Comparison of posterolateral lumbar fusion rates of Grafton putty and OP-1 putty in an athymic rat model
Posterolateral lumbar spine fusions in athymic rats. To compare spine fusion rates of two different osteoinductive products. Many osteoinductive bone graft alternatives are available. Grafton (a demineralized bone matrix [DBM]) and Osteogenic Protein-1 (OP-1, an individual recombinant bone morphogen...
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| Veröffentlicht in: | Spine (Philadelphia, Pa. 1976) Pa. 1976), 2004-08, Vol.29 (15), p.1612-1617 |
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| container_title | Spine (Philadelphia, Pa. 1976) |
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| creator | BOMBACK, David A GRAUER, Jonathan N LUGO, Roberto TROIANO, Nancy PATEL, Tushar Ch FRIEDLAENDER, Gary E |
| description | Posterolateral lumbar spine fusions in athymic rats.
To compare spine fusion rates of two different osteoinductive products.
Many osteoinductive bone graft alternatives are available. Grafton (a demineralized bone matrix [DBM]) and Osteogenic Protein-1 (OP-1, an individual recombinant bone morphogenetic protein) are two such alternatives. The relative efficacy of products from these two classes has not been previously studied. The athymic rat spine fusion model has been validated and demonstrated useful to minimize inflammatory responses to xenogeneic or differentially expressed proteins such as those presented by DBMs of human etiology.
Single-level intertransverse process fusions were performed in 60 athymic nude rats with 2 cc/kg of Grafton or OP-1 Putty. Half of each study group was killed at 3 weeks and half at 6 weeks. Fusion masses were assessed by radiography, manual palpation, and histology.
At 3 weeks, manual palpation revealed a 13% fusion rate with Grafton and a 100% fusion rate with OP-1 (P = 0.0001). At 6 weeks, manual palpation revealed a 39% fusion rate of with Grafton and a 100% fusion rate with OP-1 (P = 0.0007). Similar fusion rates were found by histology at 3 and 6 weeks. Of note, one or two adjacent levels were fused in all of the OP-1 animals and none of the Grafton animals.
Significant differences between the ability of Grafton and OP-1 to induce bone formation in an athymic rat posterolateral lumbar spine fusion model were found. |
| doi_str_mv | 10.1097/01.BRS.0000132512.53305.A1 |
| format | Article |
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To compare spine fusion rates of two different osteoinductive products.
Many osteoinductive bone graft alternatives are available. Grafton (a demineralized bone matrix [DBM]) and Osteogenic Protein-1 (OP-1, an individual recombinant bone morphogenetic protein) are two such alternatives. The relative efficacy of products from these two classes has not been previously studied. The athymic rat spine fusion model has been validated and demonstrated useful to minimize inflammatory responses to xenogeneic or differentially expressed proteins such as those presented by DBMs of human etiology.
Single-level intertransverse process fusions were performed in 60 athymic nude rats with 2 cc/kg of Grafton or OP-1 Putty. Half of each study group was killed at 3 weeks and half at 6 weeks. Fusion masses were assessed by radiography, manual palpation, and histology.
At 3 weeks, manual palpation revealed a 13% fusion rate with Grafton and a 100% fusion rate with OP-1 (P = 0.0001). At 6 weeks, manual palpation revealed a 39% fusion rate of with Grafton and a 100% fusion rate with OP-1 (P = 0.0007). Similar fusion rates were found by histology at 3 and 6 weeks. Of note, one or two adjacent levels were fused in all of the OP-1 animals and none of the Grafton animals.
