Target Organ Status in White-Coat Hypertensives: Usefulness of Serum Procollagen Type I Propeptide in the Respect of Left Ventricular Diastolic Dysfunction
Background Myocardial fibrosis is a feature of diastolic dysfunction and target organ damage, which was compared among subjects with normotension (NT), white-coat hypertension (WCH) and essential hypertension (EH). Serum procollagen type I propeptide (PIP) level was assessed as a marker of diastolic...
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| Veröffentlicht in: | Circulation Journal 2009, Vol.73(1), pp.100-105 |
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| creator | Ihm, Sang-Hyun Youn, Ho-Joong Park, Chan-Seok Kim, Hee-Yeol Chang, Kiyuk Seung, Ki-Bae Kim, Jae-Hyung Choi, Kyu-Bo |
| description | Background Myocardial fibrosis is a feature of diastolic dysfunction and target organ damage, which was compared among subjects with normotension (NT), white-coat hypertension (WCH) and essential hypertension (EH). Serum procollagen type I propeptide (PIP) level was assessed as a marker of diastolic dysfunction in WCH. Methods and Results Of 90 subjects, 30 had NT and 30 had WCH (ambulatory daytime blood pressure |
| doi_str_mv | 10.1253/circj.CJ-08-0464 |
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Serum procollagen type I propeptide (PIP) level was assessed as a marker of diastolic dysfunction in WCH. Methods and Results Of 90 subjects, 30 had NT and 30 had WCH (ambulatory daytime blood pressure <135/85 mmHg) and 30 had EH (untreated mild to moderate hypertension); all underwent biochemical and echocardiographic examinations. Those with WCH had a lower left ventricular (LV) mass index than those with EH, but it was higher than in the NT group. WCH patients had a lower mitral valve E/A ratio and a higher LV E/E' (E': septal mitral annular peak velocity) ratio than NT patients, whereas these values were higher and lower respectively than in the EH group. The LV E/E' ratio, an estimate of LV diastolic function, correlated with the serum PIP concentration in WCH patients (r=0.39, P=0.03). Conclusion WCH is an intermediate group between NT and EH in respect of target organ damage. These results show a relationship between LV diastolic function and serum PIP in WCH, so the serum PIP level may be a useful marker of diastolic dysfunction and target organ damage in such patients. (Circ J 2009; 73: 100 - 105)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-08-0464</identifier><identifier>PMID: 19023153</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Adult ; Biomarkers - blood ; Blood Pressure - physiology ; Cardiomyopathies - blood ; Cardiomyopathies - diagnosis ; Cardiomyopathies - physiopathology ; Collagen Type I - blood ; Diastole ; Echocardiography ; Echocardiography, Doppler, Pulsed ; Female ; Fibrosis ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - physiopathology ; Humans ; Hypertension ; Hypertension - blood ; Hypertension - complications ; Hypertension - physiopathology ; Hypertrophy, Left Ventricular - blood ; Hypertrophy, Left Ventricular - diagnosis ; Hypertrophy, Left Ventricular - physiopathology ; Male ; Middle Aged ; Myocardial fibrosis ; Office Visits ; Procollagen ; Ventricular Dysfunction, Left - blood ; Ventricular Dysfunction, Left - diagnosis ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>Circulation Journal, 2009, Vol.73(1), pp.100-105</ispartof><rights>2009 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-545daa672bb415b46305499945145cfc89050389fee47e99896f0c853b3e13453</citedby><cites>FETCH-LOGICAL-c468t-545daa672bb415b46305499945145cfc89050389fee47e99896f0c853b3e13453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19023153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ihm, Sang-Hyun</creatorcontrib><creatorcontrib>Youn, Ho-Joong</creatorcontrib><creatorcontrib>Park, Chan-Seok</creatorcontrib><creatorcontrib>Kim, Hee-Yeol</creatorcontrib><creatorcontrib>Chang, Kiyuk</creatorcontrib><creatorcontrib>Seung, Ki-Bae</creatorcontrib><creatorcontrib>Kim, Jae-Hyung</creatorcontrib><creatorcontrib>Choi, Kyu-Bo</creatorcontrib><title>Target