Discovery of α-amidosulfones as potent and selective agonists of CB2 : Synthesis, SAR, and pharmacokinetic properties
A series of alpha-amidosulfones were found to be potent and selective agonists of CB(2). The discovery, synthesis, and structure-activity relationships of this series of agonists are reported. In addition, the pharmacokinetic properties of the most promising compounds are profiled.
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2009, Vol.19 (1), p.31-35 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 19 |
| creator | MARX, Isaac E DIMAURO, Erin F MARTIN, Matthew W WHITE, Ryan D FREMEAU, Robert T PATEL, Vinod F CHENG, Alan EMKEY, Renee HITCHCOCK, Stephen A LIYUE HUANG HUANG, Ming Y HUMAN, Jason LEE, Josie H XINGWEN LI |
| description | A series of alpha-amidosulfones were found to be potent and selective agonists of CB(2). The discovery, synthesis, and structure-activity relationships of this series of agonists are reported. In addition, the pharmacokinetic properties of the most promising compounds are profiled. |
| doi_str_mv | 10.1016/j.bmcl.2008.11.026 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2009, Vol.19 (1), p.31-35 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66770045 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amides - chemistry Amides - pharmacology Animals Biological and medical sciences Humans Medical sciences Microsomes, Liver Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacokinetics Pharmacology. Drug treatments Rats Receptor, Cannabinoid, CB2 - agonists Structure-Activity Relationship Sulfones - chemistry Sulfones - pharmacology |
| title | Discovery of α-amidosulfones as potent and selective agonists of CB2 : Synthesis, SAR, and pharmacokinetic properties |
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