Stimulation of renin release by prostaglandin E2 is mediated by EP2 and EP4 receptors in mouse kidneys

PGE(2) is a potent stimulator of renin release. So far, the contribution of each of the four PGE(2) receptor subtypes (EP(1)-EP(4)) in the regulation of renin release has not been characterized. Therefore, we investigated the effects PGE(2) on renin secretion rates (RSR) from isolated, perfused kidn...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2004-09, Vol.287 (3), p.F427-F433
Hauptverfasser:	Schweda, Frank, Klar, Jürgen, Narumiya, Shuh, Nüsing, Rolf M, Kurtz, Armin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dinoprostone - pharmacology In Vitro Techniques Juxtaglomerular Apparatus - metabolism Kidney - blood supply Kidney - drug effects Kidney - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Receptors, Prostaglandin E - genetics Receptors, Prostaglandin E - metabolism Receptors, Prostaglandin E, EP1 Subtype Receptors, Prostaglandin E, EP2 Subtype Receptors, Prostaglandin E, EP3 Subtype Receptors, Prostaglandin E, EP4 Subtype Renal Circulation Renin - metabolism Vascular Resistance
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