Significant differences between the ability of Grafton and OP-1 to induce bone formation in an athymic rat posterolateral lumbar spine fusion model were found.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/01.BRS.0000132512.53305.A1</identifier><identifier>PMID: 15284503</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott</publisher><subject>Activin Receptors, Type I ; Animals ; Biological and medical sciences ; Bone Morphogenetic Protein 7 ; Bone Morphogenetic Proteins ; Cerebrospinal fluid. Meninges. Spinal cord ; Glycerol - pharmacology ; Humans ; Lumbar Vertebrae - anatomy & histology ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - surgery ; Medical sciences ; Models, Animal ; Nervous system (semeiology, syndromes) ; Neurology ; Osteogenesis - drug effects ; Proteins - pharmacology ; Radiography ; Rats ; Rats, Nude ; Spinal Fusion</subject><ispartof>Spine (Philadelphia, Pa. 1976), 2004-08, Vol.29 (15), p.1612-1617</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-2c9db4184d3ef6953f09cae271305e7847d5d43be9c95e7986617a6781a106173</citedby><cites>FETCH-LOGICAL-c374t-2c9db4184d3ef6953f09cae271305e7847d5d43be9c95e7986617a6781a106173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16016571$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15284503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOMBACK, David A</creatorcontrib><creatorcontrib>GRAUER, Jonathan N</creatorcontrib><creatorcontrib>LUGO, Roberto</creatorcontrib><creatorcontrib>TROIANO, Nancy</creatorcontrib><creatorcontrib>PATEL, Tushar Ch</creatorcontrib><creatorcontrib>FRIEDLAENDER, Gary E</creatorcontrib><title>Comparison of posterolateral lumbar fusion rates of Grafton putty and OP-1 putty in an athymic rat model</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>Posterolateral lumbar spine fusions in athymic rats.
To compare spine fusion rates of two different osteoinductive products.
Many osteoinductive bone graft alternatives are available. Grafton (a demineralized bone matrix [DBM]) and Osteogenic Protein-1 (OP-1, an individual recombinant bone morphogenetic protein) are two such alternatives. The relative efficacy of products from these two classes has not been previously studied. The athymic rat spine fusion model has been validated and demonstrated useful to minimize inflammatory responses to xenogeneic or differentially expressed proteins such as those presented by DBMs of human etiology.
Single-level intertransverse process fusions were performed in 60 athymic nude rats with 2 cc/kg of Grafton or OP-1 Putty. Half of each study group was killed at 3 weeks and half at 6 weeks. Fusion masses were assessed by radiography, manual palpation, and histology.
At 3 weeks, manual palpation revealed a 13% fusion rate with Grafton and a 100% fusion rate with OP-1 (P = 0.0001). At 6 weeks, manual palpation revealed a 39% fusion rate of with Grafton and a 100% fusion rate with OP-1 (P = 0.0007). Similar fusion rates were found by histology at 3 and 6 weeks. Of note, one or two adjacent levels were fused in all of the OP-1 animals and none of the Grafton animals.
Significant differences between the ability of Grafton and OP-1 to induce bone formation in an athymic rat posterolateral lumbar spine fusion model were found.</description><subject>Activin Receptors, Type I</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone Morphogenetic Protein 7</subject><subject>Bone Morphogenetic Proteins</subject><subject>Cerebrospinal fluid. Meninges. Spinal cord</subject><subject>Glycerol - pharmacology</subject><subject>Humans</subject><subject>Lumbar Vertebrae - anatomy & histology</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - surgery</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Osteogenesis - drug effects</subject><subject>Proteins - pharmacology</subject><subject>Radiography</subject><subject>Rats</subject><subject>Rats, Nude</subject><subject>Spinal Fusion</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF9PwyAUxYnRuDn9CqYx0bdWbim0-DYXnSZLZvzzTBiFrKYtFdqHfXupNhkPcO_hdyD3IHQDOAHM83sMyeP7R4LDApJSSBNKCKbJEk7QHGhaxACUn6I5JiyN04ywGbrw_jvwjAA_R7MRyigmc7Rf2aaTrvK2jayJOut77Wwtwy7rqB6anXSRGXwV7l1Q_UitnTR9ELqh7w-RbMto-xbD1FZtUCLZ7w9NpUZP1NhS15fozMja66vpXKCv56fP1Uu82a5fV8tNrEie9XGqeLnLoMhKog3jlBjMldRpDmFCnRdZXtIyIzvNFQ89LxiDXLK8AAk4lGSB7v7f7Zz9GbTvRVN5petattoOXjCWs4xTGsCHf1A5673TRnSuaqQ7CMBizFlgECFnccxZ_OUslhDM19Mvw67R5dE6BRuA2wmQXsnaONmqyh85hoHRMNQvW5OGEQ</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>BOMBACK, David A</creator><creator>GRAUER, Jonathan