Chloroquine–astemizole hybrids with potent in vitro and in vivo antiplasmodial activity

A series of novel hybrids of CQ and astemizole have been shown to possess potent in vitro and in vivo antiplasmodial activity. A dual activity, conjugated approach has been taken to form hybrid molecules of two known antimalarial drugs, chloroquine (CQ) and the non-sedating H1 antagonist astemizole....

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