Impaired osteoblastogenesis in myeloma bone disease: role of upregulated apoptosis by cytokines and malignant plasma cells

Summary Bone remodelling is severely affected in myeloma bone disease as a consequence of skeletal metastatization of malignant plasma cells. We investigated whether defective bone replacement is dependent on increased osteoblast apoptosis and/or on deregulated events within the bone microenvironmen...

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Veröffentlicht in:	British journal of haematology 2004-08, Vol.126 (4), p.475-486
Hauptverfasser:	Silvestris, Franco, Cafforio, Paola, Calvani, Nicola, Dammacco, Franco
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Apoptosis Biological and medical sciences Cell Adhesion Chemokine CCL2 - metabolism Coculture Techniques cytokines Cytokines - blood Cytokines - physiology Hematologic and hematopoietic diseases Hematology Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Intercellular Adhesion Molecule-1 - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocyte Function-Associated Antigen-1 - physiology Medical sciences Middle Aged Multiple Myeloma - complications Multiple Myeloma - pathology myeloma bone disease osteoblasts Osteoblasts - metabolism Osteoblasts - pathology Osteolysis - etiology Osteolysis - pathology plasma cells Plasma Cells - pathology Tumor Cells, Cultured Up-Regulation
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