title><addtitle>Auton Neurosci</addtitle><description>In this study we tested the hypothesis that dietary vitamin E supplementation can improve carotid artery elasticity and cardio-vagal baroreflex gain in young, healthy individuals.
A total of 20 subjects were studied in a double-blind, placebo-controlled, randomized study. Subjects in the active treatment group received 700 IU/day vitamin E for 1 month. Each subject was studied three times: before, during and 1 month after treatment. Plasma vitamin E levels were determined using high-performance liquid chromatography. Carotid artery diameter was measured by ultrasound and radial artery pressure by tonometry. Baroreflex function was assessed by time and frequency domain spontaneous indices.
Plasma vitamin E levels increased by 123%, which was associated with a 20% increase in carotid artery compliance and a 30–60% increase in baroreflex indices. All these changes regressed 1 month after cessation of vitamin E supplementation. Significant correlations were observed across conditions (control, treatment and recovery), among plasma vitamin E concentrations, carotid artery compliance and distensibility values and two of the baroreflex gain indices in the treatment group.
Our results demonstrate that vitamin E supplementation can increase carotid artery compliance and baroreflex gain in young, apparently healthy adults.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Baroreflex</subject><subject>Baroreflex - drug effects</subject><subject>Baroreflex - physiology</subject><subject>Biological and medical sciences</subject><subject>Carotid artery</subject><subject>Carotid Artery, Common - diagnostic imaging</subject><subject>Carotid Artery, Common - drug effects</subject><subject>Carotid Artery, Common - physiology</subject><subject>Double-Blind Method</subject><subject>Elasticity - drug effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</subject><subject>Pilot Projects</subject><subject>Ultrasonography</subject><subject>Ultrasound</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vitamin E</subject><subject>Vitamin E - pharmacology</subject><issn>1566-0702</issn><issn>1872-7484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFq3DAQhkVpaNK0bxCCLu2pdkayLVuXQAibJhDIJT0WMZbGiRavnUhy6L59tOxCbgWBBPP9M9Inxs4ElAKEuliXuKSJllIC1CU0JUD1iZ2IrpVFW3f153xulCqgBXnMvsa4BoAOtPrCjkUjtWq1OmF_V8NANvF54G8-4cZPfMXniVsMc_KOY0gUtpxGjMlbn7YcJ8f7XA00jPSPP2GO5LWdl-npF38mHNNzptwypviNHQ04Rvp-2E_Zn5vV4_Vtcf_w--766r6wVdelwvWDGjRphUidQiErVYlcsYp61yiBTmOLTd33PdWoZaeFAKnrvpXY5EJ1yn7u-76E-XWhmMzGR0vjiBPNSzRKtS1UWmaw3oM2zDHmJ5iX4DcYtkaA2Wk1a7PXanZaDTQma82x80P_pd-Q-wgdPGbgxwHAaHEcAk7Wxw9OZfVa7uZf7jnKNt48BROtp8mS8yF_g3Gz__9N3gEblZh3</recordid><startdate>20040630</startdate><enddate>20040630</enddate><creator>Studinger, Péter</creator><creator>Mersich, Beatrix</creator><creator>Lénárd, Zsuzsanna</creator><creator>Somogyi, Anikó</creator><creator>Kollai, Mark</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040630</creationdate><title>Effect of vitamin E on carotid artery elasticity and baroreflex gain in young, healthy adults</title><author>Studinger, Péter ; Mersich, Beatrix ; Lénárd, Zsuzsanna ; Somogyi, Anikó ; Kollai, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-dbf6f9e96aae86a123631388c6ebd561ad9a7a54bbbe4a9289110294b72a57a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Baroreflex</topic><topic>Baroreflex - drug effects</topic><topic>Baroreflex - physiology</topic><topic>Biological and medical sciences</topic><topic>Carotid artery</topic><topic>Carotid Artery, Common - diagnostic imaging</topic><topic>Carotid Artery, Common - drug effects</topic><topic>Carotid Artery, Common - physiology</topic><topic>Double-Blind Method</topic><topic>Elasticity - drug effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</topic><topic>Pilot Projects</topic><topic>Ultrasonography</topic><topic>Ultrasound</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Vitamin E</topic><topic>Vitamin E - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Studinger, Péter</creatorcontrib><creatorcontrib>Mersich, Beatrix</creatorcontrib><creatorcontrib>Lénárd, Zsuzsanna</creatorcontrib><creatorcontrib>Somogyi, Anikó</creatorcontrib><creatorcontrib>Kollai, Mark</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Autonomic neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Studinger, Péter</au><au>Mersich, Beatrix</au><au>Lénárd, Zsuzsanna</au><au>Somogyi, Anikó</au><au>Kollai, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of vitamin E on carotid artery elasticity and baroreflex gain in young, healthy adults</atitle><jtitle>Autonomic neuroscience</jtitle><addtitle>Auton Neurosci</addtitle><date>2004-06-30</date><risdate>2004</risdate><volume>113</volume><issue>1</issue><spage>63</spage><epage>70</epage><pages>63-70</pages><issn>1566-0702</issn><eissn>1872-7484</eissn><abstract>In this study we tested the hypothesis that dietary vitamin E supplementation can improve carotid artery elasticity and cardio-vagal baroreflex gain in young, healthy individuals.
A total of 20 subjects were studied in a double-blind, placebo-controlled, randomized study. Subjects in the active treatment group received 700 IU/day vitamin E for 1 month. Each subject was studied three times: before, during and 1 month after treatment. Plasma vitamin E levels were determined using high-performance liquid chromatography. Carotid artery diameter was measured by ultrasound and radial artery pressure by tonometry. Baroreflex function was assessed by time and frequency domain spontaneous indices.
Plasma vitamin E levels increased by 123%, which was associated with a 20% increase in carotid artery compliance and a 30–60% increase in baroreflex indices. All these changes regressed 1 month after cessation of vitamin E supplementation. Significant correlations were observed across conditions (control, treatment and recovery), among plasma vitamin E concentrations, carotid artery compliance and distensibility values and two of the baroreflex gain indices in the treatment group.
Our results demonstrate that vitamin E supplementation can increase carotid artery compliance and baroreflex gain in young, apparently healthy adults.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15296796</pmid><doi>10.1016/j.autneu.2004.05.003</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Analysis of Variance Baroreflex Baroreflex - drug effects Baroreflex - physiology Biological and medical sciences Carotid artery Carotid Artery, Common - diagnostic imaging Carotid Artery, Common - drug effects Carotid Artery, Common - physiology Double-Blind Method Elasticity - drug effects Female Fundamental and applied biological sciences. Psychology Humans Male Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Pilot Projects Ultrasonography Ultrasound Vertebrates: nervous system and sense organs Vitamin E Vitamin E - pharmacology |
| title | Effect of vitamin E on carotid artery elasticity and baroreflex gain in young, healthy adults |
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