Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

Abstract Autophagy is a catabolic process involved in cell death and in cell protective mechanism. Autophagic cell death is differentiated from apoptosis by the presence of double or multiple-membrane enclosed vesicles, and the ATG proteins are essential for the formation of these autophagic vesicle...

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Veröffentlicht in:	Cancer letters 2009-02, Vol.274 (1), p.95-100
Hauptverfasser:	Cho, Dong-Hyung, Jo, Yoon Kyung, Hwang, Jung Jin, Lee, Yoo Mee, Roh, Seon Ae, Kim, Jin Cheon
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - physiology Apoptosis Regulatory Proteins - metabolism ATG6/Beclin-1 Autophagy Beclin-1 Blotting, Western Caspase Caspase 3 - metabolism Cell death Enzyme Inhibitors - pharmacology Glycerol HeLa Cells Hematology, Oncology and Palliative Medicine Humans Kinases Ligands Membrane Proteins - metabolism Proteins RNA, Small Interfering - pharmacology TNF-Related Apoptosis-Inducing Ligand - metabolism TRAIL Transfection
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