A general statistical principle for changing a design any time during the course of a trial

A general method is presented that allows the researcher to change statistical design elements such as the residual sample size during the course of an experiment, to include an interim analysis for early stopping when no formal rule for early stopping was foreseen, to increase or reduce the number...

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Veröffentlicht in:	Statistics in medicine 2004-08, Vol.23 (16), p.2497-2508
Hauptverfasser:	Muller, Hans-Helge, Schafer, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptive designs Antiparkinson Agents - therapeutic use Clinical trials conditional rejection probability design modifications Electric Stimulation Therapy group sequential clinical trials Humans interim analyses Medical research Models, Statistical Parkinson Disease - therapy Probability Quality of Life Randomized Controlled Trials as Topic - methods Research Design Sample Size sample size reassessment Statistical analysis Subthalamic Nucleus - surgery type I error
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