Post-exercise facilitation and depression of motor evoked potentials to transcranial magnetic stimulation: a study in multiple sclerosis

Objective: To evaluate motor cortex excitability changes by transcranial magnetic stimulation (TMS) following repetitive muscle contractions in patients with multiple sclerosis (MS); to state whether a typical pattern of post-exercise motor evoked potentials (MEPs) is related to clinical fatigue in...

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Veröffentlicht in:Clinical neurophysiology 2004-09, Vol.115 (9), p.2128-2133
Hauptverfasser: Perretti, A, Balbi, P, Orefice, G, Trojano, L, Marcantonio, L, Brescia-Morra, V, Ascione, S, Manganelli, F, Conte, G, Santoro, L
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container_end_page 2133
container_issue 9
container_start_page 2128
container_title Clinical neurophysiology
container_volume 115
creator Perretti, A
Balbi, P
Orefice, G
Trojano, L
Marcantonio, L
Brescia-Morra, V
Ascione, S
Manganelli, F
Conte, G
Santoro, L
description Objective: To evaluate motor cortex excitability changes by transcranial magnetic stimulation (TMS) following repetitive muscle contractions in patients with multiple sclerosis (MS); to state whether a typical pattern of post-exercise motor evoked potentials (MEPs) is related to clinical fatigue in MS. Methods: In 41 patients with definite MS (32 with fatigue and 9 without fatigue according to Fatigue Severity Scale) and 13 controls, MEPs were recorded at rest: at baseline condition, following repetitive contractions until fatigue, and after fatigue, to evaluate post-exercise MEP facilitation (PEF) and depression (PED). Results: After exercise, MEP amplitude significantly increased both in patients and controls (PEF). When fatigue set in, MEP amplitude was significantly reduced in normal subjects (PED), but not in patients. Post-exercise MEP findings were similar both in patients with and without fatigue. Conclusions: Our findings suggest an intracortical motor dysfunction following a voluntary contraction in MS patients, possibly due to failure of depression of facilitatory cortical circuits, or alternatively of inhibitory mechanisms.
doi_str_mv 10.1016/j.clinph.2004.03.028
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Methods: In 41 patients with definite MS (32 with fatigue and 9 without fatigue according to Fatigue Severity Scale) and 13 controls, MEPs were recorded at rest: at baseline condition, following repetitive contractions until fatigue, and after fatigue, to evaluate post-exercise MEP facilitation (PEF) and depression (PED). Results: After exercise, MEP amplitude significantly increased both in patients and controls (PEF). When fatigue set in, MEP amplitude was significantly reduced in normal subjects (PED), but not in patients. Post-exercise MEP findings were similar both in patients with and without fatigue. Conclusions: Our findings suggest an intracortical motor dysfunction following a voluntary contraction in MS patients, possibly due to failure of depression of facilitatory cortical circuits, or alternatively of inhibitory mechanisms.</description><identifier>ISSN: 1388-2457</identifier><identifier>EISSN: 1872-8952</identifier><identifier>DOI: 10.1016/j.clinph.2004.03.028</identifier><identifier>PMID: 15294215</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Biological and medical sciences ; Depression ; Electric Stimulation ; Electrodiagnosis. Electric activity recording ; Evoked Potentials, Motor - physiology ; Exercise ; Facilitation ; Fatigue ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic stimulation ; Male ; Medical sciences ; Middle Aged ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Motor Neurons - physiology ; Multiple sclerosis ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. 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Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Motor Neurons - physiology</subject><subject>Multiple sclerosis</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Multiple Sclerosis, Relapsing-Remitting - physiopathology</subject><subject>Muscle Fatigue - physiology</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - physiology</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Post-exercise facilitation</subject><subject>Transcranial Magnetic