Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo: Intracellular mechanisms

Background We assessed the influence of sequential treatment of ionizing radiation followed by tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) on intracellular mechanisms of apoptosis of prostate tumor cells in vitro and in vivo. Methods Prostate normal and cancer cells were ex...

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Veröffentlicht in:	The Prostate 2004-09, Vol.61 (1), p.35-49
Hauptverfasser:	Shankar, Sharmila, Singh, Thiyam Ramsing, Srivastava, Rakesh K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - drug effects Apoptosis - radiation effects Apoptosis Regulatory Proteins Arabidopsis Proteins - metabolism Bak Bax Bcl-2 bcl-2 Homologous Antagonist-Killer Protein Caspases - metabolism Cell Line, Tumor Combined Modality Therapy death receptors Fatty Acid Desaturases - metabolism Genes, bcl-2 irradiation Male Membrane Glycoproteins - pharmacology Membrane Proteins - metabolism Methyl Ethers - metabolism Mice Mice, Inbred BALB C Mice, Nude p53 prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms - radiotherapy Proto-Oncogene Proteins c-bcl-2 - metabolism Random Allocation Receptors, TNF-Related Apoptosis-Inducing Ligand Receptors, Tumor Necrosis Factor - metabolism TNF-Related Apoptosis-Inducing Ligand TRAIL Tumor Necrosis Factor-alpha - pharmacology Tumor Suppressor Protein p53 - metabolism
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