Post-exercise facilitation and depression of motor evoked potentials to transcranial magnetic stimulation: a study in multiple sclerosis
Objective: To evaluate motor cortex excitability changes by transcranial magnetic stimulation (TMS) following repetitive muscle contractions in patients with multiple sclerosis (MS); to state whether a typical pattern of post-exercise motor evoked potentials (MEPs) is related to clinical fatigue in...
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Veröffentlicht in: | Clinical neurophysiology 2004-09, Vol.115 (9), p.2128-2133 |
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creator | Perretti, A Balbi, P Orefice, G Trojano, L Marcantonio, L Brescia-Morra, V Ascione, S Manganelli, F Conte, G Santoro, L |
description | Objective: To evaluate motor cortex excitability changes by transcranial magnetic stimulation (TMS) following repetitive muscle contractions in patients with multiple sclerosis (MS); to state whether a typical pattern of post-exercise motor evoked potentials (MEPs) is related to clinical fatigue in MS.
Methods: In 41 patients with definite MS (32 with fatigue and 9 without fatigue according to Fatigue Severity Scale) and 13 controls, MEPs were recorded at rest: at baseline condition, following repetitive contractions until fatigue, and after fatigue, to evaluate post-exercise MEP facilitation (PEF) and depression (PED).
Results: After exercise, MEP amplitude significantly increased both in patients and controls (PEF). When fatigue set in, MEP amplitude was significantly reduced in normal subjects (PED), but not in patients. Post-exercise MEP findings were similar both in patients with and without fatigue.
Conclusions: Our findings suggest an intracortical motor dysfunction following a voluntary contraction in MS patients, possibly due to failure of depression of facilitatory cortical circuits, or alternatively of inhibitory mechanisms. |
doi_str_mv | 10.1016/j.clinph.2004.03.028 |
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Methods: In 41 patients with definite MS (32 with fatigue and 9 without fatigue according to Fatigue Severity Scale) and 13 controls, MEPs were recorded at rest: at baseline condition, following repetitive contractions until fatigue, and after fatigue, to evaluate post-exercise MEP facilitation (PEF) and depression (PED).
Results: After exercise, MEP amplitude significantly increased both in patients and controls (PEF). When fatigue set in, MEP amplitude was significantly reduced in normal subjects (PED), but not in patients. Post-exercise MEP findings were similar both in patients with and without fatigue.
Conclusions: Our findings suggest an intracortical motor dysfunction following a voluntary contraction in MS patients, possibly due to failure of depression of facilitatory cortical circuits, or alternatively of inhibitory mechanisms.</description><identifier>ISSN: 1388-2457</identifier><identifier>EISSN: 1872-8952</identifier><identifier>DOI: 10.1016/j.clinph.2004.03.028</identifier><identifier>PMID: 15294215</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Biological and medical sciences ; Depression ; Electric Stimulation ; Electrodiagnosis. Electric activity recording ; Evoked Potentials, Motor - physiology ; Exercise ; Facilitation ; Fatigue ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic stimulation ; Male ; Medical sciences ; Middle Aged ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Motor Neurons - physiology ; Multiple sclerosis ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Multiple Sclerosis, Relapsing-Remitting - physiopathology ; Muscle Fatigue - physiology ; Muscle, Skeletal - innervation ; Muscle, Skeletal - physiology ; Nervous system ; Neurology ; Post-exercise facilitation ; Transcranial Magnetic Stimulation ; Vertebrates: nervous system and sense organs</subject><ispartof>Clinical neurophysiology, 2004-09, Vol.115 (9), p.2128-2133</ispartof><rights>2004 International Federation of Clinical Neurophysiology</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-2ec1d3608fae7a90352fc1b9ac9f4e9d3a4145454d0721b472f95e3def33a6f13</citedby><cites>FETCH-LOGICAL-c388t-2ec1d3608fae7a90352fc1b9ac9f4e9d3a4145454d0721b472f95e3def33a6f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinph.2004.03.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16031062$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15294215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perretti, A</creatorcontrib><creatorcontrib>Balbi, P</creatorcontrib><creatorcontrib>Orefice, G</creatorcontrib><creatorcontrib>Trojano, L</creatorcontrib><creatorcontrib>Marcantonio, L</creatorcontrib><creatorcontrib>Brescia-Morra, V</creatorcontrib><creatorcontrib>Ascione, S</creatorcontrib><creatorcontrib>Manganelli, F</creatorcontrib><creatorcontrib>Conte, G</creatorcontrib><creatorcontrib>Santoro, L</creatorcontrib><title>Post-exercise facilitation and depression of motor evoked potentials to transcranial magnetic stimulation: a study in multiple sclerosis</title><title>Clinical neurophysiology</title><addtitle>Clin Neurophysiol</addtitle><description>Objective: To evaluate motor cortex excitability changes by transcranial magnetic stimulation (TMS) following repetitive muscle contractions in patients with multiple sclerosis (MS); to state whether a typical pattern of post-exercise motor evoked potentials (MEPs) is related to clinical fatigue in MS.