Organ Status in White-Coat Hypertensives: Usefulness of Serum Procollagen Type I Propeptide in the Respect of Left Ventricular Diastolic Dysfunction</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background Myocardial fibrosis is a feature of diastolic dysfunction and target organ damage, which was compared among subjects with normotension (NT), white-coat hypertension (WCH) and essential hypertension (EH). Serum procollagen type I propeptide (PIP) level was assessed as a marker of diastolic dysfunction in WCH. Methods and Results Of 90 subjects, 30 had NT and 30 had WCH (ambulatory daytime blood pressure <135/85 mmHg) and 30 had EH (untreated mild to moderate hypertension); all underwent biochemical and echocardiographic examinations. Those with WCH had a lower left ventricular (LV) mass index than those with EH, but it was higher than in the NT group. WCH patients had a lower mitral valve E/A ratio and a higher LV E/E' (E': septal mitral annular peak velocity) ratio than NT patients, whereas these values were higher and lower respectively than in the EH group. The LV E/E' ratio, an estimate of LV diastolic function, correlated with the serum PIP concentration in WCH patients (r=0.39, P=0.03). Conclusion WCH is an intermediate group between NT and EH in respect of target organ damage. These results show a relationship between LV diastolic function and serum PIP in WCH, so the serum PIP level may be a useful marker of diastolic dysfunction and target organ damage in such patients. (Circ J 2009; 73: 100 - 105)</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Blood Pressure - physiology</subject><subject>Cardiomyopathies - blood</subject><subject>Cardiomyopathies - diagnosis</subject><subject>Cardiomyopathies - physiopathology</subject><subject>Collagen Type I - blood</subject><subject>Diastole</subject><subject>Echocardiography</subject><subject>Echocardiography, Doppler, Pulsed</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - blood</subject><subject>Hypertension - complications</subject><subject>Hypertension - physiopathology</subject><subject>Hypertrophy, Left Ventricular - blood</subject><subject>Hypertrophy, Left Ventricular - diagnosis</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial fibrosis</subject><subject>Office Visits</subject><subject>Procollagen</subject><subject>Ventricular Dysfunction, Left - blood</subject><subject>Ventricular Dysfunction, Left - diagnosis</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9PwjAUxxujEUTvnsxO3gbt-mPt0SwiGhIOYjw2XXmDkbFh25nw3ztgkct77_D5fvPyQeiR4DFJOJ3Y0tntOPuIsYwxE-wKDQllacxkgq9Pt4iVZHSA7rzfYpwozNUtGhCFE0o4HaLJ0rg1hGjh1qaOPoMJrY_KOvrelAHirDEhmh324ALUvvwFf49uClN5eOj3CH1NX5fZLJ4v3t6zl3lsmZAh5oyvjBFpkueM8JwJijlTSjFOGLeFld0jmEpVALAUlJJKFNhKTnMK3decjtDzuXfvmp8WfNC70luoKlND03otRCqU4kkH4jNoXeO9g0LvXbkz7qAJ1kdJ-iRJZx8aS32U1EWe-u4238HqEuitdMD0DGx9MGv4B4wLpa2gb0ypJsdxab4AG-M01PQPrht6sQ</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Ihm, Sang-Hyun</creator><creator>Youn, Ho-Joong</creator><creator>Park, Chan-Seok</creator><creator>Kim, Hee-Yeol</creator><creator>Chang, Kiyuk</creator><creator>Seung, Ki-Bae</creator><creator>Kim, Jae-Hyung</creator><creator>Choi, Kyu-Bo</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2009</creationdate><title>Target Organ Status in White-Coat Hypertensives</title><author>Ihm, Sang-Hyun ; Youn, Ho-Joong ; Park, Chan-Seok ; Kim, Hee-Yeol ; Chang, Kiyuk ; Seung, Ki-Bae ; Kim, Jae-Hyung ; Choi, Kyu-Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-545daa672bb415b46305499945145cfc89050389fee47e99896f0c853b3e13453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Blood Pressure - physiology</topic><topic>Cardiomyopathies - blood</topic><topic>Cardiomyopathies - diagnosis</topic><topic>Cardiomyopathies - physiopathology</topic><topic>Collagen Type I - blood</topic><topic>Diastole</topic><topic>Echocardiography</topic><topic>Echocardiography, Doppler, Pulsed</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - blood</topic><topic>Hypertension - complications</topic><topic>Hypertension - physiopathology</topic><topic>Hypertrophy, Left Ventricular - blood</topic><topic>Hypertrophy, Left Ventricular - diagnosis</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial fibrosis</topic><topic>Office Visits</topic><topic>Procollagen</topic><topic>Ventricular Dysfunction, Left - blood</topic><topic>Ventricular Dysfunction, Left - diagnosis</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ihm, Sang-Hyun</creatorcontrib><creatorcontrib>Youn, Ho-Joong</creatorcontrib><creatorcontrib>Park, Chan-Seok</creatorcontrib><creatorcontrib>Kim, Hee-Yeol</creatorcontrib><creatorcontrib>Chang, Kiyuk</creatorcontrib><creatorcontrib>Seung, Ki-Bae</creatorcontrib><creatorcontrib>Kim, Jae-Hyung</creatorcontrib><creatorcontrib>Choi, Kyu-Bo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ihm, Sang-Hyun</au><au>Youn, Ho-Joong</au><au>Park, Chan-Seok</au><au>Kim, Hee-Yeol</au><au>Chang, Kiyuk</au><au>Seung, Ki-Bae</au><au>Kim, Jae-Hyung</au><au>Choi, Kyu-Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Target Organ Status in White-Coat Hypertensives: Usefulness of Serum Procollagen Type I Propeptide in the Respect of Left Ventricular Diastolic Dysfunction</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2009</date><risdate>2009</risdate><volume>73</volume><issue>1</issue><spage>100</spage><epage>105</epage><pages>100-105</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background Myocardial fibrosis is a feature of diastolic dysfunction and target organ damage, which was compared among subjects with normotension (NT), white-coat hypertension (WCH) and essential hypertension (EH). Serum procollagen type I propeptide (PIP) level was assessed as a marker of diastolic dysfunction in WCH. Methods and Results Of 90 subjects, 30 had NT and 30 had WCH (ambulatory daytime blood pressure <135/85 mmHg) and 30 had EH (untreated mild to moderate hypertension); all underwent biochemical and echocardiographic examinations. Those with WCH had a lower left ventricular (LV) mass index than those with EH, but it was higher than in the NT group. WCH patients had a lower mitral valve E/A ratio and a higher LV E/E' (E': septal mitral annular peak velocity) ratio than NT patients, whereas these values were higher and lower respectively than in the EH group. The LV E/E' ratio, an estimate of LV diastolic function, correlated with the serum PIP concentration in WCH patients (r=0.39, P=0.03). Conclusion WCH is an intermediate group between NT and EH in respect of target organ damage. These results show a relationship between LV diastolic function and serum PIP in WCH, so the serum PIP level may be a useful marker of diastolic dysfunction and target organ damage in such patients. (Circ J 2009; 73: 100 - 105)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>19023153</pmid><doi>10.1253/circj.CJ-08-0464</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biomarkers - blood Blood Pressure - physiology Cardiomyopathies - blood Cardiomyopathies - diagnosis Cardiomyopathies - physiopathology Collagen Type I - blood Diastole Echocardiography Echocardiography, Doppler, Pulsed Female Fibrosis Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans Hypertension Hypertension - blood Hypertension - complications Hypertension - physiopathology Hypertrophy, Left Ventricular - blood Hypertrophy, Left Ventricular - diagnosis Hypertrophy, Left Ventricular - physiopathology Male Middle Aged Myocardial fibrosis Office Visits Procollagen Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - diagnosis Ventricular Dysfunction, Left - physiopathology |
| title | Target Organ Status in White-Coat Hypertensives: Usefulness of Serum Procollagen Type I Propeptide in the Respect of Left Ventricular Diastolic Dysfunction |
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