Interactions between angiotensin II and NF-kappaB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy

NF-kappaB-dependent pathways play an important role in macrophage infiltration and kidney injury. NF-kappaB is regulated by angiotensin II (AII). However, the role of this pathway in diabetic nephropathy has not been clearly delineated. First, the activation of NF-kappaB, monocyte chemoattractant pr...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2004-08, Vol.15 (8), p.2139-2151
Hauptverfasser:	Lee, Fiona T H, Cao, Zemin, Long, David M, Panagiotopoulos, Sianna, Jerums, George, Cooper, Mark E, Forbes, Josephine M
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Angiotensin II Type 1 Receptor Blockers Angiotensin II Type 2 Receptor Blockers Animals Antioxidants - pharmacology Biomarkers Chemokine CCL2 - genetics Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Electrophoretic Mobility Shift Assay Gene Expression I-kappa B Proteins - metabolism Macrophages - pathology Male NF-kappa B - metabolism NF-kappa B p50 Subunit NF-KappaB Inhibitor alpha Pyrrolidines - pharmacology Rats Rats, Sprague-Dawley Receptor, Angiotensin, Type 1 - metabolism Receptor, Angiotensin, Type 2 - metabolism Thiocarbamates - pharmacology Transcription Factor RelA
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