Methods: In 41 patients with definite MS (32 with fatigue and 9 without fatigue according to Fatigue Severity Scale) and 13 controls, MEPs were recorded at rest: at baseline condition, following repetitive contractions until fatigue, and after fatigue, to evaluate post-exercise MEP facilitation (PEF) and depression (PED).
Results: After exercise, MEP amplitude significantly increased both in patients and controls (PEF). When fatigue set in, MEP amplitude was significantly reduced in normal subjects (PED), but not in patients. Post-exercise MEP findings were similar both in patients with and without fatigue.
Conclusions: Our findings suggest an intracortical motor dysfunction following a voluntary contraction in MS patients, possibly due to failure of depression of facilitatory cortical circuits, or alternatively of inhibitory mechanisms.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Depression</subject><subject>Electric Stimulation</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Evoked Potentials, Motor - physiology</subject><subject>Exercise</subject><subject>Facilitation</subject><subject>Fatigue</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic stimulation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Motor Neurons - physiology</subject><subject>Multiple sclerosis</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Multiple Sclerosis, Relapsing-Remitting - physiopathology</subject><subject>Muscle Fatigue - physiology</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - physiology</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Post-exercise facilitation</subject><subject>Transcranial Magnetic Stimulation</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>1388-2457</issn><issn>1872-8952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcuKFDEUDaI4Y-sfiGSjuyrzqKcLYRh8wYAudB3SyY2mTSVlbmpw_sDPNm03zE4Cyb2Xcw8n5xDynLOWMz68PrQm-Lj-aAVjXctky8T0gFzyaRTNNPfiYa3lNDWi68cL8gTxwBgbWScekwvei7kTvL8kf74kLA38hmw8AnXa-OCLLj5FqqOlFtYMiMc2ObqkkjKF2_QTLF1TgVi8DkhLoiXriKZedUAX_T1C8YZi8csW_tG9obq2m72jPtI6LH4NQNEEyAk9PiWPXKWCZ-d3R769f_f1-mNz8_nDp-urm8bUz5RGgOFWDmxyGkY9M9kLZ_h-1mZ2HcxW6o53fT2WjYLvu1G4uQdpwUmpB8fljrw68a45_doAi1o8GghBR0gbqmEYh2kQsgK7E9BUfZjBqTX7Rec7xZk6JqAO6pSAOiagmFQ1gbr24sy_7Rew90tnyyvg5Rmg0ejgqmXV-nvcwCRnVcCOvD3hoLpx6yErNB6iAeszmKJs8v9X8hfeWKoU</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Perretti, A</creator><creator>Balbi, P</creator><creator>Orefice, G</creator><creator>Trojano, L</creator><creator>Marcantonio, L</creator><creator>Brescia-Morra, V</creator><creator>Ascione, S</creator><creator>Manganelli, F</creator><creator>Conte, G</creator><creator>Santoro, L</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Post-exercise facilitation and depression of motor evoked potentials to transcranial magnetic stimulation: a study in multiple sclerosis</title><author>Perretti, A ; Balbi, P ; Orefice, G ; Trojano, L ; Marcantonio, L ; Brescia-Morra, V ; Ascione, S ; Manganelli, F ; Conte, G ; Santoro, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-2ec1d3608fae7a90352fc1b9ac9f4e9d3a4145454d0721b472f95e3def33a6f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Depression</topic><topic>Electric Stimulation</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Evoked Potentials, Motor - physiology</topic><topic>Exercise</topic><topic>Facilitation</topic><topic>Fatigue</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic stimulation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Motor Neurons - physiology</topic><topic>Multiple sclerosis</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Multiple Sclerosis, Relapsing-Remitting - physiopathology</topic><topic>Muscle Fatigue - physiology</topic><topic>Muscle, Skeletal - innervation</topic><topic>Muscle, Skeletal - physiology</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Post-exercise facilitation</topic><topic>Transcranial Magnetic Stimulation</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perretti, A</creatorcontrib><creatorcontrib>Balbi, P</creatorcontrib><creatorcontrib>Orefice, G</creatorcontrib><creatorcontrib>Trojano, L</creatorcontrib><creatorcontrib>Marcantonio, L</creatorcontrib><creatorcontrib>Brescia-Morra, V</creatorcontrib><creatorcontrib>Ascione, S</creatorcontrib><creatorcontrib>Manganelli, F</creatorcontrib><creatorcontrib>Conte, G</creatorcontrib><creatorcontrib>Santoro, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perretti, A</au><au>Balbi, P</au><au>Orefice, G</au><au>Trojano, L</au><au>Marcantonio, L</au><au>Brescia-Morra, V</au><au>Ascione, S</au><au>Manganelli, F</au><au>Conte, G</au><au>Santoro, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-exercise facilitation and depression of motor evoked potentials to transcranial magnetic stimulation: a study in multiple sclerosis</atitle><jtitle>Clinical neurophysiology</jtitle><addtitle>Clin Neurophysiol</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>115</volume><issue>9</issue><spage>2128</spage><epage>2133</epage><pages>2128-2133</pages><issn>1388-2457</issn><eissn>1872-8952</eissn><abstract>Objective: To evaluate motor cortex excitability changes by transcranial magnetic stimulation (TMS) following repetitive muscle contractions in patients with multiple sclerosis (MS); to state whether a typical pattern of post-exercise motor evoked potentials (MEPs) is related to clinical fatigue in MS.
Methods: In 41 patients with definite MS (32 with fatigue and 9 without fatigue according to Fatigue Severity Scale) and 13 controls, MEPs were recorded at rest: at baseline condition, following repetitive contractions until fatigue, and after fatigue, to evaluate post-exercise MEP facilitation (PEF) and depression (PED).
Results: After exercise, MEP amplitude significantly increased both in patients and controls (PEF). When fatigue set in, MEP amplitude was significantly reduced in normal subjects (PED), but not in patients. Post-exercise MEP findings were similar both in patients with and without fatigue.
Conclusions: Our findings suggest an intracortical motor dysfunction following a voluntary contraction in MS patients, possibly due to failure of depression of facilitatory cortical circuits, or alternatively of inhibitory mechanisms.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15294215</pmid><doi>10.1016/j.clinph.2004.03.028</doi><tpages>6</tpages></addata></record> |
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subjects | Adult Biological and medical sciences Depression Electric Stimulation Electrodiagnosis. Electric activity recording Evoked Potentials, Motor - physiology Exercise Facilitation Fatigue Female Fundamental and applied biological sciences. Psychology Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic stimulation Male Medical sciences Middle Aged Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Motor Neurons - physiology Multiple sclerosis Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Multiple Sclerosis, Relapsing-Remitting - physiopathology Muscle Fatigue - physiology Muscle, Skeletal - innervation Muscle, Skeletal - physiology Nervous system Neurology Post-exercise facilitation Transcranial Magnetic Stimulation Vertebrates: nervous system and sense organs |
title | Post-exercise facilitation and depression of motor evoked potentials to transcranial magnetic stimulation: a study in multiple sclerosis |
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