Sol–gel synthesis and characterization of macroporous calcium phosphate bioceramics containing microporosity
Amorphous calcium phosphate powders were precipitated from calcium metal and phosphoric acid in ethanol. Depending on the quantity of reagent, the CaP powders had different chemical compositions and, after heating, formed beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA) or BCP mixtures. Dilato...
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| Veröffentlicht in: | Acta biomaterialia 2009-02, Vol.5 (2), p.735-742 |
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| container_title | Acta biomaterialia |
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| creator | Fellah, Borhane H. Layrolle, Pierre |
| description | Amorphous calcium phosphate powders were precipitated from calcium metal and phosphoric acid in ethanol. Depending on the quantity of reagent, the CaP powders had different chemical compositions and, after heating, formed beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA) or BCP mixtures. Dilatometric measurements indicated that shrinkage of compacted CaP powders occurred first at around 650°C and continued up to 1200°C. The amorphous CaP powders were mixed with urea beads, compacted under isostatic pressure at 140MPa and sintered at 1100°C for 5h. Scanning electron microscopy indicated that macro–microporous ceramics were produced. The ceramics had spherical macropores of 700–1200μm in diameter, with limited interconnections and a macroporosity of 42% as determined by microcomputed tomography. The micropores ranged from 0.1 to 1μm in diameter. These ceramics made of HA, β-TCP or BCP exhibiting both macroporosity and microporosity can be used as bone fillers. |
| doi_str_mv | 10.1016/j.actbio.2008.09.005 |
| format | Article |
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Depending on the quantity of reagent, the CaP powders had different chemical compositions and, after heating, formed beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA) or BCP mixtures. Dilatometric measurements indicated that shrinkage of compacted CaP powders occurred first at around 650°C and continued up to 1200°C. The amorphous CaP powders were mixed with urea beads, compacted under isostatic pressure at 140MPa and sintered at 1100°C for 5h. Scanning electron microscopy indicated that macro–microporous ceramics were produced. The ceramics had spherical macropores of 700–1200μm in diameter, with limited interconnections and a macroporosity of 42% as determined by microcomputed tomography. The micropores ranged from 0.1 to 1μm in diameter. 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Depending on the quantity of reagent, the CaP powders had different chemical compositions and, after heating, formed beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA) or BCP mixtures. Dilatometric measurements indicated that shrinkage of compacted CaP powders occurred first at around 650°C and continued up to 1200°C. The amorphous CaP powders were mixed with urea beads, compacted under isostatic pressure at 140MPa and sintered at 1100°C for 5h. Scanning electron microscopy indicated that macro–microporous ceramics were produced. The ceramics had spherical macropores of 700–1200μm in diameter, with limited interconnections and a macroporosity of 42% as determined by microcomputed tomography. The micropores ranged from 0.1 to 1μm in diameter. These ceramics made of HA, β-TCP or BCP exhibiting both macroporosity and microporosity can be used as bone fillers.</description><subject>Amorphous powders</subject><subject>Calcium phosphate</subject><subject>Calcium Phosphates - chemistry</subject><subject>Ceramics</subject><subject>Gels</subject><subject>Microscopy, Electron, Scanning</subject><subject>Powders</subject><subject>Sintering</subject><subject>Sol–gel processing</subject><subject>Tomography, X-Ray Computed</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-O1SAUxonROOPoGxjDyl0rFFroxsRM5o_JJC7UNTmlp3O5aaEC1-S68h3mDX0SmfQm7pwVcPh953zwEfKWs5oz3n3Y12Dz4ELdMKZr1teMtc_IOddKV6rt9POyV7KpFOv4GXmV0p4xoXmjX5IzrnXLe8HPif8a5j-_H-5xpuno8w6TSxT8SO0OYhmA0f2C7IKnYaIL2BjWEMMhUQuzdYeFrruQ1h1kpMWLxQiLs-U2-AzOO39Py3kTJZePr8mLCeaEb07rBfl-ffXt8ra6-3Lz-fLTXWWl1rnqlbbNwMQg5TBpJYQepgGBj5PqeNuLAQVObaPtxJmQwDhYyZVCwQEkltoFeb_1XWP4ccCUzeKSxXkGj8W96TrV9VqqJ0HR9EIrJp8EG9ZIUUwUUG5geXZKESezRrdAPBrOzGNyZm-25Mxjcob1piRXZO9O_Q_DguM_0SmqAnzcACz_9tNhNMk69BZHF9FmMwb3_wl_AR_3r6I</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Fellah, Borhane H.</creator><creator>Layrolle, Pierre</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>Sol–gel synthesis and characterization of macroporous calcium phosphate bioceramics containing microporosity</title><author>Fellah, Borhane H. ; Layrolle, Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-978c2b03b44bf87338bfbea1df761593be3ef528cf1034a01ac4177e31aa4e103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Amorphous powders</topic><topic>Calcium phosphate</topic><topic>Calcium Phosphates - chemistry</topic><topic>Ceramics</topic><topic>Gels</topic><topic>Microscopy, Electron, Scanning</topic><topic>Powders</topic><topic>Sintering</topic><topic>Sol–gel processing</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fellah, Borhane H.</creatorcontrib><creatorcontrib>Layrolle, Pierre</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fellah, Borhane H.</au><au>Layrolle, Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sol–gel synthesis and characterization of macroporous calcium phosphate bioceramics containing microporosity</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>5</volume><issue>2</issue><spage>735</spage><epage>742</epage><pages>735-742</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>Amorphous calcium phosphate powders were precipitated from calcium metal and phosphoric acid in ethanol. Depending on the quantity of reagent, the CaP powders had different chemical compositions and, after heating, formed beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA) or BCP mixtures. Dilatometric measurements indicated that shrinkage of compacted CaP powders occurred first at around 650°C and continued up to 1200°C. The amorphous CaP powders were mixed with urea beads, compacted under isostatic pressure at 140MPa and sintered at 1100°C for 5h. Scanning electron microscopy indicated that macro–microporous ceramics were produced. The ceramics had spherical macropores of 700–1200μm in diameter, with limited interconnections and a macroporosity of 42% as determined by microcomputed tomography. The micropores ranged from 0.1 to 1μm in diameter. These ceramics made of HA, β-TCP or BCP exhibiting both macroporosity and microporosity can be used as bone fillers.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>18851931</pmid><doi>10.1016/j.actbio.2008.09.005</doi><tpages>8</tpages></addata></record> |
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| issn | 1742-7061 1878-7568 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amorphous powders Calcium phosphate Calcium Phosphates - chemistry Ceramics Gels Microscopy, Electron, Scanning Powders Sintering Sol–gel processing Tomography, X-Ray Computed |
| title | Sol–gel synthesis and characterization of macroporous calcium phosphate bioceramics containing microporosity |
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