Target-biased scoring approaches and expert systems in structure-based virtual screening

Structure-based virtual screening followed by selection of a top fraction of the rank-ordered result list suffers from many false positives and false negatives because the general scoring functions are not accurate enough. Many approaches have emerged to address this problem by including knowledge a...

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Veröffentlicht in:Current opinion in chemical biology 2004-08, Vol.8 (4), p.359-364
Hauptverfasser: Jansen, Johanna M, Martin, Eric J
Format: Artikel
Sprache:eng
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