Stimulation</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>1388-2457</issn><issn>1872-8952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcuKFDEUDaI4Y-sfiGSjuyrzqKcLYRh8wYAudB3SyY2mTSVlbmpw_sDPNm03zE4Cyb2Xcw8n5xDynLOWMz68PrQm-Lj-aAVjXctky8T0gFzyaRTNNPfiYa3lNDWi68cL8gTxwBgbWScekwvei7kTvL8kf74kLA38hmw8AnXa-OCLLj5FqqOlFtYMiMc2ObqkkjKF2_QTLF1TgVi8DkhLoiXriKZedUAX_T1C8YZi8csW_tG9obq2m72jPtI6LH4NQNEEyAk9PiWPXKWCZ-d3R769f_f1-mNz8_nDp-urm8bUz5RGgOFWDmxyGkY9M9kLZ_h-1mZ2HcxW6o53fT2WjYLvu1G4uQdpwUmpB8fljrw68a45_doAi1o8GghBR0gbqmEYh2kQsgK7E9BUfZjBqTX7Rec7xZk6JqAO6pSAOiagmFQ1gbr24sy_7Rew90tnyyvg5Rmg0ejgqmXV-nvcwCRnVcCOvD3hoLpx6yErNB6iAeszmKJs8v9X8hfeWKoU</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Perretti, A</creator><creator>Balbi, P</creator><creator>Orefice, G</creator><creator>Trojano, L</creator><creator>Marcantonio, L</creator><creator>Brescia-Morra, V</creator><creator>Ascione, S</creator><creator>Manganelli, F</creator><creator>Conte, G</creator><creator>Santoro, L</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Post-exercise facilitation and depression of motor evoked potentials to transcranial magnetic stimulation: a study in multiple sclerosis</title><author>Perretti, A ; Balbi, P ; Orefice, G ; Trojano, L ; Marcantonio, L ; Brescia-Morra, V ; Ascione, S ; Manganelli, F ; Conte, G ; Santoro, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-2ec1d3608fae7a90352fc1b9ac9f4e9d3a4145454d0721b472f95e3def33a6f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Depression</topic><topic>Electric Stimulation</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Evoked Potentials, Motor - physiology</topic><topic>Exercise</topic><topic>Facilitation</topic><topic>Fatigue</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic stimulation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Motor Neurons - physiology</topic><topic>Multiple sclerosis</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Multiple Sclerosis, Relapsing-Remitting - physiopathology</topic><topic>Muscle Fatigue - physiology</topic><topic>Muscle, Skeletal - innervation</topic><topic>Muscle, Skeletal - physiology</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Post-exercise facilitation</topic><topic>Transcranial Magnetic Stimulation</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perretti, A</creatorcontrib><creatorcontrib>Balbi, P</creatorcontrib><creatorcontrib>Orefice, G</creatorcontrib><creatorcontrib>Trojano, L</creatorcontrib><creatorcontrib>Marcantonio, L</creatorcontrib><creatorcontrib>Brescia-Morra, V</creatorcontrib><creatorcontrib>Ascione, S</creatorcontrib><creatorcontrib>Manganelli, F</creatorcontrib><creatorcontrib>Conte, G</creatorcontrib><creatorcontrib>Santoro, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perretti, A</au><au>Balbi, P</au><au>Orefice, G</au><au>Trojano, L</au><au>Marcantonio, L</au><au>Brescia-Morra, V</au><au>Ascione, S</au><au>Manganelli, F</au><au>Conte, G</au><au>Santoro, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-exercise facilitation and depression of motor evoked potentials to transcranial magnetic stimulation: a study in multiple sclerosis</atitle><jtitle>Clinical neurophysiology</jtitle><addtitle>Clin Neurophysiol</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>115</volume><issue>9</issue><spage>2128</spage><epage>2133</epage><pages>2128-2133</pages><issn>1388-2457</issn><eissn>1872-8952</eissn><abstract>Objective: To evaluate motor cortex excitability changes by transcranial magnetic stimulation (TMS) following repetitive muscle contractions in patients with multiple sclerosis (MS); to state whether a typical pattern of post-exercise motor evoked potentials (MEPs) is related to clinical fatigue in MS. Methods: In 41 patients with definite MS (32 with fatigue and 9 without fatigue according to Fatigue Severity Scale) and 13 controls, MEPs were recorded at rest: at baseline condition, following repetitive contractions until fatigue, and after fatigue, to evaluate post-exercise MEP facilitation (PEF) and depression (PED). Results: After exercise, MEP amplitude significantly increased both in patients and controls (PEF). When fatigue set in, MEP amplitude was significantly reduced in normal subjects (PED), but not in patients. Post-exercise MEP findings were similar both in patients with and without fatigue. 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subjects Adult
Biological and medical sciences
Depression
Electric Stimulation
Electrodiagnosis. Electric activity recording
Evoked Potentials, Motor - physiology
Exercise
Facilitation
Fatigue
Female
Fundamental and applied biological sciences. Psychology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic stimulation
Male
Medical sciences
Middle Aged
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Motor Neurons - physiology
Multiple sclerosis
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Muscle Fatigue - physiology
Muscle, Skeletal - innervation
Muscle, Skeletal - physiology
Nervous system
Neurology
Post-exercise facilitation
Transcranial Magnetic Stimulation
Vertebrates: nervous system and sense organs
title Post-exercise facilitation and depression of motor evoked potentials to transcranial magnetic stimulation: a study in multiple sclerosis
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