N</creator><creator>LUGO, Roberto</creator><creator>TROIANO, Nancy</creator><creator>PATEL, Tushar Ch</creator><creator>FRIEDLAENDER, Gary E</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040801</creationdate><title>Comparison of posterolateral lumbar fusion rates of Grafton putty and OP-1 putty in an athymic rat model</title><author>BOMBACK, David A ; GRAUER, Jonathan N ; LUGO, Roberto ; TROIANO, Nancy ; PATEL, Tushar Ch ; FRIEDLAENDER, Gary E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-2c9db4184d3ef6953f09cae271305e7847d5d43be9c95e7986617a6781a106173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Activin Receptors, Type I</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone Morphogenetic Protein 7</topic><topic>Bone Morphogenetic Proteins</topic><topic>Cerebrospinal fluid. Meninges. Spinal cord</topic><topic>Glycerol - pharmacology</topic><topic>Humans</topic><topic>Lumbar Vertebrae - anatomy & histology</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - surgery</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Osteogenesis - drug effects</topic><topic>Proteins - pharmacology</topic><topic>Radiography</topic><topic>Rats</topic><topic>Rats, Nude</topic><topic>Spinal Fusion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOMBACK, David A</creatorcontrib><creatorcontrib>GRAUER, Jonathan N</creatorcontrib><creatorcontrib>LUGO, Roberto</creatorcontrib><creatorcontrib>TROIANO, Nancy</creatorcontrib><creatorcontrib>PATEL, Tushar Ch</creatorcontrib><creatorcontrib>FRIEDLAENDER, Gary E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOMBACK, David A</au><au>GRAUER, Jonathan N</au><au>LUGO, Roberto</au><au>TROIANO, Nancy</au><au>PATEL, Tushar Ch</au><au>FRIEDLAENDER, Gary E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of posterolateral lumbar fusion rates of Grafton putty and OP-1 putty in an athymic rat model</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>29</volume><issue>15</issue><spage>1612</spage><epage>1617</epage><pages>1612-1617</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>Posterolateral lumbar spine fusions in athymic rats.
To compare spine fusion rates of two different osteoinductive products.
Many osteoinductive bone graft alternatives are available. Grafton (a demineralized bone matrix [DBM]) and Osteogenic Protein-1 (OP-1, an individual recombinant bone morphogenetic protein) are two such alternatives. The relative efficacy of products from these two classes has not been previously studied. The athymic rat spine fusion model has been validated and demonstrated useful to minimize inflammatory responses to xenogeneic or differentially expressed proteins such as those presented by DBMs of human etiology.
Single-level intertransverse process fusions were performed in 60 athymic nude rats with 2 cc/kg of Grafton or OP-1 Putty. Half of each study group was killed at 3 weeks and half at 6 weeks. Fusion masses were assessed by radiography, manual palpation, and histology.
At 3 weeks, manual palpation revealed a 13% fusion rate with Grafton and a 100% fusion rate with OP-1 (P = 0.0001). At 6 weeks, manual palpation revealed a 39% fusion rate of with Grafton and a 100% fusion rate with OP-1 (P = 0.0007). Similar fusion rates were found by histology at 3 and 6 weeks. Of note, one or two adjacent levels were fused in all of the OP-1 animals and none of the Grafton animals.
Significant differences between the ability of Grafton and OP-1 to induce bone formation in an athymic rat posterolateral lumbar spine fusion model were found.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>15284503</pmid><doi>10.1097/01.BRS.0000132512.53305.A1</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0362-2436 |
| ispartof | Spine (Philadelphia, Pa. 1976), 2004-08, Vol.29 (15), p.1612-1617 |
| issn | 0362-2436 1528-1159 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Activin Receptors, Type I Animals Biological and medical sciences Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins Cerebrospinal fluid. Meninges. Spinal cord Glycerol - pharmacology Humans Lumbar Vertebrae - anatomy & histology Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - surgery Medical sciences Models, Animal Nervous system (semeiology, syndromes) Neurology Osteogenesis - drug effects Proteins - pharmacology Radiography Rats Rats, Nude Spinal Fusion |
| title | Comparison of posterolateral lumbar fusion rates of Grafton putty and OP-1 putty in an athymic rat model |
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