CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity

The CTLA-4 pathway is recognized as a major immune inhibitory axis and is a key therapeutic target for augmenting antitumor immunity or curbing autoimmunity. CTLA-4-deficient mice provide the archetypal example of dysregulated immune homeostasis, developing lethal lymphoproliferation with multiorgan...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-01, Vol.182 (1), p.274-282
Hauptverfasser:	Schmidt, Emily M, Wang, Chun Jing, Ryan, Gemma A, Clough, Louise E, Qureshi, Omar S, Goodall, Margaret, Abbas, Abul K, Sharpe, Arlene H, Sansom, David M, Walker, Lucy S. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Antigens, CD - metabolism Antigens, CD - physiology Autoimmune Diseases - genetics Autoimmune Diseases - pathology Autoimmune Diseases - prevention & control Cell Differentiation - genetics Cell Differentiation - immunology Cell Proliferation CTLA-4 Antigen Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Forkhead Transcription Factors - biosynthesis Forkhead Transcription Factors - genetics Homeostasis - genetics Homeostasis - immunology Immunosuppressive Agents - metabolism Islets of Langerhans - immunology Islets of Langerhans - metabolism Islets of Langerhans - pathology Lymphoproliferative Disorders - genetics Lymphoproliferative Disorders - immunology Lymphoproliferative Disorders - mortality Mice Mice, Inbred BALB C Mice, Knockout Mice, Transgenic Receptors, Antigen, T-Cell - biosynthesis Receptors, Antigen, T-Cell - genetics Signal Transduction - genetics Signal Transduction - immunology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology
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